{"id":6131,"date":"2021-09-14T11:29:46","date_gmt":"2021-09-14T02:29:46","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6131"},"modified":"2021-09-14T11:29:46","modified_gmt":"2021-09-14T02:29:46","slug":"%e3%83%97%e3%83%ad%e3%83%99%e3%83%8d%e3%82%b7%e3%83%89%e3%81%8ccovid-19%e3%81%ae%e6%b2%bb%e7%99%82%e8%96%ac%e5%80%99%e8%a3%9c%e3%81%a7%e3%81%82%e3%82%8b%ef%bc%9aota3%e3%82%92%e9%98%bb%e5%ae%b3","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%83%97%e3%83%ad%e3%83%99%e3%83%8d%e3%82%b7%e3%83%89%e3%81%8ccovid-19%e3%81%ae%e6%b2%bb%e7%99%82%e8%96%ac%e5%80%99%e8%a3%9c%e3%81%a7%e3%81%82%e3%82%8b%ef%bc%9aota3%e3%82%92%e9%98%bb%e5%ae%b3\/","title":{"rendered":"\u30d7\u30ed\u30d9\u30cd\u30b7\u30c9\u304cCOVID-19\u306e\u6cbb\u7642\u85ac\u5019\u88dc\u3067\u3042\u308b\uff1aOTA3\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067SARS-CoV-2\u306e\u8907\u88fd\u3092\u963b\u5bb3\u3059\u308b"},"content":{"rendered":"<p>Department of Infectious Diseases, University of Georgia, Athens, GA, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d7\u30ed\u30da\u30cd\u30b7\u30c9\uff08\u75db\u98a8\u6cbb\u7642\u85ac\uff09\u304cCOVID-19\u306e\u512a\u308c\u305f\u6cbb\u7642\u85ac\u306b\u306a\u308a\u5f97\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-97658-w\">https:\/\/www.nature.com\/articles\/s41598-021-97658-w<\/a><\/p>\n<p>\u6709\u6a5f\u9670\u30a4\u30aa\u30f3\u8f38\u9001\u4f533\uff08OAT3\uff09\u304c\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u30db\u30b9\u30c8\u5074\u306e\u907a\u4f1d\u5b50\u306e\u3072\u3068\u3064\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002OAT3 \u306f\u3001\u814e\u81d3\u3001\u8108\u7d61\u53e2\u3001\u8840\u7ba1\u5e8a\u3001\u80ba\u3092\u542b\u3080\u4ed6\u306e\u672b\u68a2\u5668\u5b98\u306b\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u5c3f\u9178\u304a\u3088\u3073\u4ed6\u306e\u57fa\u8cea\u304a\u3088\u3073\u7279\u5b9a\u306e\u6297\u751f\u7269\u8cea\u3092\u542b\u3080\u5185\u56e0\u6027\u6709\u6a5f\u30a2\u30cb\u30aa\u30f3\u306e\u819c\u8cab\u901a\u8f38\u9001\u3092\u4ef2\u4ecb\u3057\u307e\u3059\u3002\u30d7\u30ed\u30da\u30cd\u30b7\u30c9\u30aa\u306f\u3001OTA3\u3092\u963b\u5bb3\u3059\u308b\u6cbb\u7642\u85ac\u3068\u3057\u3066\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u75db\u98a8\u6cbb\u7642\u85ac\u3068\u3057\u3066\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30d7\u30ed\u30da\u30b7\u30c9\u306f\u3001\u85ac\u7269\u52d5\u614b\u7684\u306b\u3082\u597d\u307e\u3057\u304f\u3001\u81e8\u5e8a\u7684\u306a\u89b3\u70b9\u3067\u3082\u5b89\u5168\u6027\u304c\u9ad8\u304f\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u3068\u3057\u3066\u8ee2\u7528\u3059\u308b\u5834\u5408\u306e\u975e\u5e38\u306b\u826f\u3044\u5019\u88dc\u3068\u306a\u308a\u3048\u307e\u3059\u3002<\/p>\n<p>Probenecid treatment reduced SARS-CoV-2 replication by 90% in \u30d2\u30c8\u6c17\u7ba1\u652f\u4e0a\u76ae\uff08NHBE\uff09\u7d30\u80de\u3092\u7528\u3044\u305fin vitro\u5b9f\u9a13\u3067\u3001\u30d7\u30ed\u30da\u30cd\u30b7\u30c9\u306fSARS-CoV-2\u306e\u8907\u88fd\u309290\uff05\u4f4e\u6e1b\u3057\u3001IC<sub>50<\/sub>\u306e\u5024\u306f\u30010.0013 \u03bcM \u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30d7\u30ed\u30da\u30cd\u30b7\u30c9\u306f\u3001SARS-CoV-2\u306e\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u3082\u6709\u52b9\u3067\u3042\u308d\u3046\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3068\u3044\u3046\u306e\u306f\u3001OTA3\u306e\u3088\u3046\u306a\u5bbf\u4e3b\u5074\u306e\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u306b\u95a2\u4fc2\u3059\u308b\u30d7\u30ed\u30bb\u30b9\u3092\u963b\u5bb3\u3059\u308b\u3082\u306e\u3060\u304b\u3089\u3067\u3059\u3002\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u3092\u963b\u5bb3\u3059\u308b\u6f5c\u5728\u7684\u306a\u5bbf\u4e3b\u5074\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u4e2d\u3067\u3001OTA3\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3082\u30d2\u30c8\u306f\u5065\u5eb7\u3067\u3042\u308a\u3001OTA3\u306e\u963b\u5bb3\u304c\u30d2\u30c8\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u304f\u3001\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u963b\u5bb3\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u30c9\u30fc\u30ba\u3067\u3082\u5b89\u5168\u306b\u8a31\u5bb9\u3055\u308c\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Probenecid-inhibits-SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Probenecid-inhibits-SARS-CoV-2-300x192.png\" alt=\"\" width=\"300\" height=\"192\" class=\"alignnone size-medium wp-image-6133\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Probenecid-inhibits-SARS-CoV-2-300x192.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Probenecid-inhibits-SARS-CoV-2-600x384.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/Probenecid-inhibits-SARS-CoV-2.png 665w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Infectious Diseases, University of Georgia, Athens, GA, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d7\u30ed\u30da\u30cd\u30b7\u30c9\uff08\u75db\u98a8\u6cbb\u7642\u85ac\uff09\u304cCOVID-19\u306e\u512a\u308c\u305f\u6cbb\u7642\u85ac<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%83%97%e3%83%ad%e3%83%99%e3%83%8d%e3%82%b7%e3%83%89%e3%81%8ccovid-19%e3%81%ae%e6%b2%bb%e7%99%82%e8%96%ac%e5%80%99%e8%a3%9c%e3%81%a7%e3%81%82%e3%82%8b%ef%bc%9aota3%e3%82%92%e9%98%bb%e5%ae%b3\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-6131","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Department of Infectious 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