{"id":6073,"date":"2021-09-12T09:56:07","date_gmt":"2021-09-12T00:56:07","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6073"},"modified":"2021-09-13T09:01:25","modified_gmt":"2021-09-13T00:01:25","slug":"covid-19%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6%e3%81%af%e3%83%aa%e3%83%b3%e3%83%91%e7%90%83%e6%b8%9b%e5%b0%91%e7%97%87%e3%81%8c%e8%a6%8b%e3%82%89%e3%82%8c%e3%82%8b%e3%81%8c%e3%80%81%e4%bd%95%e6%95%85","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/covid-19%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6%e3%81%af%e3%83%aa%e3%83%b3%e3%83%91%e7%90%83%e6%b8%9b%e5%b0%91%e7%97%87%e3%81%8c%e8%a6%8b%e3%82%89%e3%82%8c%e3%82%8b%e3%81%8c%e3%80%81%e4%bd%95%e6%95%85\/","title":{"rendered":"COVID-19\u306b\u304a\u3044\u3066\u306f\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u75c7\u304c\u898b\u3089\u308c\u308b\u304c\u3001\u4f55\u6545\u304bTIM-3 CD4<sup>+<\/sup>\u306f\u5897\u52a0\u3057\u3066\u3044\u308b"},"content":{"rendered":"<p>University of Medical Sciences, Babol, Iran\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306e\u91cd\u75c7\u304b\u3089\u4e2d\u75c7\u306e\u60a3\u8005\u306b\u304a\u3051\u308bCD4<sup>+<\/sup> T \u7d30\u80de\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u306b\u898b\u3089\u308c\u308b\u8208\u5473\u6df1\u3044\u73fe\u8c61\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.526\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.526<\/a><\/p>\n<p>COVID-19\u306b\u304a\u3051\u308b\u91cd\u75c7\u304b\u3089\u4e2d\u75c7\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u3001\u5065\u5e38\u8005\u306b\u6bd4\u8f03\u3057\u3066\u3001TIM-3 \u304c CD4<sup>+<\/sup> T \u7d30\u80de\u306b\u304a\u3044\u3066\u9855\u8457\u306b\u904e\u5270\u767a\u73fe\u3057\u3066\u304a\u308a\u3001CD4<sup>+<\/sup> TIM-3<sup>+<\/sup> CD39<sup>+<\/sup> \u30ea\u30f3\u30d1\u7403\u3082\u91cd\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u5065\u5e38\u8005\u3088\u308a\u3082\u9855\u8457\u306b\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>COVID-19\u306e\u91cd\u75c7\u304b\u3089\u4e2d\u75c7\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u3001\u5065\u5e38\u8005\u306b\u6bd4\u3079\u3066\u30ea\u30f3\u30d1\u7403\u5168\u4f53\u304c\u9855\u8457\u306b\u6e1b\u5c11\u3057\u3001\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u75c7\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u591a\u304f\u306eT \u7d30\u80de\u304c\u8840\u7ba1\u304b\u3089\u80ba\u7d44\u7e54\u306e\u9593\u8cea\u306b\u4fb5\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u672b\u68a2\u8840\u306eT \u7d30\u80de\u6e1b\u5c11\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u304b\u3089\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001CD4<sup>+<\/sup> T \u7d30\u80de\u306b\u3064\u3044\u3066\u306f\u3001\u3059\u3079\u3066\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u5927\u304d\u306a\u9055\u3044\u304c\u898b\u3089\u308c\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u305d\u308c\u3068\u5bfe\u7167\u7684\u306b\u3001\u5168\u4f53\u7684\u306a\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u75c7\u4ee5\u5916\u306b\u3001CD8<sup>+<\/sup> T \u7d30\u80de\u304cCOVID-19\u91cd\u75c7\u60a3\u8005\u3067\u5065\u5e38\u8005\u306b\u6bd4\u3079\u3066\u9855\u8457\u306b\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3082COVID-19\u306e\u5927\u304d\u306a\u7279\u5fb4\u3067\u3059\u3002<\/p>\n<p>TIM-3 \u306f\u3001\u3053\u306e\u3088\u3046\u306a\u75b2\u5f0a\u3057\u305fT \u7d30\u80de\u306e\u30de\u30fc\u30ab\u30fc\u306e\u4e00\u3064\u3067\u3042\u308a\u3001Galectin-9 (Gal-9) \u304cTIM-3\u306e\u30ea\u30ac\u30f3\u30c9\u306e\u3072\u3068\u3064\u3067\u3042\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001TIM-3\/Gal-9 \u306e\u76f8\u4e92\u4f5c\u7528\u304cTh1 \u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001CD39\u306f\u3001\u7d30\u80de\u5916\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff08ATP\uff09\u306e\u52a0\u6c34\u5206\u89e3\u9175\u7d20\u306b\u3088\u3063\u3066\u7d30\u80de\u5916\u30a2\u30c7\u30ce\u30b7\u30f3\u3092\u751f\u6210\u3059\u308b\u5916\u90e8\u9175\u7d20\u3067\u3042\u308a\u3001\u640d\u50b7\u3057\u305f\u7d30\u80de\u306f\u7d30\u80de\u5916ATP\u3092\u5206\u6ccc\u3057\u3001\u708e\u75c7\u8a98\u767a\u6027\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u4f55\u6545\u3001\u3053\u306e\u3088\u3046\u306aCD4<sup>+<\/sup> T \u7d30\u80de\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u304cCOVID-19\u3067\u4e0a\u6607\u3059\u308b\u306e\u304b\uff1f\u306b\u3064\u3044\u3066\u306f\u975e\u5e38\u306b\u8208\u5473\u6df1\u304f\u3001\u6cbb\u7642\u306b\u304a\u3044\u3066\u306f\u3001\u3053\u308c\u3089T \u7d30\u80de\u3092\u53b3\u5bc6\u306b\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u3068\u3066\u3082\u5927\u5207\u3067\u3042\u308b\u3088\u3046\u306b\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/TIM-3-on-CD4-T-cell_COVID-19.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/TIM-3-on-CD4-T-cell_COVID-19-300x164.png\" alt=\"\" width=\"300\" height=\"164\" class=\"alignnone size-medium wp-image-6077\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/TIM-3-on-CD4-T-cell_COVID-19-300x164.png 300w, 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