{"id":7395,"date":"2022-01-09T09:33:49","date_gmt":"2022-01-09T00:33:49","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=7395"},"modified":"2022-01-09T09:36:14","modified_gmt":"2022-01-09T00:36:14","slug":"sars-cov-2-omicron-showed-higher-infectivity-in-human-nasal-epithelial-cells-but-the-reason-is-not-only-due-to-strong-binding-to-hace2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/sars-cov-2-omicron-showed-higher-infectivity-in-human-nasal-epithelial-cells-but-the-reason-is-not-only-due-to-strong-binding-to-hace2\/","title":{"rendered":"SARS-CoV-2 Omicron showed higher infectivity in human nasal epithelial cells, but the reason is not only due to strong binding to hACE2"},"content":{"rendered":"

A group from Department of Infectious Disease, Imperial College London, UK, etc. has reported about SARS-CoV-2 Omicron’s higher infectivity in human nasal epithelial cells (hNECs) and its possible reasons.
\nhttps:\/\/www.biorxiv.org\/content\/10.1101\/2021.12.31.474653v1<\/a><\/p>\n

SARS-CoV-2 Omicron showed a large early replication advantage in human nasal epithelial cells (hNECs), yielding viral titres \uff5e100-fold higher than Delta by 24 hours post-infection. At 48 and 72 hours post-infection, viral titres were lower compared to Delta and at 72 hours the RNA collected from Omicron infected wells was fewer. In Vero-AT cells, replication of the two variants was equal. In Calu-3 cells, the viral yields of Omicron were lower than for Delta across all time points.<\/p>\n

Previous SARS-CoV-2 variants, such as Delta, only enter cells efficiently by binding ACE2 and activating fusion via cell-surface protease TMPRSS2. Omicron, conversely, is able to enter cells in both a TMPRSS2-dependent and \u2013independent manner, having evolved the ability to avoid endosomal restriction. This allows Omicron to infect any ACE2-expressing cell in the airway instead of relying solely on double ACE+ TMPRSS2+ cells.<\/p>\n

It was also found omicron Spike bound better to mouse ACE2 than any previous variant, as several others have reported. This suggests a possibility that omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host, then jumped back into humans.
\n\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Department of Infectious Disease, Imperial College London, UK, etc. has reported about SARS-CoV-2<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-7395","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t