{"id":6290,"date":"2021-09-29T10:50:25","date_gmt":"2021-09-29T01:50:25","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6290"},"modified":"2021-09-29T10:56:11","modified_gmt":"2021-09-29T01:56:11","slug":"hpa-is-not-only-a-good-tool-as-cancer-marker-but-also-could-be-used-for-therapeutic-applications","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/hpa-is-not-only-a-good-tool-as-cancer-marker-but-also-could-be-used-for-therapeutic-applications\/","title":{"rendered":"HPA is not only a good tool as cancer marker, but also could be used for therapeutic applications"},"content":{"rendered":"<p>A group from Facult\u00e9 de Pharmacie, Universit\u00e9 Paul, Sabatier, Toulouse, France, etc has reported that Helix pomatia lectin (HPA) is not only a good tool as cancer marker, but could also be used for therapeutic applications.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8431231\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8431231\/<\/a><\/p>\n<p>Morniga G lectin and HPA lectin are know to have binding specificity to Tn-antigen. Authors demonstrated in the past that Morniga G can interact with Tn antigen present on Jurkat human leukemia, inducing tumor cell death but not death of Tn-negative healthy peripheral blood lymphocytes. However, very little information was known about the putative functional role of HPA-binding glycoproteins on tumor cells. <\/p>\n<p>In this paper, authors have demonstrated for the first time that HPA induces cell death in human Jurkat T-cell leukemia and mouse EL4 T-cell lymphoma. In the mouse, HPA is clearly more toxic than Morniga G for EL4 cells. In addition, HPA appears to be non-toxic for healthy lymphocytes, suggesting that HPA could be used for therapeutic applications.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/MorG-and-HPA_Leukemia.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/MorG-and-HPA_Leukemia-300x126.png\" alt=\"\" width=\"300\" height=\"126\" class=\"alignnone size-medium wp-image-6286\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/MorG-and-HPA_Leukemia-300x126.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/MorG-and-HPA_Leukemia-600x252.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/MorG-and-HPA_Leukemia-768x322.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/MorG-and-HPA_Leukemia.png 863w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Facult\u00e9 de Pharmacie, Universit\u00e9 Paul, Sabatier, Toulouse, France, etc has reported that Helix po<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/hpa-is-not-only-a-good-tool-as-cancer-marker-but-also-could-be-used-for-therapeutic-applications\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-6290","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6290","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6290"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6290\/revisions"}],"predecessor-version":[{"id":6295,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6290\/revisions\/6295"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6290"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6290"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}