{"id":8226,"date":"2022-03-11T10:02:27","date_gmt":"2022-03-11T01:02:27","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8226"},"modified":"2022-03-11T10:02:27","modified_gmt":"2022-03-11T01:02:27","slug":"%e9%aa%a8%e9%ab%84%e6%80%a7%e7%b4%b0%e8%83%9e%e3%81%ab%e7%99%ba%e7%8f%be%e3%81%99%e3%82%8bc-type-lectin-receptor-5a-clec5a-%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%a8%e6%a9%9f%e8%83%bd%e3%81%ab%e3%81%a4","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e9%aa%a8%e9%ab%84%e6%80%a7%e7%b4%b0%e8%83%9e%e3%81%ab%e7%99%ba%e7%8f%be%e3%81%99%e3%82%8bc-type-lectin-receptor-5a-clec5a-%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%a8%e6%a9%9f%e8%83%bd%e3%81%ab%e3%81%a4\/","title":{"rendered":"\u9aa8\u9ac4\u6027\u7d30\u80de\u306b\u767a\u73fe\u3059\u308bC-Type lectin receptor 5A (CLEC5A) \u306e\u767a\u73fe\u3068\u6a5f\u80fd\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>Cancer Immunology &amp; Immune Modulation, Boehringer Ingelheim Pharma GmbH &amp; Co. KG, Germany\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u9aa8\u9ac4\u6027\u7d30\u80de\u306b\u767a\u73fe\u3059\u308bC-Type lectin receptor 5A (CLEC5A) \u306e\u767a\u73fe\u3068\u6a5f\u80fd\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8896916\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8896916\/<\/a><\/p>\n<p>\u9aa8\u9ac4\u6027DAP12\u95a2\u9023\u30ec\u30af\u30c1\u30f3-1\uff08MDL-1\uff09\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u308bCLEC5A\u306f\u3001\u75c5\u539f\u4f53\u306e\u8868\u9762\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308b\u7cd6\u9396\u306b\u512a\u5148\u7684\u306b\u7d50\u5408\u3059\u308b\u9aa8\u9ac4\u6027Syk\u7d50\u5408\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\u3067\u3059\u3002 CLEC5A\u306f\u4e3b\u306b\u9aa8\u9ac4\u7d30\u80de\uff08\u5358\u7403\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u597d\u4e2d\u7403\u3001\u6a39\u72b6\u7d30\u80de\uff09\u3067\u767a\u73fe\u3057\u3001IFN-\u03b3\u306b\u3088\u3063\u3066\u3055\u3089\u306b\u767a\u73fe\u304c\u6602\u9032\u3055\u308c\u307e\u3059\u3002 CLEC5A\u304c\u7d50\u5408\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u306f\u3001\u30c7\u30f3\u30b0\u71b1\u30a6\u30a4\u30eb\u30b9\u3001\u65e5\u672c\u8133\u708e\u30a6\u30a4\u30eb\u30b9\u3001\u305d\u3057\u3066\u307e\u305fA\u578b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306b\u767a\u73fe\u3059\u308b\u7cd6\u9396\u306e\u672b\u7aef\u30d5\u30b3\u30fc\u30b9\u304a\u3088\u3073\u30de\u30f3\u30ce\u30fc\u30b9\u69cb\u9020\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u66f4\u306b\u3001CLEC5A\u306f\u3001\u7d30\u83cc\u306e\u7d30\u80de\u58c1\uff08\u30ea\u30b9\u30c6\u30ea\u30a2\u30fb\u30e2\u30ce\u30b5\u30a4\u30c8\u30b2\u30cd\u30b9\u3084\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306a\u3069\uff09\u306e\u4e8c\u7cd6\u985e\uff08N-\u30a2\u30bb\u30c1\u30eb\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u304a\u3088\u3073N-\u30a2\u30bb\u30c1\u30eb\u30e0\u30e9\u30df\u30f3\u9178\uff09\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3082\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u6a5f\u80fd\u7684\u306b\u306f\u3001\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\u307e\u305f\u306f\u4ed6\u306e\u75c5\u539f\u4f53\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308bCLEC5A\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u306f\u3001\u708e\u75c7\u8a98\u767a\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08TNF-\u03b1\u3001IL-1\u3001IL-6\u3001IL-8\u3001\u304a\u3088\u3073IL-17A\uff09\u304a\u3088\u3073\u30b1\u30e2\u30ab\u30a4\u30f3\uff08\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u708e\u75c7\u6027\u30bf\u30f3\u30d1\u30af\u8cea-1\u03b1\uff09\u3001IFN-\u03b3\u8a98\u5c0e\u30bf\u30f3\u30d1\u30af\u8cea\uff08IP-10\/CXCL10\uff09\u3001\u304a\u3088\u3073\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u7531\u6765\u30b1\u30e2\u30ab\u30a4\u30f3\uff08CCL22\/MDC\uff09\u306e\u7523\u751f\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002 CLEC5A\u306f\u3001\u75c5\u539f\u4f53\u95a2\u9023\u6297\u539f\u3060\u3051\u3067\u306a\u304f\u3001\u3044\u304f\u3064\u304b\u306e\u5185\u56e0\u6027\u5371\u967a\u4fe1\u53f7\u3082\u8a8d\u8b58\u3057\u3001\u305d\u306e\u7d50\u679c\u3001\u7121\u83cc\u6027\u708e\u75c7\u306e\u75c5\u56e0\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3082\u5224\u660e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u30ec\u30dd\u30fc\u30c8\u3067\u306f\u3001\u5358\u7403\u7531\u6765\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3067\u306eCLEAC5A\u306e\u767a\u73fe\u72b6\u614b\u3068\u3001\u03b1-CLEC5A Ab\u306b\u3088\u308bCLEC5A\u306e\u9078\u629e\u7684\u6d3b\u6027\u5316\u306b\u3088\u308b\u6a5f\u80fd\u767a\u73fe\u3001\u304a\u3088\u3073\u81ea\u5df1T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3078\u306e\u5f71\u97ff\u304c\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u9aa8\u9ac4\u6027\u7d30\u80de\u3067\u306eCLEC5A\u306e\u767a\u73fe\u72b6\u614b<\/strong><br \/>\nCLEAC5A\u306e\u767a\u73fe\u72b6\u614b\u3092\u5e7e\u3064\u304b\u306e\u5358\u7403\u7531\u6765\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08MdM\uff09\u9593\u3067\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3059\u3002\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8 M1\u3001\u4e2d\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8 M0\u3001\u816b\u760d\u5f62\u6210\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8 M2c\u3001\u304a\u3088\u3073in vitro\u816b\u760d\u95a2\u9023\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08TAM\uff09\u3067\u3059\u3002 CLEC5A\u306e\u767a\u73fe\u306f\u3001\u5358\u7403\u304a\u3088\u3073\u4ed6\u306eMdM\u30b5\u30d6\u30bb\u30c3\u30c8\uff08M0\u304a\u3088\u3073M2c\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001M1 MdM\u3067\u6709\u610f\u306b\u4e0a\u6607\u3057\u307e\u3057\u305f\u304c\u3001TAM\u3078\u306e\u5358\u7403\u306e\u5206\u5316\u306fCLEC5A\u306e\u767a\u73fe\u306e\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><strong>CLEC5A\u6d3b\u6027\u5316\u306b\u3088\u308b\u6a5f\u80fd\u767a\u73fe<\/strong><br \/>\n\u975e\u611f\u67d3\u6027\u6761\u4ef6\u4e0b\u3067\u306eCLEC5A\u30a2\u30b4\u30cb\u30b9\u30c8\u306e\u6a5f\u80fd\u7684\u52b9\u679c\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001M0 MdM\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5fdc\u7b54\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002 \u03b1-CLEC5A Ab\u306b\u523a\u6fc0\u3055\u308c\u305fM0 MdM\u306b\u304a\u3044\u3066\u3001TNF-\u03b1\u3001IL-6\u3001IL-10\u3001IL-1b\u3001CCL22\/MDC\u3001CCL17\/TARC\u3001\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08MMP1\uff09\u306a\u3069\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304a\u3088\u3073\u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u7523\u751f\u304c\u6709\u610f\u306b\u6602\u9032\u3055\u308c\u307e\u3057\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001CLEC5A\u306e\u6d3b\u6027\u5316\u306f\u3001CD80\u3001PD-L1\u3001CD206\uff08MRC-1\uff09\u3001CD209\uff08DC-SIGN\uff09\u306a\u3069\u306e\u9aa8\u9ac4\u7d30\u80de\u7279\u7570\u7684\u8868\u9762\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u6602\u9032\u3092\u3082\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u6700\u5f8c\u306b\u3001\u7121\u83cc\u72b6\u614b\u3067\u306e\u9aa8\u9ac4\u7d30\u80de\u306e\u9078\u629e\u7684CLEC5A\u3092\u4ecb\u3057\u305f\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306f\u3001\u81ea\u5bb6T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u306b\u306f\u4e0d\u5341\u5206\u3067\u3042\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cancer Immunology &amp; Immune Modulation, Boehringer Ingelheim Pharma GmbH &amp; Co. KG, Germany\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u9aa8\u9ac4\u6027\u7d30\u80de<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e9%aa%a8%e9%ab%84%e6%80%a7%e7%b4%b0%e8%83%9e%e3%81%ab%e7%99%ba%e7%8f%be%e3%81%99%e3%82%8bc-type-lectin-receptor-5a-clec5a-%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%a8%e6%a9%9f%e8%83%bd%e3%81%ab%e3%81%a4\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-8226","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8226"}],"version-history":[{"count":15,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8226\/revisions"}],"predecessor-version":[{"id":8241,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8226\/revisions\/8241"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}