{"id":6987,"date":"2021-12-04T09:50:12","date_gmt":"2021-12-04T00:50:12","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6987"},"modified":"2021-12-04T15:22:00","modified_gmt":"2021-12-04T06:22:00","slug":"%e8%84%82%e8%b3%aa%e3%83%8a%e3%83%8e%e7%b2%92%e5%ad%90%ef%bc%88lnp%ef%bc%89%e3%81%ae%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a2%e3%82%b8%e3%83%a5%e3%83%90","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e8%84%82%e8%b3%aa%e3%83%8a%e3%83%8e%e7%b2%92%e5%ad%90%ef%bc%88lnp%ef%bc%89%e3%81%ae%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a2%e3%82%b8%e3%83%a5%e3%83%90\/","title":{"rendered":"\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff08LNP\uff09\u306emRNA\u30ef\u30af\u30c1\u30f3\u306b\u304a\u3051\u308b\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u3068\u3057\u3066\u306e\u6709\u52b9\u6027"},"content":{"rendered":"

Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA \u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff08LNP\uff09\u304c\u3001\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u3068\u3057\u3066\u30ef\u30af\u30c1\u30f3\u306e\u6709\u52b9\u6027\u3092\u9ad8\u3081\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u30d8\u30de\u30b0\u30eb\u30c1\u30cb\u30f3\u3068\u3001SARS-CoV-2\u306eRNA\u3092\u7528\u3044\u3066\u793a\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8566475\/<\/a><\/p>\n

\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306b\u5bfe\u3059\u308b\u9069\u5fdc\u514d\u75ab\u5fdc\u7b54\u306e\u8cea\u3068\u5927\u304d\u3055\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002 LNP\u30ab\u30d7\u30bb\u30eb\u5316\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98femRNA\u30ef\u30af\u30c1\u30f3\u306f\u3001SARS-CoV-2\u306e\u91cd\u75c7\u6025\u6027\u547c\u5438\u5668\u75c7\u5019\u7fa4\u306b\u5bfe\u3057\u3066\u512a\u308c\u305f\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u30ef\u30af\u30c1\u30f3\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u3053\u306eLNP\u304c\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u6d3b\u6027\u3092\u6301\u3064\u3053\u3068\u3092\u5b9f\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u7a7a\u306eLNP\uff08eLNP\uff09\u304a\u3088\u3073AddaVax\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u30ef\u30af\u30c1\u30f3\u3092\u7528\u3044\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u3092eLNP\u307e\u305f\u306fAddaVax\u3067\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u6dfb\u52a0\u3055\u308c\u305f\u7d44\u63db\u3048SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\uff08rRBD\uff09\u306e\u5358\u56de\u6295\u4e0e\u3067\u514d\u75ab\u3057\u3001\u967d\u6027\u5bfe\u7167\u3068\u3057\u3066\u3001\u3082\u3046\u3072\u3068\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u3092\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4fee\u98feRBD mRNA-LNP\u3067\u514d\u75ab\u3057\u307e\u3057\u305f\u3002\u7d50\u679c\u3001LNP\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u30ef\u30af\u30c1\u30f3\u306f\u3001AddaVax\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u305f\u5fdc\u7b54\u3088\u308a\u3082\u6709\u610f\u306b\u9ad8\u3044RBD\u7279\u7570\u7684IgG\u529b\u4fa1\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u30a4\u30aa\u30f3\u5316\u53ef\u80fd\u306a\u8102\u8cea\u304c\u3042\u308b\u5834\u5408\u3068\u306a\u3044\u5834\u5408\u306eLNP\u306e\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u7279\u6027\u3092\u6bd4\u8f03\u3059\u308b\u305f\u3081\u306b\u30012\u3064\u306e\u7570\u306a\u308b\u7d44\u6210\u3092\u6301\u3064eLNP\u3068\u6df7\u5408\u3057\u305f\u7d44\u307f\u63db\u3048\u30d8\u30de\u30b0\u30eb\u30c1\u30cb\u30f3\uff08rHA\uff09\u3067\u30de\u30a6\u30b9\u3092\u514d\u75ab\u3057\u307e\u3057\u305f\u3002\u30a4\u30aa\u30f3\u5316\u53ef\u80fd\u306a\u8102\u8cea\u3092\u542b\u3080eLNP\u306f\u3001\u9ad8\u3044\u8840\u7403\u51dd\u96c6\u7d20\u963b\u5bb3\u529b\u4fa1\u3092\u793a\u3057\u307e\u3057\u304c\u3001\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001\u30a4\u30aa\u30f3\u5316\u53ef\u80fd\u306a\u8102\u8cea\u3092\u542b\u307e\u306a\u3044eLNP\u306f\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u6d3b\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

IL-6\u306f\u3001T\u6ffe\u80de\u30d8\u30eb\u30d1\u30fc\u7d30\u80de\uff08Tfh\uff09\u5206\u5316\u306e\u521d\u671f\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002Tfh\u7d30\u80de\u306f\u3001\u80da\u4e2d\u5fc3\uff08GC\uff09\u306b\u304a\u3051\u308bB\u7d30\u80de\u306e\u89aa\u548c\u6027\u6210\u719f\u306e\u8abf\u7bc0\u306b\u7279\u5316\u3057\u305fCD4+<\/sup> T\u7d30\u80de\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u3067\u3042\u308a\u3001Tfh\u7d30\u80de\u306e\u8a98\u5c0e\u306f\u3001\u6301\u7d9a\u6027\u306e\u3042\u308b\u514d\u75ab\u5fdc\u7b54\u306b\u3068\u3063\u3066\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002\u30a4\u30aa\u30f3\u5316\u53ef\u80fd\u306a\u8102\u8cea\u3092\u542b\u3080eLNP\u3068mRNA-LNP\u306f\u3001\u5927\u91cf\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-6\u306a\u3069\uff09\u3068\u30b1\u30e2\u30ab\u30a4\u30f3\u3092\u8a98\u767a\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001\u30a4\u30aa\u30f3\u5316\u53ef\u80fd\u306a\u8102\u8cea\u3092\u6b20\u304fLNP\u3068AddaVax\u3067\u306f\u3001\u4f4e\u3044\u30ec\u30d9\u30eb\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u8a98\u5c0e\u306b\u7559\u307e\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a> where, empty LNP (eLNP), AddaVax (an MF59-like adjuvant).<\/p>\n","protected":false},"excerpt":{"rendered":"

Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA \u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff08LNP\uff09\u304c\u3001\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u3068\u3057\u3066\u30ef\u30af\u30c1\u30f3\u306e\u6709<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-6987","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6987","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6987"}],"version-history":[{"count":28,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6987\/revisions"}],"predecessor-version":[{"id":7021,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6987\/revisions\/7021"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6987"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6987"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6987"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}