{"id":6814,"date":"2021-11-15T11:54:37","date_gmt":"2021-11-15T02:54:37","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6814"},"modified":"2021-11-15T11:54:37","modified_gmt":"2021-11-15T02:54:37","slug":"%e7%a5%9e%e7%b5%8c%e8%8a%bd%e8%85%ab%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bn-%e5%9e%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%81%ae%e9%81%95%e3%81%84%e3%81%8c%e8%85%ab%e7%98%8d%e3%81%ae%e5%a2%97%e6%ae%96","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e7%a5%9e%e7%b5%8c%e8%8a%bd%e8%85%ab%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bn-%e5%9e%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%81%ae%e9%81%95%e3%81%84%e3%81%8c%e8%85%ab%e7%98%8d%e3%81%ae%e5%a2%97%e6%ae%96\/","title":{"rendered":"\u795e\u7d4c\u82bd\u816b\u306b\u304a\u3051\u308bN-\u578b\u7cd6\u9396\u4fee\u98fe\u306e\u9055\u3044\u304c\u816b\u760d\u306e\u5897\u6b96\u3084\u6d78\u6f64\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>Department of Biochemistry and Molecular Biology, East Carolina University, Greenville, North Carolina, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u795e\u7d4c\u82bd\u816b\u306b\u304a\u3051\u308bN-\u578b\u7cd6\u9396\u4fee\u98fe\u306e\u5909\u5316\u304c\u3001\u816b\u760d\u306e\u5897\u6b96\u3084\u6d78\u6f64\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0259743\" rel=\"ugc\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0259743<\/a><\/p>\n<p>\u4e8c\u7a2e\u306e\u7570\u306a\u3063\u305fN-\u578b\u7cd6\u9396\u4fee\u98fe\u69cb\u9020\u3092\u6301\u3064\u795e\u7d4c\u82bd\u816b\u304c\u6bd4\u8f03\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3072\u3068\u3064\u306f\u3001Mgat1\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066N-\u578b\u7cd6\u9396\u4fee\u98fe\u3092\u4eba\u70ba\u7684\u306b\u5909\u5316\u3055\u305b\u305f\u7d30\u80de\u682a, NB_1(-Mgat1), \u3067\u3042\u308a\u3001Oligomannose\u578b\u306eN-\u578b\u7cd6\u9396\u306e\u307f\u3092\u767a\u73fe\u3057\u307e\u3059\u3002\u3082\u3046\u3072\u3068\u3064\u306f\u3001\u305d\u306e\u5143\u3068\u306a\u3063\u305f\u795e\u7d4c\u82bd\u816b\u7d30\u80de, NB_1, \u3067\u3042\u308a\u3001\u3088\u308a\u9ad8\u6b21\u306e\u8907\u5408\u578b\u3084\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u578b\u306eN-\u578b\u7cd6\u9396\u3092\u767a\u73fe\u3057\u307e\u3059\uff08\u4e0b\u56f3\u53c2\u7167\u3001GNL \u3084 ConA \u306f\u3001oligomannose\u578b\u306eN-\u578b\u7cd6\u9396\u306b\u9ad8\u3044\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u793a\u3057\u3001E-PHA \u3084L-PHA \u306f\u8907\u5408\u578b\u306eN-\u578b\u7cd6\u9396\u306b\u9ad8\u3044\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u6301\u3063\u3066\u3044\u307e\u3059\uff09\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/NB_1-and-NB_1-mutant_N-glycans.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/NB_1-and-NB_1-mutant_N-glycans-300x239.png\" alt=\"\" width=\"300\" height=\"239\" class=\"alignnone size-medium wp-image-6817\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/NB_1-and-NB_1-mutant_N-glycans-300x239.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/NB_1-and-NB_1-mutant_N-glycans.png 352w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u7d30\u80de\u306e\u5897\u6b96\u306f\u3001\u8907\u5408\u578b\u306eN-\u578b\u7cd6\u9396\u69cb\u9020\u3092\u6301\u3064 NB_1 \u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u305d\u308c\u3092\u6301\u305f\u306a\u3044 NB_1(-Mgat1) \u7d30\u80de\u3088\u308a\u3082\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u5b9a\u91cf\u7684\u306b\u306f\u3001NB_1(-Mgat1) \u7d30\u80de\u3068 NB_1 \u7d30\u80de\u306e\u9593\u3067\u300154\uff05\u306e\u4f4e\u4e0b\u304c\u898b\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>NB_1(-Mgat1) \u7d30\u80de\u306f\u3001NB_1 \u7d30\u80de\u3088\u308a\u3082\u9577\u3044\u7a81\u8d77\u3092\u6301\u3063\u3066\u304a\u308a\u3001oligomannose\u306e\u307f\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u306e\u65b9\u304c\u3001\u8907\u5408\u578b\u3084\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u578b\u3092\u6301\u3064\u7d30\u80de\u3088\u308a\u3082\u3088\u308a\u6d78\u6f64\u3057\u3084\u3059\u3044\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u816b\u760d\u7d30\u80de\u306e\u6d78\u6f64\u6027\u3092\u5b9a\u91cf\u5316\u3059\u308b\u70ba\u306b\u3001\u6d78\u6f64\u9762\u7a4d\u306e\u6bd4\u3092\u8a55\u4fa1\u3057\u305f\u3068\u3053\u308d\u3001 NB_1(-Mgat1) \u7d30\u80de\u306e\u65b9\u304c\u3001NB_1 \u7d30\u80de\u3088\u308a\u3082\u30012.3\u500d\u5927\u304d\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Biochemistry and Molecular Biology, East Carolina University, Greenville, North Carolina, USA\u3089\u306e\u30b0<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e7%a5%9e%e7%b5%8c%e8%8a%bd%e8%85%ab%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bn-%e5%9e%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%81%ae%e9%81%95%e3%81%84%e3%81%8c%e8%85%ab%e7%98%8d%e3%81%ae%e5%a2%97%e6%ae%96\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-6814","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6814"}],"version-history":[{"count":7,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6814\/revisions"}],"predecessor-version":[{"id":6822,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6814\/revisions\/6822"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}