{"id":7419,"date":"2022-01-12T20:53:02","date_gmt":"2022-01-12T11:53:02","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=7419"},"modified":"2022-01-12T21:43:55","modified_gmt":"2022-01-12T12:43:55","slug":"a-novel-approach-using-glycoprotein-targeted-chimeric-antigen-receptor-car-nk-cells-for-the-treatment-of-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-novel-approach-using-glycoprotein-targeted-chimeric-antigen-receptor-car-nk-cells-for-the-treatment-of-sars-cov-2-infection\/","title":{"rendered":"A novel approach using glycoprotein targeted chimeric antigen receptor (CAR)-NK Cells for the treatment of SARS-CoV-2 infection"},"content":{"rendered":"<p>A group from The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA, etc. has reported a novel approach using glycoprotein targeted chimeric antigen receptor (CAR)-NK Cells for the treatment of SARS-CoV-2 infection.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8732772\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8732772\/<\/a><\/p>\n<p>NK cells are innate lymphocytes of the immune system with an important role in the control of viral infections, and CAR-T and CAR-NK cells are emerging immunotherapies against cancer and infectious disease with great promise. <\/p>\n<p>Typically, the expressed synthetic receptors on NK cells are designed to bind target surface protein. In this study, authors designed a CAR making use of a unique extracellular moiety (i.e., lectin) with binding properties dependent on target glycosylation. Targeting of glycoprotein, and specifically N-glycosylation products, with a CAR is rare. This is the first CAR targeting the N-glycans dispersed on SARS-CoV-2 Spike protein, and also, this would be the first lectin-based CAR designed and functionally tested in pre-clinical study. <\/p>\n<p>As lectins have evolved over millions of years to be highly potent and selective to glycans, the H84T-BanLec CAR represents an entirely new approach in that it targets aberrant glycosylation patterns (high mannose, in this case) in SARS-CoV-2 viral proteins. Here, Banlec is a lectin which is known to have binding specificity to high mannose which exists in proximity to the receptor binding domain of the envelope SARS-CoV-2 Spike protein.<\/p>\n<p>There is a strong need for the development of CARs with receptor targeting patterns that are less likely to be impacted by genomic point mutations observed in RNA virus such as SARS-CoV-2.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Balti<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-novel-approach-using-glycoprotein-targeted-chimeric-antigen-receptor-car-nk-cells-for-the-treatment-of-sars-cov-2-infection\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-7419","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/7419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=7419"}],"version-history":[{"count":5,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/7419\/revisions"}],"predecessor-version":[{"id":7427,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/7419\/revisions\/7427"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=7419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=7419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=7419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}