{"id":5912,"date":"2021-08-25T13:52:11","date_gmt":"2021-08-25T04:52:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5912"},"modified":"2021-08-25T13:53:28","modified_gmt":"2021-08-25T04:53:28","slug":"incidence-rates-of-guillian-barre-syndrome-gbs-in-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/incidence-rates-of-guillian-barre-syndrome-gbs-in-covid-19\/","title":{"rendered":"Incidence rates of Guillian-Barre syndrome (GBS) in COVID-19"},"content":{"rendered":"

A group from Emergency Department, San Carlos Clinical Hospital, Complutense University, Madrid, Spain, etc. has reported on incidence rates of Guillian-Barre syndrome (GBS) in COVID-19 comparing with non-COVID-19.
\nhttps:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.25987<\/a><\/p>\n

The standardized incidences of GBS were 9.44 per 100,000 COVID inhabitants (95% CI = 7.30\u201312.0), and 0.69 per 100,000 non-COVID inhabitants (95% CI = 0.56\u20130.84). The OR for the standardized incidence of COVID with respect to non-COVID patients was 13.5 (95% CI = 9.88\u201318.4). <\/p>\n

GBS is an autoimmune disorder of the peripheral nervous system which is usually triggered by virus\/pathogen infections.
\nThe onset mechanism of GBS is considered as follows.
\nAntibodies targeting glycolipid-like antigens on virus\/pathogen eventually form membrane attack complexes through activated complement cascades triggered by the cross-reactive attachment of the same antibodies onto GM1 on axonal neurons, and cause damages on peripheral nerve system.<\/p>\n

\"\"<\/a>
\nA figure cited from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8196284\/<\/a><\/p>\n

Blog admin is not sure what glycan structure on SARS-CoV-2 Spike induces a cross reactive antibody to GM1, but Gal\u03b21-3GalNAc would be more likely comparing with others.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Emergency Department, San Carlos Clinical Hospital, Complutense University, Madrid, Spain, etc. h<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-5912","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t