{"id":6610,"date":"2021-10-24T08:58:16","date_gmt":"2021-10-23T23:58:16","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6610"},"modified":"2021-10-25T06:51:47","modified_gmt":"2021-10-24T21:51:47","slug":"sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%82%92%e6%8a%91%e6%ad%a2%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ab%e5%a4%a9%e7%84%b6%e7%89%a9%e3%81%a7%e3%82%aa%e3%83%bc%e3%83%88%e3%83%95%e3%82%a1%e3%82%b8","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%82%92%e6%8a%91%e6%ad%a2%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ab%e5%a4%a9%e7%84%b6%e7%89%a9%e3%81%a7%e3%82%aa%e3%83%bc%e3%83%88%e3%83%95%e3%82%a1%e3%82%b8\/","title":{"rendered":"SARS-CoV-2\u306e\u611f\u67d3\u3092\u6291\u6b62\u3059\u308b\u305f\u3081\u306b\u5929\u7136\u7269\u3067\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u963b\u5bb3\u3059\u308b"},"content":{"rendered":"<p>Universit\u00e0 del Piemonte Orientale, Department of Health Sciences, Novara, Italy\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u611f\u67d3\u304c\u3001\u30d9\u30eb\u30d9\u30ea\u30f3\u3001\u30d0\u30a4\u30ab\u30ea\u30f3\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u3001\u30ab\u30c6\u30ad\u30f3\u3001\u30d7\u30ed\u30b7\u30a2\u30cb\u30b8\u30f3\u3068\u8a00\u3063\u305f\u5929\u7136\u7269\u3067\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6291\u3048\u3089\u308c\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8516241\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8516241\/<\/a><\/p>\n<p>SARS-CoV-2\u304c\u7d30\u80de\u306b\u5165\u308a\u3001\u7d30\u80de\u5185\u3067\u8907\u88fd\u3057\u3001\u7d30\u80de\u304b\u3089\u51fa\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u6b21\u306e\u3088\u3046\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\uff081\uff09\u7c21\u5358\u306b\u8a00\u3046\u3068\u3001\u30a6\u30a4\u30eb\u30b9\u4fb5\u5165\u306e\u4e3b\u306a\u7d4c\u8def\u306f\u3001\u30af\u30e9\u30b9\u30ea\u30f3\u4ecb\u5728\u6027\u307e\u305f\u306f\u30af\u30e9\u30b9\u30ea\u30f3\/\u30ab\u30d9\u30aa\u30e9\u975e\u4f9d\u5b58\u6027\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3067\u3059\u3002\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3055\u308c\u305f\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u5206\u89e3\u306e\u305f\u3081\u306b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u30fb\u30ea\u30bd\u30bd\u30fc\u30e0\u306b\u9001\u308a\u5c4a\u3051\u3089\u308c\u308b\u306e\u3067\u3059\u304c\u3001\u30ab\u30c6\u30d7\u30b7\u30f3L\u3092\u4ecb\u3057\u305fS\u306e\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u304a\u3088\u3073\u30a6\u30a4\u30eb\u30b9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7-\u819c\u878d\u5408\u306e\u969b\u306b\u3001\u30a6\u30a4\u30eb\u30b9RNA\u306f\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5c0f\u80de\u304b\u3089\u8131\u51fa\u3057\u3001\u7d30\u80de\u8cea\u4e2d\u306b\u30a8\u30b9\u30b1\u30fc\u30d7\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\uff082\uff09\u3055\u3089\u306b\u3001\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u3068\u5bbf\u4e3b\u7d30\u80de\u819c\u306e\u878d\u5408\u306b\u3088\u3063\u3066\u3082\u7d30\u80de\u306b\u4fb5\u5165\u3057\u307e\u3059\u3002 ACE2\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u306f\u3001S\u30bf\u30f3\u30d1\u30af\u8ceaRBD\u3068\u306e\u5f37\u3044\u76f8\u4e92\u4f5c\u7528\u3092\u4ecb\u3057\u3066SARS-CoV-2\u611f\u67d3\u306e\u6a19\u7684\u3068\u306a\u308a\u307e\u3059\u3002<br \/>\n\uff083\uff09\u7d30\u80de\u306b\u5165\u308b\u7d4c\u8def\u304c\u4e0a\u8a18\u306e\u3069\u3061\u3089\u3067\u3042\u3063\u3066\u3082\u3001\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u30ab\u30c6\u30d7\u30b7\u30f3L\u3001\u30d5\u30e5\u30fc\u30ea\u30f3\u3001\u30c8\u30ea\u30d7\u30b7\u30f3\u3001\u819c\u8cab\u901a\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc2\uff08TMPRSS-2\uff09\u3001\u307e\u305f\u306f\u30c8\u30ea\u30d7\u30b7\u30f3\u69d8\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306f\u3001S\u30bf\u30f3\u30d1\u30af\u8cea\u3092S1\u304a\u3088\u3073S2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306b\u5207\u65ad\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u3068\u5bbf\u4e3b\u7d30\u80de\u819c\uff08\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u307e\u305f\u306f\u30d7\u30e9\u30ba\u30de\u30e1\u30f3\u30d6\u30ec\u30f3\uff09\u3068\u306e\u878d\u5408\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u306e\u5bbf\u4e3b\u7d30\u80de\u8cea\u4e2d\u3078\u306e\u653e\u51fa\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002<\/p>\n<p>\u5f93\u3063\u3066\u3001\u3053\u306e\u30a6\u30a4\u30eb\u30b9\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u30b9\u30c6\u30c3\u30d7\u306e\u963b\u5bb3\u306f\u3001\u7d30\u80de\u306e\u611f\u67d3\u30a6\u30a4\u30eb\u30b9\u91cf\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002\u4ee5\u4e0b\u306f\u3001\u3053\u306e\u76ee\u7684\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u5178\u578b\u7684\u306a\u5929\u7136\u7269\u3067\u3059\u3002<\/p>\n<p><strong>\u30d9\u30eb\u30d9\u30ea\u30f3<\/strong><br \/>\n\u30d9\u30eb\u30d9\u30ea\u30f3\u306fSARS-CoV-23CL<sup>PRO<\/sup>\u3001S\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u304a\u3088\u3073ACE2\u53d7\u5bb9\u4f53\u3068\u7d50\u5408\u3057\u3001\u30d9\u30eb\u30d9\u30ea\u30f3\u304c\u30a6\u30a4\u30eb\u30b9\u306e\u4fb5\u5165\u3068\u7d30\u80de\u819c\u878d\u5408\u3092\u9632\u304e\u30013CL<sup>PRO<\/sup>\u3092\u4ecb\u3057\u305fnsps4\uff5e16\u306e\u751f\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u30d7\u30ed\u30bb\u30b9\u3068\u4e8c\u91cd\u819c\u5c0f\u80de\u306e\u751f\u5408\u6210\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002 <\/p>\n<p><strong>\u30d0\u30a4\u30ab\u30ea\u30f3<\/strong><br \/>\n\u30d0\u30a4\u30ab\u30ea\u30f3\u306fSARS-CoV-2 S\u3001\u304a\u3088\u3073PL<sup>PRO<\/sup>\u3001nsp4\u3001\u304a\u3088\u30733CL<sup>PRO <\/sup>\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u8a98\u767a\u3092\u9632\u304e\u307e\u3059\u3002<\/p>\n<p><strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/strong><br \/>\n\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u3068\u305d\u306e\u8a98\u5c0e\u4f53\u306f\u3001SARS-CoV-2 S\u30bf\u30f3\u30d1\u30af\u8cea\u3001PL<sup>PRO<\/sup>\u3001RdRp\u3001\u304a\u3088\u3073S\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5f37\u304f\u963b\u5bb3\u3057\u307e\u3059\u3002\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306fACE2\u53d7\u5bb9\u4f53\u963b\u5bb3\u5264\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001S1\/ACE2\u8907\u5408\u4f53\u306e\u5f62\u6210\u3068\u30a6\u30a4\u30eb\u30b9\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3001\u304a\u3088\u3073\u4e8c\u91cd\u819c\u5c0f\u80de\u306e\u751f\u5408\u6210\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306f\u3001PL<sup>PRO<\/sup>\u3092\u4ecb\u3057\u305fnsp\u306e\u751f\u6210\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u30d7\u30ed\u30bb\u30b9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n<p><strong>\u30ab\u30c6\u30ad\u30f3<\/strong><br \/>\n\u30ab\u30c6\u30ad\u30f3\u306f\u30013CL<sup>PRO<\/sup>\u3001S\u30bf\u30f3\u30d1\u30af\u8ceaRBD\u3001ACE2\u3001S\/ACE2\u8907\u5408\u4f53\u3001\u30ab\u30c6\u30d7\u30b7\u30f3L\u3001nsp6\u3001\u304a\u3088\u3073N\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4e2d\u548c\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001SARS-CoV-2\u306e\u611f\u67d3\u3068\u8907\u88fd\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u30a8\u30d4\u30ac\u30ed\u30ab\u30c6\u30ad\u30f3-3-O-\u30ac\u30ec\u30fc\u30c8\uff08EGCG\uff09\u3084\u30c6\u30a2\u30d5\u30e9\u30d3\u30f33,3 &#8216;\u30b8\u30ac\u30ec\u30fc\u30c8\u306a\u3069\u306e\u8336\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306f\u30013CL<sup>PRO<\/sup>\u3001S\u30bf\u30f3\u30d1\u30af\u8cea\u3001S\/ACE2\u8907\u5408\u4f53\u3001PL<sup>PRO<\/sup>\u3001\u304a\u3088\u3073RdRp\u306b\u7d50\u5408\u3057\u3066\u963b\u5bb3\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><strong>\u30d7\u30ed\u30b7\u30a2\u30cb\u30b8\u30f3<\/strong><br \/>\n\u30d7\u30ed\u30b7\u30a2\u30cb\u30b8\u30f3\u306fSARS-CoV-2 3CL<sup>PRO<\/sup>\u3001nsp1\u3001nsp2\u3001PL<sup>PRO<\/sup>\u3001nsp4\u3001nsp6\u3001nsp7\u3001nsp8\u3001nsp9\u3001nsp10\u3001RdRp\u3001\u30d8\u30ea\u30ab\u30fc\u30bc\u3001\u30a8\u30af\u30bd\u30f3N\u3001NendoU\u30012&#8242;-O-MT\u3001ORF3a\u3001E\u30bf\u30f3\u30d1\u30af\u8cea\u3001M\u30bf\u30f3\u30d1\u30af\u8cea\u3001ORF6\u3001ORF7a\u3001ORF8\u3001N\u30bf\u30f3\u30d1\u30af\u8cea\u3001ORF10\u3001ACE2\u3001\u304a\u3088\u3073S\u30bf\u30f3\u30d1\u30af\u8cea\u3089\u306b\u5f37\u304f\u7d50\u5408\u3057\u963b\u5bb3\u3057\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Universit\u00e0 del Piemonte Orientale, Department of Health Sciences, Novara, Italy\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u611f\u67d3\u304c\u3001\u30d9\u30eb\u30d9\u30ea\u30f3\u3001\u30d0\u30a4<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e6%84%9f%e6%9f%93%e3%82%92%e6%8a%91%e6%ad%a2%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ab%e5%a4%a9%e7%84%b6%e7%89%a9%e3%81%a7%e3%82%aa%e3%83%bc%e3%83%88%e3%83%95%e3%82%a1%e3%82%b8\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-6610","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Universit\u00e0 del Piemonte Orientale, Department of Health\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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