{"id":8194,"date":"2022-03-09T08:44:34","date_gmt":"2022-03-08T23:44:34","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8194"},"modified":"2022-03-10T07:10:25","modified_gmt":"2022-03-09T22:10:25","slug":"%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e7%b4%b0%e8%83%9e%e6%af%92%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e7%b4%b0%e8%83%9e%e6%af%92%e6%80%a7\/","title":{"rendered":"\u30ec\u30af\u30c1\u30f3\u306e\u7d30\u80de\u6bd2\u6027"},"content":{"rendered":"<p>Institute of Physiology, University of Zurich, Zurich, Switzerland\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30ec\u30af\u30c1\u30f3\u306e\u7d30\u80de\u6bd2\u6027\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8866831\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8866831\/<\/a><\/p>\n<p>\u30ec\u30af\u30c1\u30f3\u306b\u3088\u308b\u7d30\u80de\u8868\u9762\u7cd6\u9396\u306e\u6a19\u7684\u5316\u306f\u764c\u6cbb\u7642\u306e\u6709\u671b\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u304c\u3001\u30ec\u30af\u30c1\u30f3\u30d9\u30fc\u30b9\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\uff08\u30ec\u30af\u30c1\u30f3\u5358\u72ec\u307e\u305f\u306f\u4ed6\u306e\u6cbb\u7642\u85ac\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\uff09\u306f\u307e\u3060\u958b\u767a\u306e\u521d\u671f\u6bb5\u968e\u306b\u3042\u308a\u307e\u3059\u3002\u7cd6\u9396\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u306b\u57fa\u3065\u304f\u52b9\u7387\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u306f\u3001\u6a19\u7684\u816b\u760d\u7d30\u80de\u4e0a\u306e\u30ec\u30af\u30c1\u30f3\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u7d30\u80de\u6b7b\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6df1\u304f\u7406\u89e3\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u5b9a\u306e\u30ec\u30af\u30c1\u30f3\u304c\u7570\u306a\u308b\u30bf\u30a4\u30d7\u306e\u816b\u760d\u7d30\u80de\u3067\u7570\u306a\u308b\u30e2\u30fc\u30c9\u306e\u7d30\u80de\u6b7b\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u5c0f\u9ea6\u80da\u82bd\u30ec\u30af\u30c1\u30f3\uff08WGA\uff09\u306f\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u3068\u767d\u8840\u75c5\u7d30\u80de\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u3001\u30d1\u30e9\u30c8\u30fc\u30b7\u30b9\u306e\u3088\u3046\u306a\u7d30\u80de\u6b7b\u306b\u3088\u3063\u3066\u9838\u90e8\u764c\u7d30\u80de\u3092\u6bba\u3059\u3053\u3068\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001\u30de\u30a6\u30b9\u817a\u764c\u7d30\u80de\uff08MC-38\uff09\u3068\u82e5\u3044\u6210\u4f53\u30de\u30a6\u30b9\u7d50\u8178\u7d30\u80de\uff08YAMC\uff09\u3092\u4f7f\u7528\u3057\u3066\u3001\u30ec\u30af\u30c1\u30f3\uff08MAL I\u3001MAL II\u3001SNA\u3001AAL\u3001WGA\u3001\u304a\u3088\u3073ECL\uff09\u51e6\u7406\u306b\u3088\u3063\u3066\u8a98\u8d77\u3055\u308c\u308b\u69d8\u3005\u306a\u7d30\u80de\u6b7b\u7d4c\u8def\uff08\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3001\u30d1\u30e9\u30c8\u30fc\u30b7\u30b9\u3001\u304a\u3088\u3073\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u4f9d\u5b58\u6027\u7d30\u80de\u6b7b\uff09\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u30ec\u30af\u30c1\u30f3\u306e\u7d30\u80de\u6bd2\u6027\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u7d30\u80de\u6b7b\u3092\u5a92\u4ecb\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u5224\u5225\u3059\u308b\u305f\u3081\u306b\u3001\u7d30\u80de\u6b7b\u5fdc\u7b54\u306b\u95a2\u4e0e\u3059\u308b\u69d8\u3005\u306a\u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3057\u305fMC-38\u7d30\u80de\u306e\u30d1\u30cd\u30eb\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3055\u308c\u305f\u907a\u4f1d\u5b50\u306f\u6b21\u306e\u901a\u308a\u3067\u3059\uff1a<br \/>\n\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u4fc3\u9032\u30bf\u30f3\u30d1\u30af\u8ceaBCL2\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\/\u30ad\u30e9\u30fc1\uff08<strong>BAK1<\/strong>\uff09\u304a\u3088\u3073BCL2\u95a2\u9023X\uff08<strong>BAX<\/strong>\uff09\u306f\u3001<strong>\u5185\u56e0\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9<\/strong>\u3092\u5a92\u4ecb\u3057\u307e\u3059\u3001\u5185\u56e0\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306f\u3001DNA\u640d\u50b7\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u5185\u90e8\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u56e0\u5b50\u306b\u5fdc\u7b54\u3057\u3066\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>Fas\u7d50\u5408\u30c7\u30b9\u30c9\u30e1\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\uff08<strong>FADD<\/strong>\uff09\u306f\u3001<strong>\u5916\u56e0\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9<\/strong>\u3092\u5a92\u4ecb\u3057\u307e\u3059\u3001\u5916\u56e0\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306f\u3001\u7d30\u80de\u6b7b\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u306b\u5fdc\u7b54\u3057\u3066\u8a98\u5c0e\u3055\u308c\u3001\u305d\u306e\u5f8c\u3001 FADD\u3068\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc-8\u3092\u542b\u3080\u7d30\u80de\u6b7b\u8a98\u5c0e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-3\u3092\u5207\u65ad\u3057\u307e\u3059\u3002<\/p>\n<p>\u816b\u760d\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u56e0\u5b50\u53d7\u5bb9\u4f531\u578b\u7d50\u5408\u30c7\u30b9\u30c9\u30e1\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\uff08<strong>TRADD<\/strong>\uff09\u3001\u53d7\u5bb9\u4f53\u76f8\u4e92\u4f5c\u7528\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc3\uff08<strong>RIPK3<\/strong>\uff09\u3001\u6df7\u5408\u7cfb\u7d71\u30ad\u30ca\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea\uff08<strong>MLKL<\/strong>\uff09\u304a\u3088\u3073\u30ab\u30b9\u30d1\u30fc\u30bc-8\uff08<strong>CASP8<\/strong>\uff09\u306f\u3001<strong>\u30ab\u30b9\u30d1\u30fc\u30bc\u975e\u4f9d\u5b58\u6027\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9<\/strong>\u3092\u5a92\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<p>\u30ab\u30b9\u30d1\u30fc\u30bc-1\uff08<strong>CASP1<\/strong>\uff09\u3068\u30ac\u30b9\u30c7\u30eb\u30df\u30f3D\uff08<strong>GSDMD<\/strong>\uff09\u306f\u3001<strong>\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9<\/strong>\u3092\u5a92\u4ecb\u3057\u307e\u3059\u3001CASP1\u306f\u3001\u69d8\u3005\u306a\u5fae\u751f\u7269\u611f\u67d3\u3084\u975e\u611f\u67d3\u6027\u306e\u523a\u6fc0\u306b\u5fdc\u7b54\u3057\u3066\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u306fGSDMD\u5207\u65ad\u306b\u3064\u306a\u304c\u308a\u3001\u3053\u308c\u304c\u539f\u5f62\u8cea\u819c\u306b\u57cb\u3081\u8fbc\u307e\u308c\u3066\u7d30\u5b54\u304c\u3067\u304d\u308b\u3053\u3068\u3067\u3001\u30a4\u30aa\u30f3\u52fe\u914d\u3092\u4e71\u3057\u3066\u6c34\u306e\u6d41\u5165\u3092\u4fc3\u9032\u3057\u3001\u7d30\u80de\u306e\u816b\u308c\u3068\u6d78\u900f\u5727\u6eb6\u89e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n<p><strong>\u7d50\u679c\uff1a<\/strong><br \/>\nBAX\/BAK1\u8907\u5408\u4f53\u306e\u4e0d\u6d3b\u6027\u5316\u306f\u3001WGA\u3001MAL I\u3001\u304a\u3088\u3073AAL\u51e6\u7406\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u7d30\u80de\u6bd2\u6027\u53cd\u5fdc\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3057\u305f\u3002\u7d30\u80de\u6bd2\u6027\u306e50\uff05\u4ee5\u4e0a\u306e\u6e1b\u5c11\u306f\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u53e4\u5178\u7684\u306a\u30c8\u30ea\u30ac\u30fc\u3067\u3042\u308b\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3067\u51e6\u7406\u3055\u308c\u305f\u7d30\u80de\u3067\u307f\u3089\u308c\u308b\u52b9\u679c\u3068\u540c\u69d8\u3067\u3057\u305f\u3002\u5bfe\u7167\u7684\u306b\u3001FADD\u306e\u4e0d\u6d3b\u6027\u5316\u306f\u3001WGA\u3001MAL I\u3001\u304a\u3088\u3073AAL\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u7d30\u80de\u6b7b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u53d7\u5bb9\u4f531\uff08TNFR1\uff09\u306e\u4e0b\u6d41\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u306a\u5225\u306e\u30a2\u30c0\u30d7\u30bf\u30fc\u5206\u5b50\u3067\u3042\u308bTRADD\u306e\u4e0d\u6d3b\u6027\u5316\u306f\u3001MAL I\u3067\u51e6\u7406\u3057\u305f\u7d30\u80de\u306e\u7d30\u80de\u6b7b\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3057\u305f\u304c\u3001WGA\u3068AAL\u306e\u5834\u5408\u306b\u306f\u6e1b\u5c11\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002 MLKL\u306e\u4f4e\u4e0b\u304c\u3001WGA\u3001MAL I\u3001\u304a\u3088\u3073AAL\u306e\u7d30\u80de\u6bd2\u6027\u52b9\u679c\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304b\u3089\u3001\u3053\u308c\u3089\u30ec\u30af\u30c1\u30f3\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u7d30\u80de\u6b7b\u306b\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u304c\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>CASP1\u307e\u305f\u306fGSDMD\u306e\u3044\u305a\u308c\u304b\u306e\u4e0d\u6d3b\u5316\u306f\u3001MAL I\u3092\u4ecb\u3057\u305f\u7d30\u80de\u6bd2\u6027\u306e\u308f\u305a\u304b\u306a\u6e1b\u5c11\u306e\u307f\u3092\u793a\u3057\u3001MAL I\u51e6\u7406\u306b\u5fdc\u7b54\u3057\u305f\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u90e8\u5206\u7684\u306a\u95a2\u4e0e\u3092\u88cf\u4ed8\u3051\u3066\u3044\u307e\u3059\u3002 CASP1\u306e\u4e0d\u6d3b\u5316\u306f\u3001MAL\u304a\u3088\u3073AAL\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u7d30\u80de\u6bd2\u6027\u306e\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u8a98\u5c0e\u306b\u52a0\u3048\u3066\u3001\u591a\u304f\u306e\u30ec\u30af\u30c1\u30f3\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u6602\u9032\u3055\u305b\u3001<strong>\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u4f9d\u5b58\u6027\u306e\u7d30\u80de\u6b7b<\/strong>\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002 LC3-II\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b4\u30bd\u30fc\u30e0\u819c\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u304c\u3001\u30ec\u30af\u30c1\u30f3\u30676\u6642\u9593\u51e6\u7406\u3057\u305f\u7d30\u80de\u304b\u3089\u306e\u6eb6\u89e3\u7269\u306b\u304a\u3044\u3066\u3001MAL I\u3001AAL\u3001\u304a\u3088\u3073WGA\u51e6\u7406\u3067LC3-II\u306e\u767a\u73fe\u304c\u6602\u9032\u3057\u3066\u3044\u307e\u3057\u305f\u3002 LC3-II\u306e\u5897\u52a0\u306f\u3001MAL I\u3001AAL\u3001\u304a\u3088\u3073WGA\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u7d30\u80de\u6b7b\u304c\u3001\u53e4\u5178\u7684\u306a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7d4c\u8def\u3067\u306f\u306a\u304f\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\/\u30ea\u30bd\u30bd\u30fc\u30e0\u5fdc\u7b54\u306e\u6d3b\u6027\u5316\u306b\u3088\u3063\u3066\u958b\u59cb\u3055\u308c\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u3001\u98e2\u9913\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u30b7\u30af\u30ed\u30d8\u30ad\u30b7\u30df\u30c9\uff08CHX\uff09\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30013\u3064\u306e\u30ec\u30af\u30c1\u30f3\u306e\u7d30\u80de\u6bd2\u6027\u53cd\u5fdc\u304c\u5927\u5e45\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/lectin-cytotoxicity.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8210\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/lectin-cytotoxicity-245x300.png\" alt=\"\" width=\"245\" height=\"300\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/lectin-cytotoxicity-245x300.png 245w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/lectin-cytotoxicity.png 394w\" sizes=\"auto, (max-width: 245px) 100vw, 245px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Institute of Physiology, University of Zurich, Zurich, Switzerland\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30ec\u30af\u30c1\u30f3\u306e\u7d30\u80de\u6bd2\u6027\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.ncb<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e7%b4%b0%e8%83%9e%e6%af%92%e6%80%a7\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-8194","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8194"}],"version-history":[{"count":27,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8194\/revisions"}],"predecessor-version":[{"id":8225,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8194\/revisions\/8225"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}