{"id":8345,"date":"2022-03-22T10:22:53","date_gmt":"2022-03-22T01:22:53","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8345"},"modified":"2022-03-22T10:24:41","modified_gmt":"2022-03-22T01:24:41","slug":"changes-in-gastric-mucosal-glycosylation-before-and-after-helicobacter-pylori-eradication-studies-using-lectin-microarray","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/changes-in-gastric-mucosal-glycosylation-before-and-after-helicobacter-pylori-eradication-studies-using-lectin-microarray\/","title":{"rendered":"Changes in gastric mucosal glycosylation before and after Helicobacter pylori Eradication: Studies using Lectin Microarray"},"content":{"rendered":"

A group from Department of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan, has reported about changes in gastric mucosal glycosylation before and after Helicobacter pylori Eradication.
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/35238778\/<\/a><\/p>\n

It was found that the jacalin and MPA signals in the gastric antrum were significantly lower in the H. pylori infection group than in the gastric mucosa of the group without H. pylori infection, and that, 1 year after eradication, the signals returned to the levels seen without infection.
\nThe LTL, SNA, SSA, and TJA-I signals in the gastric body were significantly increased in the H. pylori infection group and returned to the levels seen without infection 1 year after eradication. <\/p>\n

\"\"<\/a><\/p>\n

MPA and jacalin are 85% homologous, and these lectins have particularly high specificity for the TF-antigen that is expressed in more than 85% of human carcinomas.
\nLTL binds to Lewisx<\/sup>, Lewisy<\/sup> and H-antigen type II, and has been reported to be a marker for cancer progression in bladder cancer cell lines.
\nSNA has been reported to be a marker for the diagnosis, metastasis, and prognosis of colorectal and pancreatic cancers and hepatocellular carcinoma. SNA has also been reported to be a diagnostic marker for pneumonia and a predictive marker for diabetic nephropathy progression. SNA, SSA, and TJA-I have the same glycan binding specificity, \u03b12-6Sia. <\/p>\n

The results of this study showed that the signal levels for lectin binding to glycans resulting from H. pylori infection returned to the levels seen without infection as a result of H. pylori eradication. Thus, the data are intriguing in that they indicate that glycosylation is reversible.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Department of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan, has reported a<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-8345","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t