{"id":8382,"date":"2022-03-24T14:39:59","date_gmt":"2022-03-24T05:39:59","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8382"},"modified":"2022-03-24T15:27:37","modified_gmt":"2022-03-24T06:27:37","slug":"%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d%e3%82%a4%e3%83%b3%e3%83%88%e5%88%86%e5%ad%90pd-l1%e3%81%ae%e8%84%b1%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%82%92%e6%8a%91%e3%81%88","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d%e3%82%a4%e3%83%b3%e3%83%88%e5%88%86%e5%ad%90pd-l1%e3%81%ae%e8%84%b1%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%82%92%e6%8a%91%e3%81%88\/","title":{"rendered":"\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u5206\u5b50PD-L1\u306e\u8131\u7cd6\u9396\u4fee\u98fe\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u4e0a\u54bd\u982d\u764c\u306b\u5bfe\u3059\u308bT-\u7d30\u80de\u514d\u75ab\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b"},"content":{"rendered":"<p>Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001TGF-\u03b21\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u4e0a\u54bd\u982d\u764c\u306b\u304a\u3051\u308bPD-1\/PD-L1\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u306e\u963b\u5bb3\u3092\u5897\u5f37\u3059\u308b\u3068\u3044\u3046\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63d0\u6848\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35311117\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35311117\/<\/a><\/p>\n<p>PD-L1\uff08programmed death ligand-1\uff09\u306f\u3001\u816b\u760d\u7d30\u80de\u306b\u767a\u73fe\u3059\u308b\u819c\u8cab\u901a\u578b\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001PD-L1\u306fT-\u7d30\u80de\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u3001T-\u7d30\u80de\u4e0a\u306e\u53d7\u5bb9\u4f53PD-1\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u514d\u75ab\u56de\u907f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>TGF-\u03b2\u306f\u591a\u6a5f\u80fd\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308a\u3001\u764c\u3092\u542b\u3080\u751f\u7406\u5b66\u7684\u304a\u3088\u3073\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306e\u4e21\u65b9\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002 TGF-\u03b2\u306e\u7570\u5e38\u7523\u751f\u306f\u3001\u816b\u760d\u306e\u9032\u884c\u3001\u8840\u7ba1\u65b0\u751f\u3001\u8ee2\u79fb\u3001\u304a\u3088\u3073\u514d\u75ab\u56de\u907f\u306b\u5f37\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002TGF-\u03b2\u306f\u3001CD8<sup>+<\/sup> T-\u7d30\u80de\u3001NK\u7d30\u80de\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u306e\u6297\u816b\u760d\u6d3b\u6027\u3092\u6291\u5236\u3059\u308b\u91cd\u8981\u306a\u514d\u75ab\u6291\u5236\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/sup><\/p>\n<p>\u3053\u306e\u7814\u7a76\u3067\u306f\u3001PD-L1\u304c\u4e0a\u54bd\u982d\u764c\u3067\u5f37\u304f\u7cd6\u9396\u4fee\u98fe\u3092\u53d7\u3051\u3066\u304a\u308a\u3001TGF-\u03b21\u304cPD-L1\u306eN-\u578b\u7cd6\u9396\u4fee\u98fe\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002TGF-\u03b2 Type I\u578b\u53d7\u5bb9\u4f53\u963b\u5bb3\u5264\uff08SB431542\uff09\u306b\u3088\u308bTGF-\u03b21\u306e\u963b\u5bb3\u306f\u3001PD-L1\u81ea\u4f53\u306e\u767a\u73fe\u4f4e\u4e0b\u3060\u3051\u3067\u306a\u304f\u3001PD-L1\u306eN-\u578b\u7cd6\u9396\u4fee\u98fe\u306e\u6e1b\u5c11\u3082\u62db\u304d\u307e\u3057\u305f\u3002 PD-L1\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u6e1b\u5c11\u306f\u3001\u30ec\u30af\u30c1\u30f3ConA\u306ePD-L1\u7d50\u5408\u80fd\u306e\u55aa\u5931\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u8457\u8005\u3089\u306f\u3001PD-L1\u306eN-\u578b\u7cd6\u9396\u4fee\u98fe\u304cc-Jun\/STT3A\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u4ecb\u3057\u3066TGF-\u03b21\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u3001TGF-\u03b21\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001PD-L1\u306e\u8131\u7cd6\u9396\u4fee\u98fe\u3092\u6291\u5236\u3057\u306a\u304c\u3089\u3001\u4e0a\u54bd\u982d\u764c\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u304c\u6709\u671b\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u306a\u308a\u5f97\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8383\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1-300x264.png\" alt=\"\" width=\"300\" height=\"264\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1-300x264.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1-600x528.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1.png 629w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a> \u4e0a\u54bd\u982d\u764c\u7d30\u80de\uff085-8F\u7d30\u80de\uff09\u3068 Jurkat T-\u7d30\u80de\u306e\u5171\u57f9\u990a\u3001STT3A-knockdown\u7d30\u80de\uff08shSTT3A\u7d30\u80de\uff09\u3001T-\u7d30\u80de\u306eSB431542 \u3068 tunicamycin (TM) \u524d\u51e6\u7406\u3092\u7d61\u307e\u305b\u3066<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e5%85%8d%e7%96%ab%e3%83%81%e3%82%a7%e3%83%83%e3%82%af%e3%83%9d%e3%82%a4%e3%83%b3%e3%83%88%e5%88%86%e5%ad%90pd-l1%e3%81%ae%e8%84%b1%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%82%92%e6%8a%91%e3%81%88\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-8382","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8382"}],"version-history":[{"count":12,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8382\/revisions"}],"predecessor-version":[{"id":8395,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8382\/revisions\/8395"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}