{"id":6058,"date":"2021-09-09T10:06:54","date_gmt":"2021-09-09T01:06:54","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=6058"},"modified":"2021-09-09T10:10:36","modified_gmt":"2021-09-09T01:10:36","slug":"a-novel-sars-cov-2-virus-like-nanoparticle-vaccine-induced-high-titer-neutralizing-antibodies","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-novel-sars-cov-2-virus-like-nanoparticle-vaccine-induced-high-titer-neutralizing-antibodies\/","title":{"rendered":"A novel SARS-CoV-2 virus-like nanoparticle vaccine induced high-titer neutralizing antibodies"},"content":{"rendered":"<p>A group from Center for Coronavirus Research, University of Minnesota, Saint Paul, USA, etc. has developed a novel SARS-CoV-2 virus-like nanoparticle vaccine.<br \/>\n<a href=\"https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1009897\">https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1009897<\/a><\/p>\n<p>A lumazine synthase nanoparticle protein containing a N-terminal protein A tag was used as a structural scaffold of virus-like nanoparticle (VLP) vaccine. The size of nanoparticle was about 15nm in diameter. Then, a complex of the VLP nanoparticle and SARS-CoV-2 RBD (containing a C-terminal Fc tag) was formed as the VLP vaccine. This design of the VLP vaccine allowed 60 copies of Fc-tagged dimeric SARS-CoV-2 RBD, corresponding to 120 copies of SARS-CoV-2 RBD.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/novel_SARS-CoV-2_RBD_nanoparticle_vaccine.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/novel_SARS-CoV-2_RBD_nanoparticle_vaccine-300x166.png\" alt=\"\" width=\"300\" height=\"166\" class=\"alignnone size-medium wp-image-6050\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/novel_SARS-CoV-2_RBD_nanoparticle_vaccine-300x166.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/novel_SARS-CoV-2_RBD_nanoparticle_vaccine-600x333.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/novel_SARS-CoV-2_RBD_nanoparticle_vaccine-768x426.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/09\/novel_SARS-CoV-2_RBD_nanoparticle_vaccine.png 801w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Authors has reported that this VLP vaccine induced high-titer neutralizing antibody responses in mice that lasted >2 months and potently inhibited SARS-CoV-2, SARS-CoV-1, and their variants(\u03b1, \u03b2, and \u03b3 variants).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Center for Coronavirus Research, University of Minnesota, Saint Paul, USA, etc. has developed a n<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-novel-sars-cov-2-virus-like-nanoparticle-vaccine-induced-high-titer-neutralizing-antibodies\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-6058","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=6058"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6058\/revisions"}],"predecessor-version":[{"id":6059,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/6058\/revisions\/6059"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=6058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=6058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=6058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}