{"id":6657,"date":"2021-10-26T15:02:12","date_gmt":"2021-10-26T06:02:12","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6657"},"modified":"2021-10-26T15:02:12","modified_gmt":"2021-10-26T06:02:12","slug":"wga%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%8csars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e6%ad%a2%e3%81%a7%e3%81%8d%e3%82%8b","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/wga%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%8csars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e6%ad%a2%e3%81%a7%e3%81%8d%e3%82%8b\/","title":{"rendered":"WGA\u30ec\u30af\u30c1\u30f3\u304cSARS-CoV-2\u306e\u611f\u67d3\u3092\u963b\u6b62\u3067\u304d\u308b"},"content":{"rendered":"<p>Institute of Virology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Erlangen, Germany\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001WGA\u30ec\u30af\u30c1\u30f3\u304cSARS-CoV-2\u306e\u611f\u67d3\u963b\u5bb3\u306b\u4f7f\u7528\u3067\u304d\u3001\u305d\u306eIC<sub>50<\/sub> \u306f\u300110 ng\/mL\u4ee5\u4e0b\u3067\u3042\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8508056\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8508056\/<\/a><\/p>\n<p>Vero B4\u7d30\u80de\u3092SARS-CoV-2PR-1\uff08\u6b66\u6f22\u578b\uff09\u306b1\u6642\u9593\u611f\u67d3\u3055\u305b\u305f\u5f8c\u3001\u3055\u307e\u3056\u307e\u306a\u6fc3\u5ea6\u306eWGA\u3067\u51e6\u7406\u3057\u307e\u3057\u305f\u3002 3\u65e5\u5f8c\u306b\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u3092\u56de\u53ce\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u7523\u751f\u91cf\u3092\u3001qRT-PCR\u304a\u3088\u3073\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u3092\u7528\u3044\u3066\u5206\u6790\u3057\u307e\u3057\u305f\u3002 WGA\u306b\u3088\u308b\u51e6\u7406\u306b\u3088\u3063\u3066\u3001SARS-CoV-2\u306e\u8907\u88fd\u306f\u5927\u5e45\u306b\u6291\u5236\u3055\u308c\u307e\u3057\u305f\u3002 10 \u00b5g\/mL WGA\u306e\u6fc3\u5ea6\u3067\u3001\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u4e2d\u306e\u30a6\u30a4\u30eb\u30b9RNA\u30b3\u30d4\u30fc\u306f\u5b8c\u5168\u306b\u6d88\u5931\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u963b\u5bb3\u52b9\u679c\u306fWGA\u306e\u30c9\u30fc\u30ba\u306b\u7dba\u9e97\u306b\u4f9d\u5b58\u3057\u3066\u304a\u308a\u3001\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u5206\u6790\u306b\u3088\u308b\u78ba\u8a8d\u3067\u306f\u3001WGA\u3067\u306e\u51e6\u7406\u306b\u3088\u308b\u30a6\u30a4\u30eb\u30b9\u7523\u751f\u91cf\u306e\u6e1b\u5c11\u306f\u3088\u308a\u5f37\u304fWGA\u306e\u30c9\u30fc\u30ba\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001WGA\u304cVero B4\u7d30\u80de\u3067SARS-CoV-2\u306b\u5bfe\u3057\u3066\u5f37\u3044\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3057\u3001IC<sub>50<\/sub>\u304c10ng\/mL\u4ee5\u4e0b\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u521d\u3081\u3066\u793a\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA-300x124.png\" alt=\"\" width=\"300\" height=\"124\" class=\"alignnone size-medium wp-image-6659\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA-300x124.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA-600x249.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA-768x319.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/Inhibition-of-SARS-CoV-2-infection-with-WGA.png 921w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>WGA\u306e\u7d30\u80de\u6bd2\u6027\u3092\u78ba\u8a8d\u3059\u308b\u70ba\u306b\u3001Vero B4\u3068Calu-3\u7d30\u80de\u3092\u7528\u3044\u3066\u7d30\u80de\u6bd2\u6027\u30a2\u30c3\u30bb\u30a4\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002Vero B4\u7d30\u80de\u306e\u5834\u5408\u3067\u3001TD<sub>50<\/sub> \u306f\u3001\u51e1\u305d 50 \u00b5g\/mL\u3067\u3042\u308a\u3001\u3053\u306e\u3053\u3068\u306f\u4e09\u6841\u306b\u6e21\u308b\u5e83\u3044\u6cbb\u7642\u30a6\u30a4\u30f3\u30c9\u30fc\u304c\u5b58\u5728\u3057\u3001in vivo\u3067WGA\u3092SARS-CoV-2\u306e\u611f\u67d3\u3092\u62bc\u3055\u3048\u308b\u305f\u3081\u306b\u4f7f\u3048\u308b\u53ef\u80fd\u6027\u3092\u5927\u3044\u306b\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306e\u81e8\u5e8a\u7814\u7a76\u306b\u671f\u5f85\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Institute of Virology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Erlangen, Germany\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001WGA\u30ec\u30af\u30c1\u30f3\u304cSARS<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/wga%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%8csars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e6%ad%a2%e3%81%a7%e3%81%8d%e3%82%8b\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-6657","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6657","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6657"}],"version-history":[{"count":8,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6657\/revisions"}],"predecessor-version":[{"id":6670,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6657\/revisions\/6670"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}