{"id":7334,"date":"2022-01-05T09:25:58","date_gmt":"2022-01-05T00:25:58","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=7334"},"modified":"2022-01-05T11:55:24","modified_gmt":"2022-01-05T02:55:24","slug":"hcov%e3%81%ab%e7%89%b9%e7%95%b0%e7%9a%84%e3%81%aacd8-t%e7%b4%b0%e8%83%9e%e3%81%8c%e3%80%81sars-cov-2%e3%81%ab%e4%ba%a4%e5%b7%ae%e5%8f%8d%e5%bf%9c%e3%82%92%e7%a4%ba%e3%81%99","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/hcov%e3%81%ab%e7%89%b9%e7%95%b0%e7%9a%84%e3%81%aacd8-t%e7%b4%b0%e8%83%9e%e3%81%8c%e3%80%81sars-cov-2%e3%81%ab%e4%ba%a4%e5%b7%ae%e5%8f%8d%e5%bf%9c%e3%82%92%e7%a4%ba%e3%81%99\/","title":{"rendered":"HCoV\u306b\u7279\u7570\u7684\u306aCD8+ T\u7d30\u80de\u304c\u3001SARS-CoV-2\u306b\u4ea4\u5dee\u53cd\u5fdc\u3092\u793a\u3059"},"content":{"rendered":"<p>\u7406\u7814\uff09\u514d\u75ab\u5b66\u7814\u7a76\u6240\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8\u306e\u98a8\u90aa\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u7279\u7570\u7684\u306aCD8<sup>+<\/sup> \u7279\u5b9a\u306eT\u7d30\u80de\u304cSARS-CoV-2\u306b\u5bfe\u3057\u3066\u4ea4\u5dee\u53cd\u5fdc\u3092\u793a\u3059\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8640030\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8640030\/<\/a><\/p>\n<p>\u6700\u8fd1\u3001\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f(HLA)\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u3068COVID-19\u306e\u95a2\u4fc2\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059 <\/p>\n<p>\u8457\u8005\u3089\u306f\u3001\u4e3b\u8981\u306aHLA\u306e1\u3064\u3067\u3042\u308bHLA-A*24\uff1a02\u3068\u3001SARS-CoV-2\u306b\u5bfe\u3057\u3066\u4ea4\u5dee\u53cd\u5fdc\u3059\u308bCD8<sup>+<\/sup> T\u7d30\u80de\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002in vitro\u30a2\u30c3\u30bb\u30a4\u3092\u4f7f\u7528\u3057\u3066\u3001\u764c\u306b\u5bfe\u3059\u308b\u65e2\u5b58\u306eCD8<sup>+<\/sup> T\u7d30\u80de\u3092\u691c\u51fa\u3057\u305f\u308a\u3001SARS-CoV-2\u306b\u5bfe\u3059\u308b\u4ea4\u5dee\u53cd\u5fdc\u6027CD8<sup>+<\/sup> \u3092\u6709\u3059\u308bT\u7d30\u80de\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/HLA-alleles.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/HLA-alleles-300x258.png\" alt=\"\" width=\"300\" height=\"258\" class=\"alignnone size-medium wp-image-7343\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/HLA-alleles-300x258.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/HLA-alleles-600x516.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/HLA-alleles-768x660.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/HLA-alleles.png 964w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a> <em>cited from <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/mhc\/23\/2\/23_115\/_pdf\/-char\/ja\">https:\/\/www.jstage.jst.go.jp\/article\/mhc\/23\/2\/23_115\/_pdf\/-char\/ja<\/a><\/em><\/p>\n<p>PBMC\u3092\u9078\u5225\u3055\u308c\u305f6\u7a2e\u985e\u306e\u30da\u30d7\u30c1\u30c9\uff08Pep#1\uff5ePep#6\uff09\u306e\u5b58\u5728\u4e0b\u3067\u57f9\u990a\u3057\u300121\u65e5\u76ee\u306b\u30a8\u30d4\u30c8\u30fc\u30d7\u7279\u7570\u7684\u306aIFN-\u03b3\u7523\u751fCD8<sup>+<\/sup> T\u7d30\u80de\u306e\u983b\u5ea6\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002SARS-CoV-2 Spike \u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u9078\u629e\u3055\u308c\u305f\u3053\u308c\u30896\u7a2e\u985e\u306e\u30da\u30d7\u30c1\u30c9\u306f<strong> HLA-A*24\uff1a02 <\/strong>\u306b\u9ad8\u3044\u89aa\u548c\u6027\u3067\u7d50\u5408\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u3089\u306e\u3046\u30615\u3064\u306fT\u7d30\u80de\u5fdc\u7b54\u3092\u8a98\u5c0e\u305b\u305a\u3001<strong> Pep#3\uff08\u30a2\u30df\u30ce\u9178\u914d\u5217\uff1d QYIKWPWYI \u3001SARS-CoV-2\u30b9\u30d1\u30a4\u30af\u4f4d\u7f6e\uff1d 1208-1216\uff09-\u7279\u7570\u7684\u306aCD8<sup>+<\/sup> T\u7d30\u80de<\/strong>\u306e\u307f\u304c\u3001\u3059\u3079\u3066\u306eSARS-CoV-2\u306b\u611f\u67d3\u3057\u3066\u3044\u306a\u3044\u5065\u5eb7\u306a\u30c9\u30ca\u30fc\uff08UHD\uff09\u306b\u7531\u6765\u3059\u308b\u7d30\u80de\u3067IFN-\u03b3\u306e\u7523\u751f\u3092\u8a98\u5c0e\u3057\u307e\u3057\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001Pep#3\u306f\u30014\u7a2e\u985e\u306e\u5b63\u7bc0\u6027\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08HCoV\uff09\u3092\u542b\u3080\u4ed6\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3068\u9ad8\u3044\u914d\u5217\u76f8\u540c\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 Spike \u30bf\u30f3\u30d1\u30af\u8cea\u306e6\u7a2e\u985e\u306e\u30da\u30d7\u30c1\u30c9\u3059\u3079\u3066\u304cHLA-A*24\uff1a02\u306b\u5bfe\u3057\u3066\u9ad8\u3044\u89aa\u548c\u6027\u3092\u793a\u3059\u3068\u4e88\u6e2c\u3055\u308c\u307e\u3057\u305f\u304c\u30015\u3064\u306e\u30da\u30d7\u30c1\u30c9\u306f\u4ed6\u306e\u5b63\u7bc0\u6027\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3068\u76f8\u540c\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\n\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001HCoV\u7279\u7570\u7684CD8<sup>+<\/sup> T\u7d30\u80de\u304cSARS-CoV-2\u306b\u5bfe\u3057\u3066\u4ea4\u5dee\u53cd\u5fdc\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u65e2\u5b58\u306e\u30e1\u30e2\u30ea\u30fcCD8<sup>+<\/sup> T\u7d30\u80de\u304c\u514d\u75ab\u5fdc\u7b54\u306e\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u5f37\u304f\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>CD8<sup>+<\/sup> T\u7d30\u80de\u304c\u69d8\u3005\u306a\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u8907\u6570\u306e\u5fdc\u7b54\u3092\u793a\u3059\u7406\u7531\u3068\u305d\u306e\u6839\u5e95\u306b\u3042\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001\u5358\u4e00\u306eTCR\u30ec\u30d9\u30eb\u3067CD8<sup>+<\/sup> T\u7d30\u80de\u306e\u4ea4\u5dee\u53cd\u5fdc\u6027\u3092\u8abf\u3079\u307e\u3057\u305f\u3002 Pep#3\u3067\u518d\u523a\u6fc0\u3057\u305f\u5f8c\u3001CD107a<sup>+<\/sup> CD8\u3092\u30b2\u30fc\u30c6\u30a3\u30f3\u30b0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001Pep#3\u7279\u7570\u7684CD8<sup>+<\/sup> T\u7d30\u80de\u682a\u304b\u3089CD8<sup>+<\/sup> T\u7d30\u80de\u3092\u5358\u96e2\u3057\u3001TCR\u30ec\u30d1\u30fc\u30c8\u30ea\u30fc\u306e\u5358\u4e00\u7d30\u80de\u5206\u6790\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002 Pep#3\u53cd\u5fdc\u6027CD8<sup>+<\/sup> T\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u6027\u3092\u5206\u6790\u3059\u308b\u305f\u3081\u306b\u3001\u5408\u8a08227\u306eT\u7d30\u80de\u304c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u30015\u3064\u306eUHD\u30681\u4eba\u306e\u8840\u6db2\u60aa\u6027\u816b\u760d\uff08HM\uff09\u60a3\u8005\u304b\u308944\u306eTCR\u30af\u30ed\u30fc\u30f3\u30bf\u30a4\u30d7\u304c\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u305d\u306e\u30af\u30ed\u30fc\u30f3\u30bf\u30a4\u30d7\u306e\u4e2d\u304b\u3089\u512a\u52e2\u306aTCR\u30bf\u30a4\u30d7\u306b\u7126\u70b9\u3092\u5f53\u3066\u30014\u3064\u306e\u30c9\u30ca\u30fc\uff083\u3064\u306eUHD\u30681\u3064\u306eHM\uff09\u304b\u30894\u3064\u306e\u30bf\u30a4\u30d7\u306eTCR\u03b1\u3068TCR\u03b2\u306e\u30da\u30a2\u3092\u7279\u5b9a\u3057\u307e\u3057\u305f\u3002\u30af\u30ed\u30fc\u30f3\u5316\u3055\u308c\u305fTCR\u306e\u7279\u7570\u6027\u3068\u6a5f\u80fd\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001TCR\u03b1\u304a\u3088\u3073TCR\u03b2\u907a\u4f1d\u5b50\u3092SKW3-CD8AB\uff08\u30d2\u30c8T-ALL\uff09\u7d30\u80de\u682a\u306b\u5f62\u8cea\u5c0e\u5165\u3057\u3001\u305d\u308c\u3089\u306e\u30da\u30d7\u30c1\u30c9\u7279\u7570\u7684\u5fdc\u7b54\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u30014\u7a2e\u985e\u306eTCR\u30ec\u30d1\u30fc\u30c8\u30ea\u30fc\u306f\u3001\u30a8\u30d4\u30c8\u30fc\u30d7\u8a8d\u8b58\u306b\u304a\u3044\u3066\u4e92\u3044\u306b\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002 UHD2\u306eTCR-T\uff08TCR-T-1\uff09\u7d30\u80de\u306f\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u7531\u6765\u3059\u308b\u3059\u3079\u3066\u306e\u30a8\u30d4\u30c8\u30fc\u30d7\u306b\u3088\u304f\u53cd\u5fdc\u3057\u307e\u3057\u305f\u304c\u3001UHD8\u306eTCR-T\uff08TCR-T-2\uff09\u7d30\u80de\u306fSARS-CoV-1\u3068SARS-CoV-2\u306b\u306e\u307f\u53cd\u5fdc\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/TCR-cross-reactivity_CoVs.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/TCR-cross-reactivity_CoVs-300x98.png\" alt=\"\" width=\"300\" height=\"98\" class=\"alignnone size-medium wp-image-7341\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/TCR-cross-reactivity_CoVs-300x98.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/TCR-cross-reactivity_CoVs-600x195.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/TCR-cross-reactivity_CoVs-768x250.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/01\/TCR-cross-reactivity_CoVs.png 1020w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7406\u7814\uff09\u514d\u75ab\u5b66\u7814\u7a76\u6240\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8\u306e\u98a8\u90aa\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u7279\u7570\u7684\u306aCD8+ \u7279\u5b9a\u306eT\u7d30\u80de\u304cSARS-CoV-2\u306b\u5bfe\u3057\u3066\u4ea4\u5dee\u53cd\u5fdc\u3092\u793a\u3059\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/a<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/hcov%e3%81%ab%e7%89%b9%e7%95%b0%e7%9a%84%e3%81%aacd8-t%e7%b4%b0%e8%83%9e%e3%81%8c%e3%80%81sars-cov-2%e3%81%ab%e4%ba%a4%e5%b7%ae%e5%8f%8d%e5%bf%9c%e3%82%92%e7%a4%ba%e3%81%99\/\" 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