{"id":6605,"date":"2021-10-23T08:42:07","date_gmt":"2021-10-22T23:42:07","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6605"},"modified":"2021-10-23T08:43:34","modified_gmt":"2021-10-22T23:43:34","slug":"%ce%b12-6sia-and-its-enzyme-st6gal1-are-upregurated-in-human-pancreatic-ductal-adenocarcinoma-pdac","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/%ce%b12-6sia-and-its-enzyme-st6gal1-are-upregurated-in-human-pancreatic-ductal-adenocarcinoma-pdac\/","title":{"rendered":"\u03b12-6Sia and its enzyme ST6GAL1 are upregurated in human Pancreatic ductal adenocarcinoma (PDAC)"},"content":{"rendered":"<p>A group from Department of Chemistry, University of Alberta, Edmonton, AB, Canada, etc. has reported that \u03b12-6Sia and its underlying enzyme ST6GAL1 as a potentially important glycan epitope in human Pancreatic ductal adenocarcinoma (PDAC).<br \/>\n<a href=\"https:\/\/www.mcponline.org\/article\/S1535-9476(21)00132-8\/fulltext\">https:\/\/www.mcponline.org\/article\/S1535-9476(21)00132-8\/fulltext<\/a><\/p>\n<p>Lectin Microarray:<br \/>\nIn PDAC, significant increases were observed in sialic acids, with changes in both \u03b12-6 (lectins: SNA, TJA-I, PSL, average increase: ~ 2.7 fold) and \u03b12-3sialosides (diCBM40, SLBR-H, SLBR-B, SLBR-N, MAL-I, MAA, ~ 3.4 fold).<br \/>\nCore fucosylation (PSA, LcH, ~ 2.7 fold) and bisecting GlcNAc (PHA-E, ~ 2.2 fold) and poly-LacNAc (WGA, DSA, LEA, \u223c 2.1 fold) also increased relative to normal. <\/p>\n<p>Glycosyltransferases:<br \/>\nStrong ST6GAL1 expression was observed in endothelial, immune cell and the cancerous ductal clusters. In addition, ST6GAL1 levels were associated with reduced survival. The \u03b12-3 sialyltransferase ST3GAL1 was also observed in many cell types, however it was not enriched in cancer-specific ductal cells.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/humanPDAC_glycosylation.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/humanPDAC_glycosylation-300x138.png\" alt=\"\" width=\"300\" height=\"138\" class=\"alignnone size-medium wp-image-6599\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/humanPDAC_glycosylation-300x138.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/humanPDAC_glycosylation-600x275.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/humanPDAC_glycosylation.png 647w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Chemistry, University of Alberta, Edmonton, AB, Canada, etc. has reported that \u03b12-6<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/%ce%b12-6sia-and-its-enzyme-st6gal1-are-upregurated-in-human-pancreatic-ductal-adenocarcinoma-pdac\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-6605","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6605"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6605\/revisions"}],"predecessor-version":[{"id":6607,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6605\/revisions\/6607"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}