{"id":7263,"date":"2021-12-23T16:49:37","date_gmt":"2021-12-23T07:49:37","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=7263"},"modified":"2021-12-23T16:49:37","modified_gmt":"2021-12-23T07:49:37","slug":"heparin-can-inhibit-sars-cov-2-infection-by-three-mechanisms","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/heparin-can-inhibit-sars-cov-2-infection-by-three-mechanisms\/","title":{"rendered":"Heparin can inhibit SARS-CoV-2 infection by three mechanisms"},"content":{"rendered":"<p>A group from Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS), 69118 Heidelberg, Germany, etc. has reported about three roles of heparin in inhibiting SARS-CoV-2 infection with using molecular dynamics simulations.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34929169\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34929169\/<\/a><\/p>\n<p>Heparin can inhibit SARS-CoV-2 infection by three mechanisms:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7241\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/12\/heparin_SARS-CoV-2.png\" alt=\"\" width=\"542\" height=\"306\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/12\/heparin_SARS-CoV-2.png 542w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/12\/heparin_SARS-CoV-2-300x169.png 300w\" sizes=\"auto, (max-width: 542px) 100vw, 542px\" \/><br \/>\n(1) Heparin binds the S1\/S2-heparin binding domain (HBD) of spike in both the conformations, preventing furin cleavage,<br \/>\n(2) hinders the opening\/activation of the closed spike, and<br \/>\n(3) acts allosterically on the hinge region associated with the movement of the RBD, while directly masking the RBD-HBD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS), 69118<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/heparin-can-inhibit-sars-cov-2-infection-by-three-mechanisms\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-7263","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/7263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=7263"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/7263\/revisions"}],"predecessor-version":[{"id":7264,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/7263\/revisions\/7264"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=7263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=7263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=7263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}