{"id":6666,"date":"2021-10-26T15:02:12","date_gmt":"2021-10-26T06:02:12","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6666"},"modified":"2021-10-26T15:12:33","modified_gmt":"2021-10-26T06:12:33","slug":"wga-lectin-could-inhibit-infection-with-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/wga-lectin-could-inhibit-infection-with-sars-cov-2\/","title":{"rendered":"WGA lectin could inhibit infection with SARS-CoV-2"},"content":{"rendered":"<p>A group from Institute of Virology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Erlangen, Germany, etc. has reported that WGA lectin could inhibit infection with SARS-CoV-2 with an IC<sub>50<\/sub> of <10 ng\/mL.\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8508056\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8508056\/<\/a><\/p>\n<p>Vero B4 cells were infected with the SARS-CoV-2PR-1 (Wuhan type) for 1 h and then treated with different concentrations of WGA. Cell culture supernatants were harvested after 3 days and virus production was analyzed via qRT-PCR and Western blot. Treatment with WGA led to a strong reduction of SARS-CoV-2 replication. A concentration of 10 \u00b5g\/mL WGA completely abolished the presence of viral RNA copies in cell culture supernatants. The inhibitory effect was observed in a dose-dependent manner and was confirmed by Western blot analysis, which revealed an even stronger and dose-responsive reduction of virion production upon treatment with WGA. Collectively, these data provide the first evidence that WGA exhibits antiviral activity against SARS-CoV-2 in Vero B4 cells, with an estimated IC<sub>50ub> of <10 ng\/mL.\n\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA-300x124.png\" alt=\"\" width=\"300\" height=\"124\" class=\"alignnone size-medium wp-image-6659\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA-300x124.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA-600x249.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA-768x319.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA.png 921w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>To analyze cytotoxicity of WGA, toxicity assays were performed in VERO B4 and Calu-3 cells. In Vero B4 cells, the TD<sub>50<\/sub> was \u2248 50 \u00b5g\/mL, resulting in a broad therapeutic window of at least three log stages. These data suggest that WGA could be used to inhibit infection with SARS-CoV-2 in vivo. Let&#8217;s expect future clinical studies on this matter.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Institute of Virology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Erlangen, Germany, etc. <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/wga-lectin-could-inhibit-infection-with-sars-cov-2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-6666","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6666"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6666\/revisions"}],"predecessor-version":[{"id":6668,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6666\/revisions\/6668"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}