{"id":6314,"date":"2021-10-01T07:52:58","date_gmt":"2021-09-30T22:52:58","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6314"},"modified":"2021-10-01T07:58:20","modified_gmt":"2021-09-30T22:58:20","slug":"antibody-dependent-enhancement-of-sars-cvov-2-infection-is-real","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/antibody-dependent-enhancement-of-sars-cvov-2-infection-is-real\/","title":{"rendered":"Antibody-Dependent Enhancement of SARS-CVoV-2 infection is real"},"content":{"rendered":"<p>A group from The Institute of Medical Science, The University of Tokyo, etc. has reported that Antibody-Dependent Enhancement of SARS-CVoV-2 infection to immune cells is real.<br \/>\n<a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01987-21\">https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01987-21<\/a><\/p>\n<p>Viruses infect cells mainly via specific receptors at the cell surface. Antibody-dependent enhancement (ADE) of infection is an alternative mechanism of infection for viruses to infect immune cells that is mediated by antibodies and IgG receptors (Fc\u03b3Rs). <\/p>\n<p>Authors generated BHK cells stably expressing human Fc\u03b3Rs (Fc\u03b3RIA, Fc\u03b3RIIA, or Fc\u03b3RIIIA) or human angiotensin-converting enzyme 2 (hACE2) (the entry receptor for SARS-CoV-2). Wild-type BHK cells lack human ACE2 expression and are not susceptible to SARS-CoV-2. <\/p>\n<p>BHK cells were infected with a firefly luciferase-expressing vesicular stomatitis virus (VSV) lacking the VSV-G gene and pseudotyped with SARS-CoV-2 spike (VSV-SARS2-S). Although BHK-hACE2 cells were susceptible to VSV-SARS2-S, the BHK-Fc\u03b3RIA, BHK-Fc\u03b3RIIA, and BHK-Fc\u03b3RIIIA cells were not susceptible due to the lack of hACE2. However, using convalescent-phase plasma from COVID-19 patients and incubated with VSV-SARS2-S, it was found that two types of Fc\u03b3Rs, Fc\u03b3RIIA and Fc\u03b3RIIIA, mediate ADE of SARS-CoV-2 infection in the presence of ACE2. <\/p>\n<p>It was also confirmed that SARS-CoV-2 infection is enhanced by convalescent-phase plasma in primary macrophages.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/ADE_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/ADE_SARS-CoV-2-300x165.png\" alt=\"\" width=\"300\" height=\"165\" class=\"alignnone size-medium wp-image-6305\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/ADE_SARS-CoV-2-300x165.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/ADE_SARS-CoV-2.png 562w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from The Institute of Medical Science, The University of Tokyo, etc. has reported that Antibody-Depend<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/antibody-dependent-enhancement-of-sars-cvov-2-infection-is-real\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-6314","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6314"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6314\/revisions"}],"predecessor-version":[{"id":6316,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6314\/revisions\/6316"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6314"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6314"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}