{"id":5919,"date":"2021-08-26T09:10:39","date_gmt":"2021-08-26T00:10:39","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5919"},"modified":"2021-08-26T12:45:03","modified_gmt":"2021-08-26T03:45:03","slug":"%e5%bc%b7%e3%81%84%e5%85%8d%e7%96%ab%e5%9c%a7%e5%8a%9b%e4%b8%8b%e3%81%a7%e3%80%8180%e6%97%a5%e9%96%93%e3%81%a7sars-cov-2%e3%81%afntd%e3%82%84rbd%e3%81%ab%e5%a4%89%e7%95%b0%e3%82%92%e4%bd%9c%e3%81%a3","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e5%bc%b7%e3%81%84%e5%85%8d%e7%96%ab%e5%9c%a7%e5%8a%9b%e4%b8%8b%e3%81%a7%e3%80%8180%e6%97%a5%e9%96%93%e3%81%a7sars-cov-2%e3%81%afntd%e3%82%84rbd%e3%81%ab%e5%a4%89%e7%95%b0%e3%82%92%e4%bd%9c%e3%81%a3\/","title":{"rendered":"\u5f37\u3044\u514d\u75ab\u5727\u529b\u4e0b\u3067\u300180\u65e5\u9593\u3067SARS-CoV-2\u306fNTD\u3084RBD\u306b\u5909\u7570\u3092\u4f5c\u3063\u3066\u4e2d\u548c\u6297\u4f53\u304b\u3089\u514d\u75ab\u3092\u9003\u308c\u305f"},"content":{"rendered":"<p>Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, Siena, Italy\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5f37\u3044\u514d\u75ab\u5727\u529b\u4e0b\u3067\u3001SARS-CoV-2\u306f\u3001\u5909\u7570\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u300180\u65e5\u9593\u306b\u3066\u56de\u5fa9\u671f\u60a3\u8005\u306e\u4e2d\u548c\u6297\u4f53\u304b\u3089\u9003\u308c\u3066\u3057\u307e\u3063\u305f\u3001\u3068\u3044\u3046\u5831\u544a\u3092\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.pnas.org\/content\/118\/36\/e2103154118.long\">https:\/\/www.pnas.org\/content\/118\/36\/e2103154118.long<\/a><\/p>\n<p>\u30ef\u30af\u30c1\u30f3\u958b\u767a\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u554f\u984c\u306f\u3001\u56de\u5fa9\u671f\u60a3\u8005\u3084\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6e08\u307f\u8005\u306e\u6297\u4f53\u514d\u75ab\u4e0b\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u5b8c\u5168\u306b\u514d\u75ab\u3092\u9003\u308c\u308b\u3088\u3046\u306b\u9032\u5316\u3067\u304d\u308b\u304b\u5426\u304b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u554f\u984c\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u56de\u5fa9\u671f\u60a3\u8005\u306e\u8840\u6f3f\u3068SARS-CoV-2 wild-type (WT) \u3068\u306e\u6df7\u5408\u7269\u3092 Vero E6 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\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306b\u5bfe\u3057\u3066\u6700\u3082\u5f37\u3044\u7d50\u5408\u529b\u3092\u793a\u3057\u3001RBD\u306b\u5bfe\u3057\u3066\u6700\u3082\u5f37\u3044\u529b\u4fa1\uff081\/1,280\uff09\u3092\u793a\u3057\u307e\u3057\u305f\u3002.<\/p>\n<p>\u3053\u306e\u8840\u6f3f\u306f\u30017\u7d99\u4ee3\u306b\u6e21\u3063\u3066\u30a6\u30a4\u30eb\u30b9\u3092\u5b8c\u5168\u306b\u4e2d\u548c\u5316\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u30017\u7d99\u4ee345\u65e5\u5f8c\u306b\u306f\u3001NTD\u306eN3\u30eb\u30fc\u30d7\u5185\u306bF140\u6b20\u640d\u304c\u767a\u751f\u3057\u305f\u3053\u3068\u3067\u30d6\u30ec\u30fc\u30af\u30b9\u30eb\u30fc\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\u300211\u7d99\u4ee373\u65e5\u76ee\u306b\u306f\u3001RBD\u306bE484K\u5909\u7570\u304c\u767a\u751f\u3057\u300112\u7d99\u4ee380\u65e5\u306b\u306fNTD\u306bN5\u30eb\u30fc\u30d7\u304c\u633f\u5165\u3055\u308c\u65b0\u3057\u3044\u7cd6\u9396\u304c\u4ed8\u52a0\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u4e8b\u306b\u3088\u3063\u3066\u3001SARS-CoV-2\u306fPT188\u8840\u6f3f\u306e\u4e2d\u548c\u80fd\u529b\u304b\u3089\u5b8c\u5168\u306b\u9003\u308c\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/PT188_Mutation.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/PT188_Mutation-300x138.png\" alt=\"\" width=\"300\" height=\"138\" class=\"alignnone size-medium wp-image-5938\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/PT188_Mutation-300x138.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/PT188_Mutation-600x277.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/PT188_Mutation-768x354.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/PT188_Mutation.png 872w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>NTD\u5185\u3084NTD\u30eb\u30fc\u30d7\u8fd1\u508d\u306b\u898b\u3089\u308c\u305f\u5909\u7570\u3084\u6b20\u640d\u306f\u3001\u5b9f\u969b\u306b\u6700\u8fd1\u306eSARS-CoV-2\u306e\u5909\u7570\u682a\uff08\u30a2\u30eb\u30d5\u30a1\u3001\u30d9\u30fc\u30bf\u3001\u30ac\u30f3\u30de\u5909\u7570\u682a\uff09\u3067\u3082\u898b\u3089\u308c\u3066\u304a\u308a\u3001\u7cd6\u9396\u306e\u4ed8\u52a0\u306f\u30a6\u30a4\u30eb\u30b9\uff08\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3084HIV 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href=\"https:\/\/www.emukk.com\/WP\/%e5%bc%b7%e3%81%84%e5%85%8d%e7%96%ab%e5%9c%a7%e5%8a%9b%e4%b8%8b%e3%81%a7%e3%80%8180%e6%97%a5%e9%96%93%e3%81%a7sars-cov-2%e3%81%afntd%e3%82%84rbd%e3%81%ab%e5%a4%89%e7%95%b0%e3%82%92%e4%bd%9c%e3%81%a3\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-5919","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Monoclonal Antibody Discovery Lab, Fondazione Toscana L\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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