{"id":6954,"date":"2021-12-01T10:24:32","date_gmt":"2021-12-01T01:24:32","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6954"},"modified":"2021-12-01T15:59:25","modified_gmt":"2021-12-01T06:59:25","slug":"sars-cov-2%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%aa%81%e7%84%b6%e5%a4%89%e7%95%b0%e3%81%ae%e4%bd%8d%e7%bd%ae%e3%81%a8%e3%81%9d%e3%82%8c%e3%81%8c%e9%96%a2%e4%bf%82%e3%81%99%e3%82%8b%e4%ba%8b%e8%b1%a1","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%aa%81%e7%84%b6%e5%a4%89%e7%95%b0%e3%81%ae%e4%bd%8d%e7%bd%ae%e3%81%a8%e3%81%9d%e3%82%8c%e3%81%8c%e9%96%a2%e4%bf%82%e3%81%99%e3%82%8b%e4%ba%8b%e8%b1%a1\/","title":{"rendered":"SARS-CoV-2\u306b\u304a\u3051\u308b\u7a81\u7136\u5909\u7570\u306e\u4f4d\u7f6e\u3068\u305d\u308c\u304c\u95a2\u4fc2\u3059\u308b\u4e8b\u8c61\u306e\u30d1\u30bf\u30fc\u30f3\u5316"},"content":{"rendered":"

University of Florida College of Medicine, Gainesville, FL, USA\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306b\u304a\u3051\u308b\u7a81\u7136\u5909\u7570\u306e\u4f4d\u7f6e\u3068\u305d\u308c\u304c\u95a2\u4fc2\u3059\u308b\u4e8b\u8c61\u306b\u3064\u3044\u3066\u30d1\u30bf\u30fc\u30f3\u5316\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8606318\/<\/a><\/p>\n

RBD\u306b\u304a\u3051\u308b\u5909\u7570<\/strong>
\nRBD\u5909\u7570\uff08K417 N\u3001L452R\u3001E484K\u306a\u3069\uff09\u306f\u3001\u4e2d\u548c\u6297\u4f53\u7d50\u5408\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u4f8b\u3048\u3070\u3001N501Y\u3068\u3044\u3046RBD\u306e\u5909\u7570\u306f\u3001\u5bbf\u4e3b\u53d7\u5bb9\u4f53ACE2\u306b\u5bfe\u3059\u308bSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u89aa\u548c\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306eS1 NTD\u304a\u3088\u3073RBD\u3067\u7372\u5f97\u3055\u308c\u305f\u3053\u308c\u3089\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u6709\u5229\u306a\u5909\u7570\u306f\u3001\u5bbf\u4e3b\u53d7\u5bb9\u4f53\u3084\u88dc\u52a9\u53d7\u5bb9\u4f53\u306e\u7d50\u5408\u3092\u5f37\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

NTD\u306b\u304a\u3051\u308b\u5909\u7570<\/strong>
\n\u4f55\u6545RBD\u306e\u5909\u7570\u304c\uff08\u4e2d\u548c\u6297\u4f53\u3068\u5bbf\u4e3b\u7d30\u80de\u306eACE2\u7d50\u5408\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\uff09\u30a6\u30a4\u30eb\u30b9\u306e\u9069\u5fdc\u5ea6\u3092\u5909\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u7406\u7531\u306f\u660e\u3089\u304b\u306a\u306e\u3067\u3059\u304c\u3001\u4f55\u6545\u30a6\u30a4\u30eb\u30b9\u306b\u3068\u3063\u3066\u6709\u5229\u306a\u5909\u7570\u304cNTD\u306b\u51fa\u73fe\u3057\u3066\u3044\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u305d\u306e\u7406\u7531\u306f\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002SARS-CoV-2\u306b\u304a\u3044\u3066\u306f\u3001NTD\u3092\u542b\u3080Spike\u30bf\u30f3\u30d1\u30af\u8cea\u4e0a\u306e\u8907\u6570\u306e\u30a8\u30d4\u30c8\u30fc\u30d7\u306b\u7d50\u5408\u3059\u308b\u4e2d\u548c\u6297\u4f53\u304c\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001NTD\u304c\u30a6\u30a4\u30eb\u30b9\u306e\u611f\u67d3\u9069\u5408\u6027\u306b\u95a2\u9023\u3059\u308b\u91cd\u8981\u3067\u3042\u308b\u304c\u672a\u77e5\u306e\u6a5f\u80fd\uff08\u88dc\u52a9\u53d7\u5bb9\u4f53\u7d50\u5408\u306a\u3069\uff09\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u975e\u5e38\u306b\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

Spike\u30bf\u30f3\u30d1\u30af\u8cea\u4e09\u91cf\u4f53\u9593\u306e\u63a5\u89e6\u90e8\u306b\u304a\u3051\u308b\u5909\u7570<\/strong>
\nA570D\u3001D614G\u3001A701V\u3001D950 N\u3001\u304a\u3088\u3073S982A\u306f\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u4e09\u91cf\u4f53\u9593\u306e\u63a5\u89e6\u90e8\u306b\u5b58\u5728\u3057\u307e\u3059\u3002\u30b9\u30d1\u30a4\u30af\u4e09\u91cf\u4f53\u754c\u9762\u3067\u306e\u7f6e\u63db\u306f\u3001\u5206\u5b50\u9593\u7d50\u5408\u89aa\u548c\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u90e8\u4f4d\u306b\u767a\u751f\u3057\u305f\u5909\u7570\u306f\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5207\u65ad\u3001\u69cb\u9020\u306e\u518d\u914d\u5217\u3001\u5bbf\u4e3b\u7d30\u80de\u819c\u3068\u306e\u878d\u5408\u30e1\u30ab\u30cb\u30ba\u30e0\u306a\u3069\u3001\u52d5\u7684\u306a\u30a6\u30a4\u30eb\u30b9\u30d7\u30ed\u30bb\u30b9\u3092\u5f37\u5316\u3059\u308b\u65b9\u6cd5\u3067Spike\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4e0d\u5b89\u5b9a\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

furin cleavage site\u306b\u304a\u3051\u308b\u5909\u7570<\/strong>
\nSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306e681\u4f4d\u306e\u5909\u7570\u306f\u3001\u611f\u67d3\u529b\u306e\u9ad8\u3044\u30a2\u30eb\u30d5\u30a1\u304a\u3088\u3073\u30c7\u30eb\u30bf\u5909\u7570\u682a\u306b\u898b\u3089\u308c\u307e\u3059\u304c\u3001\u611f\u67d3\u6027\u306e\u4f4e\u3044\u5909\u7570\u4f53\u3067\u3042\u308b\u30d9\u30fc\u30bf\u304a\u3088\u3073\u30ac\u30f3\u30de\u306b\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3002681\u4f4d\u306f\u3001RRAR\u30d7\u30ed\u30bf\u30f3\u30d1\u30af\u8cea\u8ee2\u63db\u30e2\u30c1\u30fc\u30d5\uff08\u30d5\u30e5\u30fc\u30ea\u30f3\u5207\u65ad\u90e8\u4f4d\uff09\u306b\u96a3\u63a5\u3057\u3066\u4f4d\u7f6e\u3057\u3066\u3044\u307e\u3059\u3002\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306eS1\/S2\u5207\u65ad\u306f\u9178\u6027\u4e0b\u306e\u74b0\u5883\u3067\u767a\u751f\u3059\u308b\u305f\u3081\u3001\u611f\u67d3\u529b\u306e\u9ad8\u3044\u5909\u7570\u4f53\uff08\u30a2\u30eb\u30d5\u30a1\u306e\u30d2\u30b9\u30c1\u30b8\u30f3\u3001\u30c7\u30eb\u30bf\u306e\u30a2\u30eb\u30ae\u30cb\u30f3\uff09\u306e681\u4f4d\u306b\u3042\u308b\u6b63\u306b\u5e2f\u96fb\u3057\u305f\u30a2\u30df\u30ce\u9178\u306f\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5207\u65ad\u901f\u5ea6\u3068\u305d\u308c\u306b\u7d9a\u304f\u819c\u878d\u5408\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

University of Florida College of Medicine, Gainesville, FL, USA\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306b\u304a\u3051\u308b\u7a81\u7136\u5909\u7570\u306e\u4f4d\u7f6e\u3068\u305d\u308c\u304c\u95a2\u4fc2\u3059\u308b\u4e8b\u8c61\u306b\u3064\u3044\u3066\u30d1\u30bf\u30fc\u30f3\u5316<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-6954","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6954"}],"version-history":[{"count":13,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6954\/revisions"}],"predecessor-version":[{"id":6975,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6954\/revisions\/6975"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}