{"id":5782,"date":"2021-08-17T10:16:05","date_gmt":"2021-08-17T01:16:05","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5782"},"modified":"2021-08-22T08:27:37","modified_gmt":"2021-08-21T23:27:37","slug":"galectin-%ef%bc%93-could-be-a-good-prognostic-marker-against-severe-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/galectin-%ef%bc%93-could-be-a-good-prognostic-marker-against-severe-covid-19\/","title":{"rendered":"Galectin-\uff13 could be a GOOD prognostic marker against severe COVID-19"},"content":{"rendered":"

A group from University of Medicine \u201cAldo Moro\u201d, Bari, Italy, etc. has reported on prognostic power of Galectin-3 against severe COVID-19.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8332745\/<\/a><\/p>\n

This is the first study in scientific literature assessing the prognostic role of Galectin-3 in acute respiratory failure secondary to COVID-19 disease. Patients with higher serum levels of Galectin-3 tend to develop a more severe degree of ARDS with a worse prognosis. It is well known that SARS-COV2 infection can lead to the so called \u201ccytokine storm\u201d in some susceptible patients. For instance, our non-survivors group shows increased blood levels of various inflammation markers, which are frequently associated with negative outcomes in COVID-19 disease. Nevertheless, only IL-6, CRP and Galectin-3 remain statistically significant in our multivariate regression model. This finding is not surprising for IL-6 and CRP, which were previously reported as important prognostic markers in COVID-19 disease. On the contrary, this is the first study addressing this role for Galectin-3. Furthermore, among the explored parameters, Galectin-3 shows the best AUC curve in ROC analysis, showing good diagnostic power for severe ARDS (AUC 0.75, p = 0.001) using a cut-off value of 35.3 ng\/ml.<\/p>\n

In fact, patients with Galectin-3 serum levels above 35.3 ng\/ml were not only more prone to develop severe ARDS, but also markedly at higher risk of ICU admission or death. The cohort size of this study was 156 patients.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from University of Medicine \u201cAldo Moro\u201d, Bari, Italy, etc. has reported on prognostic power of Galecti<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-5782","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t