{"id":7388,"date":"2022-01-09T09:33:49","date_gmt":"2022-01-09T00:33:49","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=7388"},"modified":"2022-01-09T09:33:49","modified_gmt":"2022-01-09T00:33:49","slug":"%e3%82%aa%e3%83%9f%e3%82%af%e3%83%ad%e3%83%b3%e3%81%af%e3%80%81%e9%bc%bb%e8%85%94%e4%b8%8a%e7%9a%ae%e3%81%a7%e3%83%87%e3%83%ab%e3%82%bf%e3%82%88%e3%82%8a%e3%82%82100%e5%80%8d%e5%a2%97%e6%ae%96","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%82%aa%e3%83%9f%e3%82%af%e3%83%ad%e3%83%b3%e3%81%af%e3%80%81%e9%bc%bb%e8%85%94%e4%b8%8a%e7%9a%ae%e3%81%a7%e3%83%87%e3%83%ab%e3%82%bf%e3%82%88%e3%82%8a%e3%82%82100%e5%80%8d%e5%a2%97%e6%ae%96\/","title":{"rendered":"\u30aa\u30df\u30af\u30ed\u30f3\u306f\u3001\u9f3b\u8154\u4e0a\u76ae\u3067\u30c7\u30eb\u30bf\u3088\u308a\u3082100\u500d\u5897\u6b96\u3057\u6613\u3044\u3001\u3057\u304b\u3057\u3001\u305d\u306e\u539f\u56e0\u306fhACE2\u306b\u5bfe\u3059\u308b\u7d50\u5408\u529b\u304c\u4e0a\u304c\u3063\u3066\u3044\u308b\u3053\u3068\u3060\u3051\u3067\u306f\u306a\u3044"},"content":{"rendered":"<p>Department of Infectious Disease, Imperial College London, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2 \u30aa\u30df\u30af\u30ed\u30f3\u306e\u30d2\u30c8\u9f3b\u8154\u4e0a\u76ae\u7d30\u80de\uff08hNEC\uff09\u306b\u304a\u3051\u308b\u3088\u308a\u9ad8\u3044\u611f\u67d3\u529b\u3068\u3001\u305d\u306e\u8003\u3048\u3089\u308c\u308b\u7406\u7531\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.12.31.474653v1\">https:\/\/www.biorxiv.org\/content\/10.1101\/2021.12.31.474653v1<\/a><\/p>\n<p>SARS-CoV-2 \u30aa\u30df\u30af\u30ed\u30f3\u306f\u3001\u30d2\u30c8\u9f3b\u8154\u4e0a\u76ae\u7d30\u80de\u3067\u611f\u67d3\u521d\u671f\u306e\u5897\u5e45\u529b\u304c\u9ad8\u304f\u3001\u611f\u67d3\u5f8c24\u6642\u9593\u307e\u3067\u306b\u30c7\u30eb\u30bf\u3088\u308a\u3082\u7d04100\u500d\u9ad8\u3044\u5897\u6b96\u529b\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u611f\u67d3\u5f8c48\u6642\u9593\u3092\u904e\u304e\u308b\u3068\u3001\u30aa\u30df\u30af\u30ed\u30f3\u306f\u30c7\u30eb\u30bf\u3068\u6bd4\u8f03\u3057\u3066\u4f4e\u4e0b\u3057\u59cb\u3081\u300172\u6642\u9593\u3067\u306f\u3001\u30aa\u30df\u30af\u30ed\u30f3\u306f\u5c11\u306a\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002 Vero-AT\u30bb\u30eb\u3067\u306f\u30012\u3064\u306e\u5909\u7570\u682a\u306e\u5897\u6b96\u7387\u306f\u540c\u7b49\u3067\u3057\u305f\u304c\u3001Calu-3\u7d30\u80de\u3067\u306f\u3001\u30aa\u30df\u30af\u30ed\u30f3\u306f\u3001\u3059\u3079\u3066\u306e\u6642\u70b9\u3067\u30c7\u30eb\u30bf\u3088\u308a\u3082\u4f4e\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u30c7\u30eb\u30bf\u306a\u3069\u306e\u4ee5\u524d\u306eSARS-CoV-2\u5909\u7570\u4f53\u306f\u3001ACE2\u306b\u7d50\u5408\u3057\u3001\u7d30\u80de\u8868\u9762\u30d7\u30ed\u30c6\u30a2\u30fc\u30bcTMPRSS2\u3092\u4ecb\u3057\u3066\u878d\u5408\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u306e\u307f\u52b9\u7387\u7684\u306b\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30aa\u30df\u30af\u30ed\u30f3\u306f\u3001\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u5236\u9650\u3092\u56de\u907f\u3059\u308b\u80fd\u529b\u3092\u9032\u5316\u3055\u305b\u3066\u3001TMPRSS2\u4f9d\u5b58\u304a\u3088\u3073\u975e\u4f9d\u5b58\u306e\u4e21\u65b9\u306e\u65b9\u6cd5\u3067\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30aa\u30df\u30af\u30ed\u30f3\u306f\u3001ACE\u3068TMPRSS2\u304c\u4e21\u65b9\u767a\u73fe\u6602\u9032\u3057\u3066\u3044\u308b\u7d30\u80de\u3060\u3051\u306b\u983c\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u6c17\u9053\u5185\u306eACE2\u767a\u73fe\u7d30\u80de\u306b\u611f\u67d3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u304c\u5897\u6b96\u7387\u30a2\u30c3\u30d7\u306e\u5927\u304d\u306a\u539f\u56e0\u3067\u3042\u308d\u3046\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u4ed6\u306b\u5e7e\u3064\u304b\u306e\u5831\u544a\u4f8b\u3082\u3042\u308a\u307e\u3059\u304c\uff08\u672c\u30d6\u30ed\u30b0\u3067\u30822022\u5e741\u67085\u65e5\u306b\u7d39\u4ecb\uff09\u3001\u30aa\u30df\u30af\u30ed\u30f3\u306eSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u4ee5\u524d\u306e\u3069\u306e\u5909\u7570\u4f53\u3088\u308a\u3082\u30de\u30a6\u30b9\u306eACE2\uff08msACE2\uff09\u306b\u3088\u304f\u7d50\u5408\u3059\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u30aa\u30df\u30af\u30ed\u30f3\u304c\u30d2\u30c8\u304b\u3089\u30de\u30a6\u30b9\u306b\u30b8\u30e3\u30f3\u30d7\u3057\u3001\u305d\u306e\u5bbf\u4e3b\u5185\u3067\u5909\u7570\u3092\u84c4\u7a4d\u3057\u3001\u305d\u3057\u3066\u30d2\u30c8\u306b\u623b\u3063\u3066\u304d\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/omicron_ACE2-binding\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/omicron_ACE2-binding-300x181.png\" alt=\"\" width=\"300\" height=\"181\" class=\"alignnone size-medium wp-image-7389\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/omicron_ACE2-binding-300x181.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/omicron_ACE2-binding.png 589w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Infectious Disease, Imperial College London, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2 \u30aa\u30df\u30af\u30ed\u30f3\u306e\u30d2\u30c8\u9f3b\u8154\u4e0a\u76ae\u7d30\u80de\uff08hNEC\uff09\u306b\u304a\u3051\u308b\u3088\u308a\u9ad8\u3044\u611f\u67d3<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%82%aa%e3%83%9f%e3%82%af%e3%83%ad%e3%83%b3%e3%81%af%e3%80%81%e9%bc%bb%e8%85%94%e4%b8%8a%e7%9a%ae%e3%81%a7%e3%83%87%e3%83%ab%e3%82%bf%e3%82%88%e3%82%8a%e3%82%82100%e5%80%8d%e5%a2%97%e6%ae%96\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-7388","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Department of Infectious Disease, Imperial College Lond\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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