{"id":5884,"date":"2021-08-24T08:16:17","date_gmt":"2021-08-23T23:16:17","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5884"},"modified":"2021-08-25T06:35:26","modified_gmt":"2021-08-24T21:35:26","slug":"%e8%82%ba%e6%84%9f%e6%9f%93%e7%97%87%e3%82%92%e5%bc%95%e3%81%8d%e8%b5%b7%e3%81%93%e3%81%99%e3%82%b9%e3%82%b1%e3%83%89%e3%82%b9%e3%83%9d%e3%83%aa%e3%82%a6%e3%83%a0%e5%b1%9e%e3%81%af%e3%80%81%e3%83%95","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e8%82%ba%e6%84%9f%e6%9f%93%e7%97%87%e3%82%92%e5%bc%95%e3%81%8d%e8%b5%b7%e3%81%93%e3%81%99%e3%82%b9%e3%82%b1%e3%83%89%e3%82%b9%e3%83%9d%e3%83%aa%e3%82%a6%e3%83%a0%e5%b1%9e%e3%81%af%e3%80%81%e3%83%95\/","title":{"rendered":"\u80ba\u611f\u67d3\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u30b9\u30b1\u30c9\u30b9\u30dd\u30ea\u30a6\u30e0\u5c5e\u306f\u3001\u30d5\u30b3\u30fc\u30b9\u7279\u7570\u7684\u306aSapL1\u30ec\u30af\u30c1\u30f3\u3092\u6301\u3061\u3001\u80ba\u4e0a\u76ae\u7d30\u80de\u306b\u7d50\u5408\u3059\u308b"},"content":{"rendered":"<p>Univ. Grenoble Alpes, France\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u771f\u83cc\u3067\u3042\u308b\u30b9\u30b1\u30c9\u30b9\u30dd\u30ea\u30a6\u30e0\u30fb\u30a2\u30d4\u30aa\u30b9\u30da\u30eb\u30e0\u30e0\u304c\u6301\u3064\u30ec\u30af\u30c1\u30f3\u3001Scedosporium apiospermum Lectin 1 (SapL1)\u3001\u306e\u7cd6\u9396\u7d50\u5408\u7279\u7570\u6027\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-95008-4\">https:\/\/www.nature.com\/articles\/s41598-021-95008-4<\/a><\/p>\n<p>\u30b9\u30b1\u30c9\u30b9\u30dd\u30ea\u30a6\u30e0\u30fb\u30a2\u30d4\u30aa\u30b9\u30da\u30eb\u30e0\u30e0\u306f\u3001\u30d2\u30c8\u306e\u80ba\u611f\u67d3\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u65e5\u548c\u898b\u771f\u83cc\u75c5\u539f\u83cc\u3067\u3042\u308a\u3001\u571f\u58cc\u306b\u5e83\u304f\u5206\u5e03\u3057\u3066\u3044\u307e\u3059\u3002\u5bbf\u4e3b\u3068\u75c5\u539f\u83cc\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u3057\u3070\u3057\u3070\u30ec\u30af\u30c1\u30f3\u304c\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u7d50\u5408\u3092\u963b\u5bb3\u3059\u308b\u305f\u3081\u306e\u7cd6\u9396\u69d8\u5206\u5b50\u306e\u958b\u767a\u306e\u305f\u3081\u306e\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8457\u8005\u3089\u306e\u3053\u306e\u5831\u544a\u306f\u3001\u3053\u306eSapL1\u3068\u540d\u4ed8\u3051\u3089\u308c\u305f\u30ec\u30af\u30c1\u30f3\u306e\u7cd6\u9396\u7d50\u5408\u7279\u7570\u6027\u3089\u306b\u3064\u3044\u3066\u521d\u3081\u3066\u306e\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p>\u80ba\u4e0a\u76ae\u7d30\u80de\u8868\u9762\u3078\u306eSapL1\u306e\u7d50\u5408\u30ea\u30ac\u30f3\u30c9\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001585\u7a2e\u985e\u306e\u7cd6\u9396\u3092\u56fa\u5b9a\u5316\u3057\u305fCFG\u306e\u7cd6\u9396\u30a2\u30ec\u30a4Ver5.4\u304c\u4f7f\u308f\u308c\u307e\u3057\u305f\u3002SapL1\u3092FITC\u306b\u3066\u30e9\u30d9\u30ea\u30f3\u30b0\u3057\u3001\u3075\u305f\u3064\u306e\u6fc3\u5ea6\uff085 \u3068 50 \u03bcg\/mL\uff09\u3067\u30a2\u30d7\u30e9\u30a4\u3057\u307e\u3057\u305f\u3002SapL1 \u306f\u3001\u30d5\u30b3\u30b7\u30eb\u5316\u3055\u308c\u305f\u7cd6\u9396\u3092\u8a8d\u8b58\u3059\u308b\u3088\u3046\u3067\u3042\u308a\u3001\u30d5\u30b3\u30fc\u30b9\u306e\u4fee\u98fe\u914d\u4f4d\u306b\u306f\u305d\u308c\u307b\u3069\u5927\u304d\u304f\u5f71\u97ff\u3055\u308c\u307e\u305b\u3093\u3002\u03b11,2 \u304a\u3088\u3073 \u03b11,3\/4 \u914d\u4f4d\u306e\u30d5\u30b3\u30fc\u30b9\u3067\u9ad8\u3044\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u793a\u3057\u3001core fucose\uff08\u03b11,6 \u914d\u4f4d\uff09\u3067\u306f\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u304c\u4e0b\u304c\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u6700\u3082\u5f31\u3044\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u793a\u3059\u306e\u306f\u3001\u591a\u5206\u5c90\u306e\u30d5\u30b3\u30b7\u30eb\u5316\u7cd6\u9396\u3067\u3059\u3002<\/p>\n<p>\u8840\u6db2\u578b\u306b\u95a2\u4fc2\u3059\u308b\u7cd6\u9396\u306b\u95a2\u3057\u3066\u3001SapL1 \u306f\u3001H-\u6297\u539f\uff08Fuc\u03b11-2Gal\u03b21-4GlcNAc\u03b2\uff09\u306b\u5f37\u304f\u7d50\u5408\u3057\u3001Lewis a\uff08Gal\u03b21-3(Fuc\u03b11-4)GlcNAc\u03b2\uff09\u305d\u3057\u3066 Lewis X\uff08Gal\u03b21-4(Fuc\u03b11-3)GlcNAc\u03b2\uff09\u306e\u9806\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8a8d\u8b58\u3055\u308c\u305f\u5206\u5c90\u578b\u7cd6\u9396\u306b\u306fcore fucose\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3075\u305f\u3064\u306e\u30d5\u30b3\u30fc\u30b9\u30e6\u30cb\u30c3\u30c8\u3092\u542b\u3080\u69cb\u9020\u3001\u4f8b\u3048\u3070Lewis b \u3084 \u30d5\u30b3\u30b7\u30eb\u5316\u30dd\u30ea\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u3001\u306f\u826f\u304f\u8a8d\u8b58\u3055\u308c\u307e\u3057\u305f\u3002B\u6297\u539f\u3084A\u6297\u539f\u306b\u304a\u3051\u308b\u03b1-Gal\u3084\u03b1-GalNAc\u306e\u4ed8\u52a0\u306f\u3001Fuc\u03b11-2 \u306e\u8a8d\u8b58\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/SapL1_GlycanBindingSpecificities.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/SapL1_GlycanBindingSpecificities-300x168.png\" alt=\"\" width=\"300\" height=\"168\" class=\"alignnone size-medium wp-image-5886\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/SapL1_GlycanBindingSpecificities-300x168.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/SapL1_GlycanBindingSpecificities-600x335.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/SapL1_GlycanBindingSpecificities-1024x573.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/SapL1_GlycanBindingSpecificities-768x429.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/SapL1_GlycanBindingSpecificities.png 1268w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Univ. Grenoble Alpes, France\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u771f\u83cc\u3067\u3042\u308b\u30b9\u30b1\u30c9\u30b9\u30dd\u30ea\u30a6\u30e0\u30fb\u30a2\u30d4\u30aa\u30b9\u30da\u30eb\u30e0\u30e0\u304c\u6301\u3064\u30ec\u30af\u30c1\u30f3\u3001Scedosporium apiospermum Lectin 1 (SapL1)\u3001\u306e\u7cd6<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e8%82%ba%e6%84%9f%e6%9f%93%e7%97%87%e3%82%92%e5%bc%95%e3%81%8d%e8%b5%b7%e3%81%93%e3%81%99%e3%82%b9%e3%82%b1%e3%83%89%e3%82%b9%e3%83%9d%e3%83%aa%e3%82%a6%e3%83%a0%e5%b1%9e%e3%81%af%e3%80%81%e3%83%95\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-5884","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Univ. 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