{"id":5832,"date":"2021-08-19T07:17:31","date_gmt":"2021-08-18T22:17:31","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5832"},"modified":"2021-08-22T08:26:35","modified_gmt":"2021-08-21T23:26:35","slug":"hmgb1-released-from-respiratory-infection-in-covid-19-stimulates-trigeminal-neurons-and-causes-covid-19-headache","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/hmgb1-released-from-respiratory-infection-in-covid-19-stimulates-trigeminal-neurons-and-causes-covid-19-headache\/","title":{"rendered":"HMGB1 released from respiratory infection in COVID-19 stimulates trigeminal neurons and causes COVID-19 headache"},"content":{"rendered":"<p>A group from Gazi University Hospital, Medical Faculty, Besevler, Ankara, Turkey, etc. has first reported that HMGB1 released from respiratory infection in COVID-19 stimulates trigeminal neurons and causes COVID-19 headache.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8358545\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8358545\/<\/a><\/p>\n<p>COVID-19 patients suffered from headache had significantly higher serum levels of HMGB1, NLRP3, ACE2, and IL-6 than COVID-19 patients without headache, whereas CGRP and IL-10 levels were similar in the groups.<\/p>\n<p>Taken all the data together, it was suggested that HMGB1 as a potent proinflammatory molecule with nociceptive properties would be a central player in proinflammatory reactions during SARS-Co-V2 infection and induce headache through activation of trigeminal neurons.<\/p>\n<p>Extracellular HMGB1 is secreted from activated macrophages, monocytes natural killer cells and dendritic cells in response to pathogen invasion such as SARS-CoV-2. Neurons, astrocytes, microglia, and endothelial cells are also able to actively secrete HMGB1 after exposure to cytokines, interferons, etc. Furthermore, cell injury and necrotic process caused by ARDS of COVID-19 can greatly contribute to increase of serum levels of HMGB1. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Gazi University Hospital, Medical Faculty, Besevler, Ankara, Turkey, etc. has first reported that<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/hmgb1-released-from-respiratory-infection-in-covid-19-stimulates-trigeminal-neurons-and-causes-covid-19-headache\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-5832","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"A group from Gazi University Hospital, Medical Faculty,\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/en\/hmgb1-released-from-respiratory-infection-in-covid-19-stimulates-trigeminal-neurons-and-causes-covid-19-headache\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"ja_JP\" \/>\n\t\t<meta 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