{"id":6890,"date":"2021-11-22T12:18:11","date_gmt":"2021-11-22T03:18:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6890"},"modified":"2021-11-22T13:58:43","modified_gmt":"2021-11-22T04:58:43","slug":"%e7%9c%9f%e8%8f%8c%e8%a1%a8%e9%9d%a2%e3%81%ae%e5%a4%9a%e7%b3%96%e9%a1%9e-%ce%b1-13-%e3%82%b0%e3%83%ab%e3%82%ab%e3%83%b3%e3%80%81%ce%b2-13-%e3%82%b0%e3%83%ab%e3%82%ab%e3%83%b3%e3%81%8cwnt-%ce%b2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e7%9c%9f%e8%8f%8c%e8%a1%a8%e9%9d%a2%e3%81%ae%e5%a4%9a%e7%b3%96%e9%a1%9e-%ce%b1-13-%e3%82%b0%e3%83%ab%e3%82%ab%e3%83%b3%e3%80%81%ce%b2-13-%e3%82%b0%e3%83%ab%e3%82%ab%e3%83%b3%e3%81%8cwnt-%ce%b2\/","title":{"rendered":"\u771f\u83cc\u8868\u9762\u306e\u591a\u7cd6\u985e \u03b1-(1,3)-\u30b0\u30eb\u30ab\u30f3\u3001\u03b2-(1,3)-\u30b0\u30eb\u30ab\u30f3\u304c\u6a39\u72b6\u7d30\u80de\u306eWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306b\u95a2\u308f\u308b"},"content":{"rendered":"<p>Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre de Recherch\u00e9 des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 de Paris, France\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6a39\u72b6\u7d30\u80de\u306b\u304a\u3044\u3066\u3001C-\u578b\u30ec\u30af\u30c1\u30f3\u304cWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u3067\u3042\u308a\u3001\u771f\u83cc\u8868\u9762\u306b\u304a\u3044\u3066\u306f\u3001\u30ad\u30c1\u30f3\u3067\u306f\u306a\u304f\u3001\u591a\u7cd6\u985e \u03b2-(1, 3)-\u30b0\u30eb\u30ab\u30f3\u3001\u03b1-(1, 3)-\u30b0\u30eb\u30ab\u30f3\u304c\u3053\u306e\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02824-21\">https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02824-21<\/a><\/p>\n<p>\u30a2\u30b9\u30da\u30eb\u30ae\u30eb\u30b9\u30fb\u30d5\u30df\u30ac\u30fc\u30c4\u30b9 (Aspergillus fumigatus)\u306f\u3001\u7a7a\u4e2d\u306b\u904d\u5728\u3059\u308b\u771f\u83cc\u3067\u3042\u308a\u307e\u3059\u3002\u901a\u5e38\u306f\u3001\u5065\u5e38\u8005\u3067\u3042\u308c\u3070\u3001\u5438\u3044\u8fbc\u3093\u3067\u3082\u6392\u9664\u3055\u308c\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u304c\u3001\u6642\u306b\u3088\u308a\u3001\u904e\u654f\u75c7\u3001\u771f\u83cc\u611f\u67d3\u306b\u3088\u308b\u91cd\u5ea6\u306e\u5598\u606f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u6c17\u7ba1\u652f\u708e\u3001\u5909\u5316\u3057\u305f\u80ba\u4e0a\u76ae\u7d30\u80de\u306e\u30b3\u30ed\u30cb\u30fc\u5f62\u6210\u3001\u65e2\u5b58\u306e\u80da\u75c5\u5909\u306b\u304a\u3051\u308b\u30a2\u30b9\u30da\u30eb\u30ae\u30eb\u30b9\u816b\u3089\u3092\u5f15\u304d\u8d77\u3053\u3059\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u6a39\u72b6\u7d30\u80de\u3001\u597d\u4e2d\u7403\u3089\u306e\u81ea\u7136\u514d\u75ab\u7d30\u80de\u304c\u3001A. fumigatus\u306b\u5bfe\u3059\u308b\u6297\u771f\u83cc\u6d3b\u6027\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u771f\u83cc\u304c\u5165\u3063\u3066\u304f\u308b\u3068\u3001\u6a39\u72b6\u7d30\u80de\u304c\u6301\u3064\u69d8\u3005\u306a\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\uff08PRRs\uff09\u304c\u4fb5\u5165\u3057\u3066\u304d\u305f\u771f\u83cc\u3092\u8a8d\u8b58\u3057\u307e\u3059\u3002A. fumigatus\u3092\u8a8d\u8b58\u3067\u304d\u308b\u6a39\u72b6\u7d30\u80de\u304c\u3001\u5f15\u304d\u7d9a\u3044\u3066CD4+ T-\u7d30\u80de\u3092Th1\u3001Th2\u3001Th17\u3001oxP3+ \u5236\u5fa1\u6027T-\u7d30\u80de\u3089\u3078\u3068\u5206\u5316\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u4e2d\u3067\u3001Th2 \u3084 Th17 \u5fdc\u7b54\u306f\u3001A. fumigatus\u306e\u611f\u67d3\u306b\u5bfe\u3057\u3066\u306f\u975e\u4fdd\u8b77\u7684\u3067\u3059\u3002 Th1 \u304c\u9632\u5fa1\u514d\u75ab\u5fdc\u7b54\u306e\u8a98\u5c0e\u306b\u4e3b\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u5236\u5fa1\u6027T-\u7d30\u80de\u306f\u3001\u514d\u75ab\u6291\u5236\u7684\u3067\u3042\u308a\u6162\u6027\u7684\u304b\u3064\u6301\u7d9a\u7684\u306a\u611f\u67d3\u75c7\u3092\u4fc3\u9032\u3057\u307e\u3059\u304c\u3001\u305d\u308c\u3089\u306f\u307e\u305f\u708e\u75c7\u6027\u306e\u7d44\u7e54\u30c0\u30e1\u30fc\u30b8\u3092\u62bc\u3055\u3048\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001Th1\u3068\u5236\u5fa1\u6027T-\u7d30\u80de\u306e\u30d0\u30e9\u30f3\u30b9\u304cA. fumigatus\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u514d\u75ab\u53cd\u5fdc\u306b\u3068\u3063\u3066\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001IL-10\u3001TGF-\u03b2\u3001\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\u306e\u7523\u751f\u3068\u3044\u3063\u305f\u5404\u7a2e\u306e\u6297\u708e\u75c7\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u4ecb\u3057\u305f\u6a39\u72b6\u7d30\u80de\u306e\u5bdb\u5bb9\u539f\u751f\u6a5f\u80fd\u3084\u5236\u5fa1\u6027T-\u7d30\u80de\u53cd\u5fdc\u306e\u4fc3\u9032\u306b\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>A. fumigatus \u3092\u30e2\u30c7\u30eb\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u6b21\u306e\u3088\u3046\u306a\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002 \u771f\u83cc\u7a2e\u304c\u3001Wnt\u30ea\u30ac\u30f3\u30c9Wnt1\u304a\u3088\u3073Wnt7a\u306e\u5206\u6ccc\u3068\u3068\u3082\u306b\u3001\u6a39\u72b6\u7d30\u80deC\u306eWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001Wnt\u7d4c\u8def\u306e\u963b\u5bb3\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u5206\u6ccc\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306a\u304f\u3001\u6a39\u72b6\u7d30\u80de\u306e\u6210\u719f\u3092\u62bc\u3055\u3048\u3001\u6297\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3IL-10\u306e\u9078\u629e\u7684\u963b\u5bb3\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002\u6a39\u72b6\u7d30\u80de\u306b\u304a\u3051\u308bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u7121\u52b9\u5316\u306f\u3001\u4ed6\u306eCD4 + T\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u5206\u6975\u3092\u5909\u3048\u308b\u3053\u3068\u306a\u304f\u3001\u5236\u5fa1\u6027T\u7d30\u80de\u306e\u5206\u6975\u3092\u6291\u5236\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u3057\u3066\u307e\u305f\u3001\u6a39\u72b6\u7d30\u80de\u306b\u304a\u3051\u308bC-\u578b\u30ec\u30af\u30c1\u30f3\u304c\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u8a98\u5c0e\u306b\u306f\u5fc5\u8981\u3067\u3042\u308a\u3001A. fumigatus\u8868\u9762\u306e\u591a\u7cd6\u985e\u03b2-(1, 3)-\u30b0\u30eb\u30ab\u30f3\u3001\u03b1-(1, 3)-\u30b0\u30eb\u30ab\u30f3\u304c\u3001\u30ad\u30c1\u30f3\u3067\u306f\u306a\u304f\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/Wnt-signaling_fungi-300x144.png\" alt=\"\" width=\"300\" height=\"144\" class=\"alignnone size-medium wp-image-6893\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/Wnt-signaling_fungi-300x144.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/Wnt-signaling_fungi.png 491w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>\u3000where, CA=unstimulated, SC=stimulated with swollen conidia<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre de Recherch\u00e9 des Cordeliers, Sorbonne Univer<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e7%9c%9f%e8%8f%8c%e8%a1%a8%e9%9d%a2%e3%81%ae%e5%a4%9a%e7%b3%96%e9%a1%9e-%ce%b1-13-%e3%82%b0%e3%83%ab%e3%82%ab%e3%83%b3%e3%80%81%ce%b2-13-%e3%82%b0%e3%83%ab%e3%82%ab%e3%83%b3%e3%81%8cwnt-%ce%b2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-6890","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dica\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/%e7%9c%9f%e8%8f%8c%e8%a1%a8%e9%9d%a2%e3%81%ae%e5%a4%9a%e7%b3%96%e9%a1%9e-%ce%b1-13-%e3%82%b0%e3%83%ab%e3%82%ab%e3%83%b3%e3%80%81%ce%b2-13-%e3%82%b0%e3%83%ab%e3%82%ab%e3%83%b3%e3%81%8cwnt-%ce%b2\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO 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