{"id":8251,"date":"2022-03-11T12:52:38","date_gmt":"2022-03-11T03:52:38","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8251"},"modified":"2022-03-11T12:54:18","modified_gmt":"2022-03-11T03:54:18","slug":"an-ace2-fc-fusion-protein-could-be-a-good-therapeutic-drug-overcoming-viral-escape-of-sars-cov-2-variants","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/an-ace2-fc-fusion-protein-could-be-a-good-therapeutic-drug-overcoming-viral-escape-of-sars-cov-2-variants\/","title":{"rendered":"An ACE2-Fc fusion protein could be a good therapeutic drug overcoming viral escape of SARS-CoV-2 variants"},"content":{"rendered":"<p>A group from SystImmune Inc., 15318 NE 95th St., Redmond, WA, 98052, USA, etc. has reported that ACE2-Fc fusion protein could be a good therapeutic drug overcoming viral escape of SARS-CoV-2 variants.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8882475\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8882475\/<\/a><\/p>\n<p>Interestingly, the pseudovirus neutralization data using the ACE2-Fc fusion protein named SI-F09 (shown below) shows that the higher the binding strength between SARS-CoV-2 RBD and ACE2, the lower the IC<sub>50<\/sub> values. In other words, the IC<sub>50<\/sub> value for WT is the highest among SARS-CoV-2 variants imcruding Omicron. <\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/ACE2-Fc-fusion-protein_SARS-CoV-2-variants.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/ACE2-Fc-fusion-protein_SARS-CoV-2-variants-300x206.png\" alt=\"\" width=\"300\" height=\"206\" class=\"alignnone size-medium wp-image-8245\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/ACE2-Fc-fusion-protein_SARS-CoV-2-variants-300x206.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/ACE2-Fc-fusion-protein_SARS-CoV-2-variants-600x413.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/ACE2-Fc-fusion-protein_SARS-CoV-2-variants-1024x705.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/ACE2-Fc-fusion-protein_SARS-CoV-2-variants-768x528.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/ACE2-Fc-fusion-protein_SARS-CoV-2-variants.png 1042w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>In the meantime, a phase I clinical trial evaluating safety of SI\u2013F019 in healthy patients has been conducted (ClinicalTrials.gov Identifier: NCT04851444) and is being analyzed in preparation for future clinical studies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from SystImmune Inc., 15318 NE 95th St., Redmond, WA, 98052, USA, etc. has reported that ACE2-Fc fusio<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/an-ace2-fc-fusion-protein-could-be-a-good-therapeutic-drug-overcoming-viral-escape-of-sars-cov-2-variants\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-8251","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8251"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8251\/revisions"}],"predecessor-version":[{"id":8252,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8251\/revisions\/8252"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}