{"id":8006,"date":"2022-02-20T13:17:53","date_gmt":"2022-02-20T04:17:53","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8006"},"modified":"2022-02-20T16:57:14","modified_gmt":"2022-02-20T07:57:14","slug":"the-importance-of-glycan-glycan-interactions-in-hiv-infection","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/the-importance-of-glycan-glycan-interactions-in-hiv-infection\/","title":{"rendered":"The importance of glycan-glycan interactions in HIV infection"},"content":{"rendered":"

A group of Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia has reported the importance of glycan-glycan interactions in HIV infection.
\nHost glycocalyx captures HIV proximal to the cell surface via<\/a><\/p>\n

Current understanding of the roles of HIV glycans include: (1) to protect HIV from immune recognition; (2) to stabilize the trimeric envelope structure; and (3) to mediate trans-infection of T lymphocytes via electrostatic glycan-lectin (host proteinaceous lectin) interactions.<\/p>\n

As is well know, all HIV Envelops are heavily glycosylated with variable N-linked glycans distributed across ~30 N-linked glycosylation sites, and many of these sites are primary occupied with oligomannose N-glycans, including Man5-9<\/sub>GlcNAc2<\/sub>-Asn and Man3<\/sub>GlcNAc2<\/sub>-Asn core structures.<\/p>\n

While much is known about HIV entry, the initial interactions between virus and cell prior to HIV envelope-CD4 receptor-dependent interactions is rather unclear.<\/p>\n

In this report, it was shown that glycan-glycan interactions could initiate HIV-cell contacts, that is, HIV- and host cell-glycan interactions via HIV oligomannose, Man5 (Man\u03b11-3Man\u03b11-6[Man\u03b11-3]Man; a representative terminal HIV N-glycan structure, and host cell GlcNAc could potentiate HIV-host cell attachment.<\/p>\n

\"\"<\/a><\/p>\n

So, it can be said that glycan-glycan interactions are emerging as a new class of high-affinity biomolecular interactions in virus infection.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group of Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia has reported the impo<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-8006","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t