{"id":5860,"date":"2021-08-21T09:32:28","date_gmt":"2021-08-21T00:32:28","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5860"},"modified":"2021-08-22T08:23:57","modified_gmt":"2021-08-21T23:23:57","slug":"covid-19%e9%87%8d%e7%97%87%e5%8c%96%e3%81%ae%e8%b5%b7%e7%82%b9%e3%81%af%e3%80%81%e3%83%91%e3%82%a4%e3%83%ad%e3%83%88%e3%83%bc%e3%82%b7%e3%82%b9%e3%81%ab%e3%81%82%e3%82%8b%ef%bc%9a%e8%a1%80%e4%b8%ad","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/covid-19%e9%87%8d%e7%97%87%e5%8c%96%e3%81%ae%e8%b5%b7%e7%82%b9%e3%81%af%e3%80%81%e3%83%91%e3%82%a4%e3%83%ad%e3%83%88%e3%83%bc%e3%82%b7%e3%82%b9%e3%81%ab%e3%81%82%e3%82%8b%ef%bc%9a%e8%a1%80%e4%b8%ad\/","title":{"rendered":"COVID-19\u91cd\u75c7\u5316\u306e\u8d77\u70b9\u306f\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u3042\u308b\uff1a\u8840\u4e2d\u306e\u5358\u7403\u306e10%\u3001\u80ba\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e8%\u304c\u3001SARS-CoV-2\u306e\u611f\u67d3\u3092\u53d7\u3051\u3066\u3044\u308b"},"content":{"rendered":"

Harvard Medical School, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306e\u60a3\u8005\u3067\u306f\u3001\u8840\u4e2d\u306e\u5358\u7403\u306e10%\u3001\u80ba\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e8%\u304cSARS-CoV-2\u306b\u611f\u67d3\u3057\u3066\u304a\u308a\u3001Fc\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u6297\u4f53\u30fb\u30a6\u30a4\u30eb\u30b9\u7d50\u5408\u4f53\u304c\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8a98\u8d77\u3055\u308c\u308b\u708e\u75c7\u6027\u7d30\u80de\u6b7b\uff08\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\uff09\u304cCOVID-19\u306b\u3068\u3063\u3066\u8af8\u5203\u306e\u5263\u306b\u306a\u3063\u3066\u3044\u308b\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.researchsquare.com\/article\/rs-153628\/v1<\/a><\/p>\n

SARS-CoV-2\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u304b\u306b\u3064\u3044\u3066\u3001\u672a\u3060\u306b\u305d\u306e\u5168\u5bb9\u304c\u5b8c\u5168\u306b\u7406\u89e3\u3055\u308c\u3066\u304a\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u5358\u7403\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u3001\u305d\u308c\u305e\u308c\u3001\u8840\u4e2d\u304a\u3088\u3073\u7d44\u7e54\u306b\u304a\u3051\u308b\u3001\u514d\u75ab\u306e\u6700\u524d\u7dda\u306b\u3044\u308b\u514d\u75ab\u7d30\u80de\u3067\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u514d\u75ab\u7d30\u80de\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u4fb5\u5165\u3092\u611f\u77e5\u3059\u308b\u3068\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u5f62\u6210\u3057\u3001caspase-1\u3084\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D (GSDMD) \u3092\u6d3b\u6027\u5316\u3057\u3001\u708e\u75c7\u6027\u7d30\u80de\u6b7b\u3092\u8a98\u8d77\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u653e\u51fa\u3057\u307e\u3059\u3002 <\/p>\n

\u5358\u7403\u306f\u3001\u4e00\u822c\u7684\u306bACE2\u306f\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\u3068\u3055\u308c\u3001\u5b9f\u969b\u3001\u5065\u5e38\u8005\uff08HD\uff09\u306e\u5358\u7403\u3082\u3001SARS-CoV-2\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u305f\u5358\u7403\u306b\u304a\u3044\u3066\u3082\u3001ACE2\u306e\u767a\u73fe\u306f\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30fc\u30bf\u3067\u3082qRT-PCR\u3067\u3082\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5358\u7403\u306b\u306f\uff12\u7a2e\u306eFcg\u53d7\u5bb9\u4f53\u304c\u5b58\u5728\u3057\u307e\u3059\u3001\u4e00\u3064\u306fCD32\uff08FcgRII\u3001\u307b\u3068\u3093\u3069\u306e\u8840\u4e2d\u5358\u7403\u306b\u5b58\u5728\uff09\u3067\u3042\u308a\u3001\u3082\u3046\u4e00\u3064\u306fCD16\uff08FcgRIII\u3001COVID-19\u306e\u60a3\u8005\u3067\u767a\u73fe\uff09\u3067\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u53d7\u5bb9\u4f53\u306f\u3001\u6297\u4f53\u30fb\u30a6\u30a4\u30eb\u30b9\u7d50\u5408\u4f53\u3092\u8a8d\u8b58\u3057\u3001\u6297\u4f53\u4f9d\u5b58\u6027\u8caa\u98df\u4f5c\u7528\uff08ADP\uff09\u306b\u3088\u3063\u3066\u30a6\u30a4\u30eb\u30b9\u3092\u53d6\u308a\u8fbc\u307f\u307e\u3059\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3084\u4ed6\u306e\u7d30\u80de\u58ca\u6b7b\u306e\u75c5\u7406\u7684\u306a\u7279\u5fb4\u3068\u3057\u3066\u306f\u3001LDH\u306e\u3088\u3046\u306a\u5de8\u5927\u5206\u5b50\u306e\u653e\u51fa\u304c\u3042\u308a\u307e\u3059\u3002\u5b9f\u969b\u3001LDH\u306e\u4e0a\u6607\u306f\u3001\u91cd\u5ea6\u306eCOVID-19\u3068\u512a\u308c\u305f\u76f8\u95a2\u3092\u793a\u3057\u3001\u8840\u4e2d\u306eGSDMD\u3001IL-1RA\u3001IL-18\u3082\u91cd\u5ea6\u306eCOVID-19\u3067\u9855\u8457\u306b\u5897\u52a0\u3001GSDMD eOTLs\u306f\u3001COVID-19\u306e\u6025\u6027\u547c\u5438\u5668\u4e0d\u5168\u3068\u6700\u3082\u9855\u8457\u306b\u76f8\u95a2\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u30a6\u30a4\u30eb\u30b9\u3092\u53d6\u308a\u8fbc\u3093\u3060\u5f8c\u3001SARS-CoV-2\u306f\u5358\u7403\u5185\u3067\u5897\u6b96\u3057\u3066\u304a\u308a\u3001\u5b9f\u969b\u3001dsRNA\u306e\u691c\u51fa\u306a\u3069\u306b\u3088\u308a\u305d\u306e\u3053\u3068\u306f\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u611f\u67d3\u306f\u4e2d\u65ad\u3055\u308c\u3001\u611f\u67d3\u3055\u308c\u305f\u7d30\u80de\u306f\u3001NLRP3\u3001AIM2 inflammasome\u3001caspase-1 \u3001GSDMD\u3089\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u708e\u75c7\u6027\u7d30\u80de\u6b7b\u3092\u9042\u3052\u307e\u3059\u3002\u66f4\u306b\u3001COVID-19\u3067\u75c5\u6b7b\u3057\u305f\u60a3\u8005\u306e\u80ba\u306e\u691c\u6b7b\u304b\u3089\u5f97\u3089\u308c\u305f\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u3001\u540c\u3058\u3088\u3046\u306a\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u3092\u793a\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u6297\u4f53\u3092\u4ecb\u3057\u305fSARS-CoV-2\u306e\u5358\u7403\u3084\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u611f\u67d3\u304c\u3001\u708e\u75c7\u6027\u7d30\u80de\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u306f\u6b62\u307e\u308b\u306e\u3067\u3059\u304c\u3001\u540c\u6642\u306b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u653e\u51fa\u3057\u3001COVID-19\u306e\u91cd\u75c7\u5316\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Harvard Medical School, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306e\u60a3\u8005\u3067\u306f\u3001\u8840\u4e2d\u306e\u5358\u7403\u306e10%\u3001\u80ba\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e8%\u304cSARS-CoV-2\u306b\u611f\u67d3\u3057\u3066\u304a\u308a\u3001Fc\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u6297\u4f53\u30fb\u30a6\u30a4\u30eb\u30b9\u7d50\u5408\u4f53\u304c<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-5860","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5860"}],"version-history":[{"count":19,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5860\/revisions"}],"predecessor-version":[{"id":5882,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5860\/revisions\/5882"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5860"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5860"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}