{"id":6317,"date":"2021-10-02T08:56:25","date_gmt":"2021-10-01T23:56:25","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6317"},"modified":"2021-10-04T11:26:49","modified_gmt":"2021-10-04T02:26:49","slug":"%e5%8a%9b%e4%be%a1%e3%82%82%e9%ab%98%e3%81%8f%e5%a4%89%e7%95%b0%e3%81%ab%e3%82%82%e5%bc%b7%e3%81%84sars-cov-2-spike%e6%8a%97%e4%bd%93%e3%81%8c%e3%82%b9%e3%82%af%e3%83%aa%e3%83%bc%e3%83%b3%e3%81%95","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e5%8a%9b%e4%be%a1%e3%82%82%e9%ab%98%e3%81%8f%e5%a4%89%e7%95%b0%e3%81%ab%e3%82%82%e5%bc%b7%e3%81%84sars-cov-2-spike%e6%8a%97%e4%bd%93%e3%81%8c%e3%82%b9%e3%82%af%e3%83%aa%e3%83%bc%e3%83%b3%e3%81%95\/","title":{"rendered":"\u529b\u4fa1\u3082\u9ad8\u304f\u5909\u7570\u306b\u3082\u5f37\u3044SARS-CoV-2 Spike\u6297\u4f53\u304c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u305f"},"content":{"rendered":"<p>Vanderbilt University Medical Center, Nashville, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001LIBRA-seq \u6280\u8853\u3092\u7528\u3044\u3066\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u3053\u3068\u3067\u3001SARS-CoV-2\u306b\u5bfe\u3057\u3066\u529b\u4fa1\u3082\u9ad8\u304f\u5909\u7570\u306b\u3082\u5f37\u3044\u6297\u4f53\u3092\u5f97\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34592170\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34592170\/<\/a><\/p>\n<p>SARS-CoV-2 Spike\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u5f97\u308b\u305f\u3081\u306b\u3001\u8457\u8005\u3089\u306f\u512a\u308c\u305f\u6297\u4f53\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u30d7\u30ed\u30bb\u30b9\u3092\u7c21\u6613\u5316\u3059\u308b\u305f\u3081\u306b\u3001<strong>LIBRA-seq<\/strong>\u3068\u3044\u3046\u65b9\u6cd5\u3092\u63a1\u7528\u3057\u3066\u3044\u307e\u3059\u3002LIBRA-seq\u306f\u3001B\u7d30\u80de\u53d7\u5bb9\u4f53\u306e\u907a\u4f1d\u5b50\u914d\u5217\u3068\u6297\u539f\u3078\u306e\u53cd\u5fdc\u6027\u3092\uff11\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u9ad8\u901f\u306b\u540c\u6642\u6c7a\u5b9a\u3067\u304d\u308b\u65b9\u6cd5\u3067\u3059\u3002SARS-CoV-2 Spike\u6297\u539f\u306b\u7279\u7570\u7684\u306aB\u7d30\u80de\u306f\u3001RT-PCR\u3067\u967d\u6027\u3068\u3055\u308c\u3001\u611f\u67d33\u304b\u6708\u5f8c\u306b\u304a\u3044\u3066\u529b\u4fa1\u306e\u9ad8\u3044\u4e2d\u548c\u6297\u4f53\u3092\u6301\u3064\u3068\u3055\u308c\u308b\u30c9\u30ca\u30fc\u304b\u3089\u5358\u96e2\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>SARS-CoV-2 Spike\u306b\u5bfe\u3057\u3066\u9ad8\u3044LIBRA-seq\u30b9\u30b3\u30a2\u3092\u793a\u3057\u305f73\u500b\u306eIgG+ B \u7d30\u80de\u304b\u3089\u3001\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30e2\u30ce\u30af\u30ed\u6297\u4f53\u3092\u4f5c\u308b\u305f\u3081\u306e\u5019\u88dc\u3068\u3057\u30669\u7a2e\u304c\u9078\u5225\u3055\u308c\u307e\u3057\u305f\u3002\u7591\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u305fVSV\u30a2\u30c3\u30bb\u30a4\u3067\u8a55\u4fa1\u3057\u305f\u3068\u3053\u308d\u300154042-4\u3068\u540d\u4ed8\u3051\u3089\u308c\u305f\u6297\u4f53\u304c\u6700\u3082\u512a\u308c\u305f\u529b\u4fa1\u3092\u793a\u3057\u3001IC<sb>50<\/sub> = 9 ng\/mL\u3092\u5f97\u307e\u3057\u305f\u3001\u66f4\u306b\u3053\u306e\u6297\u4f53\u306f\u3001\u73fe\u5b58\u3059\u308bSARS-CoV-2\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u540c\u7b49\u306a\u4e2d\u548c\u80fd\u529b\u3092\u793a\u3057\u307e\u3057\u305f\u3002<br \/>\n54042-4 \u91cd\u9396\u306fSARS-CoV-2 RBD\u306e443\u2013447 \u6b8b\u57fa\u306b\u300154042-4 \u8efd\u9396\u306f498\u2013500 \u6b8b\u57fa\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3001cryo-EM \u3092\u7528\u3044\u305f\u69cb\u9020\u89e3\u6790\u304b\u3089\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/54042-4_antibody-_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/54042-4_antibody-_SARS-CoV-2-300x164.png\" alt=\"\" width=\"300\" height=\"164\" class=\"alignnone size-medium wp-image-6319\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/54042-4_antibody-_SARS-CoV-2-300x164.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/54042-4_antibody-_SARS-CoV-2-600x328.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/10\/54042-4_antibody-_SARS-CoV-2.png 721w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vanderbilt University Medical Center, Nashville, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001LIBRA-seq \u6280\u8853\u3092\u7528\u3044\u3066\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u3053\u3068\u3067\u3001SARS-CoV-2\u306b\u5bfe\u3057\u3066\u529b\u4fa1\u3082\u9ad8\u304f\u5909\u7570<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e5%8a%9b%e4%be%a1%e3%82%82%e9%ab%98%e3%81%8f%e5%a4%89%e7%95%b0%e3%81%ab%e3%82%82%e5%bc%b7%e3%81%84sars-cov-2-spike%e6%8a%97%e4%bd%93%e3%81%8c%e3%82%b9%e3%82%af%e3%83%aa%e3%83%bc%e3%83%b3%e3%81%95\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-6317","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Vanderbilt University 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