{"id":6715,"date":"2021-11-05T07:16:42","date_gmt":"2021-11-04T22:16:42","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6715"},"modified":"2021-11-05T07:16:42","modified_gmt":"2021-11-04T22:16:42","slug":"%e3%83%92%e3%83%88%e3%81%ae%e3%83%9e%e3%83%b3%e3%83%8e%e3%83%bc%e3%82%b9%e7%89%b9%e7%95%b0%e7%9a%84%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e3%81%9d%e3%82%8c%e3%81%9e%e3%82%8c%e3%82%92%e7%8b%99","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%83%92%e3%83%88%e3%81%ae%e3%83%9e%e3%83%b3%e3%83%8e%e3%83%bc%e3%82%b9%e7%89%b9%e7%95%b0%e7%9a%84%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e3%81%9d%e3%82%8c%e3%81%9e%e3%82%8c%e3%82%92%e7%8b%99\/","title":{"rendered":"\u30d2\u30c8\u306e\u30de\u30f3\u30ce\u30fc\u30b9\u7279\u7570\u7684\u30ec\u30af\u30c1\u30f3\u306e\u305d\u308c\u305e\u308c\u3092\u72d9\u3044\u6483\u3061\u3059\u308b\u30de\u30f3\u30ce\u30b7\u30eb\u5316\u9ad8\u5206\u5b50\u306e\u4eba\u5de5\u5408\u6210"},"content":{"rendered":"<p>Department of Chemistry, Massachusetts Institute of Technology, MS, USA\u3089\u306f\u3001\u30d2\u30c8\u306e\u30de\u30f3\u30ce\u30fc\u30b9\u7279\u7570\u7684\u30ec\u30af\u30c1\u30f3\u306e\u5404\u3005\u306b\u7279\u7570\u7684\u306a\u30de\u30f3\u30ce\u30b7\u30eb\u5316\u9ad8\u5206\u5b50\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8549053\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8549053\/<\/a><\/p>\n<p>\u7cd6\u9396\u7d50\u5408\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30ec\u30af\u30c1\u30f3\uff09\u306f\u3001\u75c5\u539f\u83cc\u306b\u7d50\u5408\u3057\u81ea\u7136\u514d\u75ab\u3092\u6d3b\u6027\u5316\u3059\u308b\u3088\u3046\u306b\u3001\u591a\u69d8\u306a\u7d30\u80de\u8a8d\u8b58\u3001\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u30ec\u30af\u30c1\u30f3\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3059\u308b\u3001\u7279\u306b\u514d\u75ab\u7d30\u80de\u8868\u9762\u306b\u767a\u73fe\u3059\u308b\u305d\u308c\u3089\u3092\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u514d\u75ab\u3084\u5275\u85ac\u306b\u5927\u304d\u304f\u8ca2\u732e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30ec\u30af\u30c1\u30f3\u306f\u591a\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u305d\u308c\u6545\u3001\u7d50\u5408\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u306e\u307b\u3068\u3093\u3069\u306f\u591a\u4fa1\u3067\u3042\u308a\u307e\u3059\u3002\u30ec\u30af\u30c1\u30f3\u3092\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u3059\u308b\u5834\u5408\u306e\u6709\u52b9\u306a\u65b9\u6cd5\u306f\u3001\u30dd\u30ea\u30de\u30fc\u3092\u30d0\u30c3\u30af\u30dc\u30fc\u30f3\u3068\u3057\u3066\u5358\u4e00\u306e\u7cd6\u9396\u30a8\u30d4\u30c8\u30fc\u30d7\u3092\u591a\u91cd\u306b\u4e57\u305b\u308b\u3053\u3068\u3067\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u306e\u3088\u3046\u306a\u591a\u4fa1\u306e\u30ea\u30ac\u30f3\u30c9\u306e\u6b20\u70b9\u3068\u3044\u3046\u306e\u306f\u3001\u5358\u7cd6\u7279\u7570\u6027\u3092\u5171\u6709\u3059\u308b\u30ec\u30af\u30c1\u30f3\u306e\u305d\u308c\u305e\u308c\u3092\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u306a\u3044\u3068\u3044\u3046\u4e8b\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u30de\u30f3\u30ce\u30fc\u30b9\u5358\u7cd6\u7279\u6027\u3092\u6301\u3064\u30ec\u30af\u30c1\u30f3\u306b\u306f\u3001DC-SIGN\u3001DC-SIGNR\u3001MBL\u3001SP-D\u3001langerin\u3001dectin-2\u3001mincle\u3001DEC-205\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u8457\u8005\u3089\u306f\u3001\u3053\u308c\u3089\u306e\u30de\u30f3\u30ce\u30fc\u30b9\u7279\u7570\u7684\u30ec\u30af\u30c1\u30f3\u3092\u3088\u308a\u6b63\u78ba\u306b\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u3067\u304d\u308b\u3088\u3046\u306a\u30de\u30f3\u30ce\u30b7\u30eb\u5316\u9ad8\u5206\u5b50\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u30de\u30f3\u30ce\u30b7\u30eb\u5316\u7cd6\u9ad8\u5206\u5b50\u3092\u751f\u6210\u3059\u308b\u305f\u3081\u306b\u3001\uff08R\uff09-\u307e\u305f\u306f\uff08S\uff09-\u30b0\u30ea\u30b7\u30b8\u30eb\u30d7\u30ed\u30d1\u30eb\u30ae\u30eb\u30a8\u30fc\u30c6\u30eb\uff08GPE\u3001> 99\uff05ee\uff09\u304b\u3089\u59cb\u307e\u308b\u53cd\u5fa9\u6307\u6570\u95a2\u6570\u7684\u6210\u9577\uff08IEG\uff09\u30b5\u30a4\u30af\u30eb\u3092\u5b9f\u884c\u3057\u3066\u3001\u6b63\u78ba\u306b8\u300116\u3001\u307e\u305f\u306f32\u306e\u30a2\u30ea\u30eb\u5074\u9396\u3092\u6301\u3064\u9ad8\u5206\u5b50\u3092\u4f5c\u308a\u4e0a\u3052\u307e\u3059\u3002\u3053\u306e\u6642\u306b\u3001\u3059\u3079\u3066\uff08R\uff09\uff08\u30a2\u30a4\u30bd\u30bf\u30af\u30c1\u30c3\u30af\uff09\u3001\u3059\u3079\u3066\uff08S\uff09\uff08\u30a2\u30a4\u30bd\u30bf\u30af\u30c1\u30c3\u30af\uff09\u3001\u304a\u3088\u3073\u4ea4\u4e92\uff08R-alt-S\uff09\uff08\u30b7\u30f3\u30b8\u30aa\u30bf\u30af\u30c1\u30c3\u30af\uff09\u306e3\u3064\u306e\u7570\u306a\u308b\u9ad8\u5206\u5b50\u69cb\u9020\u3092\u4f5c\u308a\u4e0a\u3052\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u3053\u306e\u9ad8\u5206\u5b50\u306b\u30de\u30f3\u30ce\u30fc\u30b9\u6b8b\u57fa\u3092\u4ed8\u52a0\u3059\u308b\u305f\u3081\u306b\u3001\u3053\u308c\u3089\u3092UV\u5149\uff08\u03bb= 365 nm\uff09\u4e0b\u3067\u03b2-\u30c1\u30aa\u30de\u30f3\u30ce\u30fc\u30b9\u30ca\u30c8\u30ea\u30a6\u30e0\u5869\u3068\u53cd\u5fdc\u3055\u305b\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/mannosylated-glyco-IGEmers\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/mannosylated-glyco-IGEmers-300x110.png\" alt=\"\" width=\"300\" height=\"110\" class=\"alignnone size-medium wp-image-6718\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/mannosylated-glyco-IGEmers-300x110.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/mannosylated-glyco-IGEmers-600x220.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/mannosylated-glyco-IGEmers-1024x375.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/mannosylated-glyco-IGEmers-768x281.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/mannosylated-glyco-IGEmers.png 1048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u7d50\u5408\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u9593\u3067\u6570\u30b1\u30bf\u4ee5\u4e0a\u5909\u308f\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001DC-SIGN\u306eK<sub>A<\/sub>\u5024\u306f\u3001(S)-8mer\u306b\u5bfe\u3057\u3066 1 \u00d7 10<sup>4<\/sup> \u304b\u3089(R)-16mer\u306b\u5bfe\u3057\u3066\u30011 \u00d7 10<sup>8<\/sup> \u306b\u307e\u3067\u5909\u5316\u3057\u3066\u3044\u307e\u3059\u3002Dectin-2\u306e\u5834\u5408\u3067\u3082\u30011 \u00d7 10<sup>4<\/sup> \u304b\u30891 \u00d7 10<sup>8<\/sup>\u306b\u5909\u5316\u3057\u3066\u3044\u307e\u3059\u3057\u3001DEC-205\u306e\u5834\u5408\u306b\u306f\u3001\u3059\u3079\u3066\u306e\u9ad8\u5206\u5b50\u306b 1 \u00d7 10<sup>6<\/sup> \u304b\u3089 1 \u00d7 10<sup>9<\/sup>\u3067\u5f37\u304f\u7d50\u5408\u3057\u3001(R)-32mer\u306e\u5834\u5408\u3067\u6700\u3082\u5f37\u3044\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc 2.2 \u00d7 10<sup>9<\/sup>\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u540c\u3058\u30de\u30f3\u30ce\u30fc\u30b9\u5358\u7cd6\u7279\u6027\u3092\u6301\u3064\u30ec\u30af\u30c1\u30f3\u306b\u5bfe\u3057\u3066\u3001\u5e83\u3044\u30ec\u30f3\u30b8\u306e\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u5b9f\u73fe\u3067\u304d\u3066\u3044\u308b\u3053\u3068\u306f\u9a5a\u7570\u7684\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Chemistry, Massachusetts Institute of Technology, MS, USA\u3089\u306f\u3001\u30d2\u30c8\u306e\u30de\u30f3\u30ce\u30fc\u30b9\u7279\u7570\u7684\u30ec\u30af\u30c1\u30f3\u306e\u5404\u3005\u306b\u7279\u7570\u7684\u306a\u30de\u30f3\u30ce\u30b7\u30eb\u5316\u9ad8\u5206\u5b50\u3092\u958b\u767a\u3057<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%83%92%e3%83%88%e3%81%ae%e3%83%9e%e3%83%b3%e3%83%8e%e3%83%bc%e3%82%b9%e7%89%b9%e7%95%b0%e7%9a%84%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e3%81%9d%e3%82%8c%e3%81%9e%e3%82%8c%e3%82%92%e7%8b%99\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-6715","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"Department of Chemistry, Massachusetts Institute of Tec\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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