{"id":6712,"date":"2021-11-02T13:21:07","date_gmt":"2021-11-02T04:21:07","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6712"},"modified":"2021-11-02T13:23:36","modified_gmt":"2021-11-02T04:23:36","slug":"snake-venom-dimeric-pla2-from-vipera-nikolskii-showed-high-antiviral-activity-against-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/snake-venom-dimeric-pla2-from-vipera-nikolskii-showed-high-antiviral-activity-against-sars-cov-2\/","title":{"rendered":"Snake venom (Dimeric PLA<sub>2s<\/sub>) from Vipera nikolskii showed high antiviral activity against SARS-CoV-2"},"content":{"rendered":"<p>A group from Department of Molecular Neuroimmune Signalling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, has reported that Snake venom (Dimeric PLA2) from Vipera nikolskii showed high antiviral activity against SARS-CoV-2.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34714362\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34714362\/<\/a><\/p>\n<p>Two types of Snake venom (Dimeric PLA2) from Vipera nikolskii (HDP-1, HDP-2, and its subunits, HDP-2I and HDP-2P) were evaluated as natural antiviral products.<br \/>\nComplete suppression of the infectivity of SARS-CoV-2 was observed when the viral stock was treated with HDP-2P even at 0.1 \u00b5g\/ml on Vero E6 cells.<br \/>\nOn the other hand, the highest but moderate cytotoxicity was manifested by HDP-2P which at 100 \u03bcg\/ml reduced cell viability on average by 51%. <\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/snake-venom_antivirus-property.png\"><img decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/snake-venom_antivirus-property-300x160.png\" alt=\"\" width=\"300\" class=\"alignnone size-medium wp-image-6703\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/snake-venom_antivirus-property-300x160.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/snake-venom_antivirus-property.png 547w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/snake-venom_cell-viability.png\"><img decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/snake-venom_cell-viability-300x292.png\" alt=\"\" width=\"200\" class=\"alignnone size-medium wp-image-6705\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/snake-venom_cell-viability-300x292.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/11\/snake-venom_cell-viability.png 333w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>These data highlight the potential of PLA2s as a natural product that could prove to be fruitful as the starting point for the development of antiviral drugs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Molecular Neuroimmune Signalling, Shemyakin-Ovchinnikov Institute of Bioorganic Che<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/snake-venom-dimeric-pla2-from-vipera-nikolskii-showed-high-antiviral-activity-against-sars-cov-2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-6712","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6712"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6712\/revisions"}],"predecessor-version":[{"id":6714,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6712\/revisions\/6714"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}