{"id":6143,"date":"2021-09-16T08:45:18","date_gmt":"2021-09-15T23:45:18","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6143"},"modified":"2021-09-16T09:05:55","modified_gmt":"2021-09-16T00:05:55","slug":"clec4g-cd209%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%8c%e5%bc%b7%e3%81%8fsars-cov-2%e3%81%ab%e7%b5%90%e5%90%88%e3%81%97%e3%80%81%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e5%ae%b3%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/clec4g-cd209%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%8c%e5%bc%b7%e3%81%8fsars-cov-2%e3%81%ab%e7%b5%90%e5%90%88%e3%81%97%e3%80%81%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e5%ae%b3%e3%81%99%e3%82%8b\/","title":{"rendered":"CLEC4G, CD209\uff08C-\u578b\u30ec\u30af\u30c1\u30f3\uff09\u304c\u5f37\u304fSARS-CoV-2\u306b\u7d50\u5408\u3057\u3001\u611f\u67d3\u3092\u963b\u5bb3\u3059\u308b"},"content":{"rendered":"<p>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Austria\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001CLEC4G\u3068CD209c\uff08C-\u578b\u30ec\u30af\u30c1\u30f3\uff09\u304cSARS-CoV-2\u306e\u611f\u67d3\u3092\u963b\u5bb3\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8420505\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8420505\/<\/a><\/p>\n<p>168\u7a2e\u985e\u306e\u65e2\u77e5\u306e\u30de\u30a6\u30b9\u306eC-\u578b\u30ec\u30af\u30c1\u30f3\u3001\u30ac\u30ec\u30af\u30c1\u30f3\u3084\u30b7\u30b0\u30ec\u30c3\u30af\u306e\u7cd6\u9396\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u304b\u3089\u3001HEK293F\u3092\u5bbf\u4e3b\u7d30\u80de\u3068\u3057\u3066143\u7a2e\u985e\u306e\u305d\u308c\u3089\u7cd6\u9396\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u3068IgG2a-Fc\u3068\u306e\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u306f\u6050\u3089\u304f\u4e16\u754c\u3067\u3082\u6700\u5927\u306e\u3082\u306e\u3067\u3042\u308a\u3001\u672c\u7814\u7a76\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30ec\u30af\u30c1\u30f3\u3068\u3044\u3046\u540d\u3067\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>SARS-CoV-2 Spike \u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u7cd6\u9396\u306f\u3001\u30aa\u30ea\u30b4\u30de\u30f3\u30ce\u30fc\u30b9\u304b\u3089\u4fee\u98fe\u306e\u9032\u3093\u3060\u591a\u5206\u5c90\u306e\u8907\u5408\u578bN-\u578b\u7cd6\u9396\u307e\u3067\u3001\u4fee\u98fe\u4f4d\u7f6e\u306b\u4f9d\u5b58\u3057\u305f\u5f62\u3067\u5e83\u304f\u5206\u5e03\u3057\u3066\u3044\u307e\u3059\u3002RBD\u306b\u306f\u3001N331\u3068N343 \u306bN-\u578b\u7cd6\u9396\u304c\u4fee\u98fe\u3055\u308c\u3066\u304a\u308a\u3001\u30b7\u30a2\u30eb\u9178\u3084\u30d5\u30b3\u30fc\u30b9\u4fee\u98fe\u3092\u542b\u3093\u3060\u7cd6\u9396\u304c\u4ed8\u52a0\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u72b6\u614b\u306f\u3001SARS-CoV-2 Spike\u3092\u5168\u9577\u3067\u767a\u73fe\u3055\u305b\u305f\u5834\u5408\u3068\u3001ACE2\u306b\u7d50\u5408\u3059\u308b\u6700\u5c0f\u30c9\u30e1\u30a4\u30f3\u3068\u3057\u3066\u306eRBD\u306e\u307f\u3092\u767a\u73fe\u3055\u305b\u305f\u5834\u5408\u3067\u306f\u7570\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u5f93\u3063\u3066\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u3092\u7814\u7a76\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u5168\u9577\u306eSpike\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3042\u308b\u3053\u3068\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u66f4\u306b\u3053\u306e\u3053\u3068\u306f\u3001\u7cd6\u9396\u4fee\u98fe\u306e\u9055\u3044\u304c\u3001\u514d\u75ab\u6d3b\u6027\u3084\u91cd\u75c7\u5316\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/p>\n<p>\u3068\u3082\u3042\u308c\u3001\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001\u3075\u305f\u3064\u306e\u30ec\u30af\u30c1\u30f3\u3001CLEC4G \u3068 CD209c\u3001\u304c\u5f37\u304fSARS-CoV-2 Spike\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3001\u305d\u306e\u7d50\u5408\u72b6\u614b\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u3066AFM\u3067\u53ef\u8996\u5316\u3059\u308b\u3053\u3068\u306b\u3082\u6210\u529f\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u5f97\u3089\u308c\u305f3D\u30e2\u30c7\u30eb\u306f\u3001\u3053\u308c\u3089\u30ec\u30af\u30c1\u30f3\u304cRBD-ACE2\u7d50\u5408\u754c\u9762\u5185\u306e\u7cd6\u9396\u306b\u7d50\u5408\u3057\u3066\u304a\u308a\u3001Spike\u306e\u5bbf\u4e3b\u7d30\u80de\u8868\u9762\u3078\u306e\u7d50\u5408\u306b\u5e72\u6e09\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u3001CLEC4G\u3068CD209c\u304cSRS-CoV-2\u306e\u611f\u67d3\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u3001VeroE6\u53ca\u3073Calu3\u7d30\u80de\u3092\u7528\u3044\u3066\u793a\u3055\u308c\u307e\u3057\u305f\u3002 <\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Infectivity-with-CLRC4G-and-CD209c.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Infectivity-with-CLRC4G-and-CD209c-159x300.png\" alt=\"\" width=\"159\" height=\"300\" class=\"alignnone size-medium wp-image-6145\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Infectivity-with-CLRC4G-and-CD209c-159x300.png 159w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Infectivity-with-CLRC4G-and-CD209c.png 391w\" sizes=\"auto, (max-width: 159px) 100vw, 159px\" \/><\/a> \u30a6\u30a4\u30eb\u30b9\u306e\u611f\u67d3\u91cf\u306f\u3001SARS-CoV-2\u611f\u67d315\u6642\u9593\u5f8c\u306bqRT-PCR\u306b\u3066\u30a6\u30a4\u30eb\u30b9\u306eRNA\u91cf\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u884c\u308f\u308c\u3001mock\uff08SARS-CoV-2\u306e\u307f\u3092\u4e0e\u3048\u305f\u5834\u5408\uff09\u306b\u6bd4\u8f03\u3057\u305f\u5f62\u3067\u306e\u500d\u7387\u5909\u5316\u306b\u3088\u3063\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Austria\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001CLEC4G\u3068CD209c\uff08<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/clec4g-cd209%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%8c%e5%bc%b7%e3%81%8fsars-cov-2%e3%81%ab%e7%b5%90%e5%90%88%e3%81%97%e3%80%81%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e5%ae%b3%e3%81%99%e3%82%8b\/\" 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