{"id":678,"date":"2020-09-30T15:31:25","date_gmt":"2020-09-30T06:31:25","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=656"},"modified":"2020-10-03T10:55:53","modified_gmt":"2020-10-03T01:55:53","slug":"a-proposal-for-the-treatment-of-new-coronavirus-sras-cov-2-role-of-nk-cells","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-proposal-for-the-treatment-of-new-coronavirus-sras-cov-2-role-of-nk-cells\/","title":{"rendered":"A Proposal for the Treatment of New Coronavirus (SARS-CoV-2): Role of NK Cells"},"content":{"rendered":"

NK cells play an important role in viral infections. The University of Ferrari group proposes a treatment using anti-NKG2A antibodies based on the results of research on how NK cells behave in the case of a new coronavirus (SARS-CoV-2) infection.
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/32859121\/<\/a><\/p>\n

Infecting S protein of the new coronavirus (Spike 1 Protein and Spike 2 Protein) into lung epithelial cells and co-culturing with NK cells, they investigated the expression status of GATA3 (transcription factor), HLA-E (E class of human leukocyte antigen), NKG2A\/CD94 (NK cell inhibitory receptor), CD107a (degranulation: release of cytotoxic factor), and IFN-gamma. As a result, it was found that the following expression changes occurred.<\/p>\n

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  1. GATA3’s Advances<\/li>\n
  2. HLA-E’s Advance<\/li>\n
  3. NKG2A\/CD94’s Advance<\/li>\n
  4. Decrease in CD107a<\/li>\n
  5. Decrease in IFN-gamma<\/li>\n<\/ol>\n

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    These changes are caused by SP1 (Spike 1 Protein) of the S protein. Sp1 infection activates the transcription factor GATA3 and presents the SP1 peptide (8mer) on the cell surface by HLA-E. The combined HLA-E and NKG2A\/CD94 results in inhibitory signals in NK cells. At the same time, the release of cytotoxic factors has been suppressed, the release of IFN-gamma has been also suppressed, and thereby the immune system of virus elimination has been weakened.<\/p>\n

    Therefore, in conclusion, in the early stages of infection, it was proposed as a potentially effective treatment to dose anti-NKG2A antibody (monalizumab) in order to enhance immune activity.<\/p>\n","protected":false},"excerpt":{"rendered":"

    NK cells play an important role in viral infections. The University of Ferrari group proposes a treatment usin<\/p><\/div>\n

    \u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-678","post","type-post","status-publish","format-image","hentry","category-nature-en","post_format-post-format-image"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t