{"id":5772,"date":"2021-08-16T07:47:27","date_gmt":"2021-08-15T22:47:27","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5772"},"modified":"2021-08-25T06:37:16","modified_gmt":"2021-08-24T21:37:16","slug":"anti-spike-antibody-attached-gold-nanoparticles-gnps-have-the-capability-to-inhibit-sars-cov-2-infection-perfectly","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/anti-spike-antibody-attached-gold-nanoparticles-gnps-have-the-capability-to-inhibit-sars-cov-2-infection-perfectly\/","title":{"rendered":"Anti-spike antibody attached gold nanoparticles (GNPs) have the capability to inhibit SARS-CoV-2 infection perfectly"},"content":{"rendered":"

A group from Jackson State University, USA, etc. has reported anti-spike antibody attached gold nanoparticles (GNPs) have the capability to inhibit SARS-CoV-2 infection perfectly.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8323809\/<\/a><\/p>\n

Citrate coated original size of GNPs was 15 \u00b1 2 nm, and the size of GNPs increased to \u223c27 \u00b1 6 nm by conjugating antibodies. <\/p>\n

Pseudo SARS-CoV-2 (# C1110G, Montana Molecular, Bozeman, MT) was used as the model virus, and HEK293T cells were used as host cells, which express ACE2 known as infection receptor of SARS-CoV-2.<\/p>\n

As shown below, anti-spike antibody attached gold nanoparticles block viral replication and virus spread in HEK293T cells. It was found that the inhibition efficiency was 100% for 100 ng\/mL anti-spike antibody attached gold nanoparticles and 60% for 10 ng\/mL anti-spike antibody attached GNPs. In contrast, our experimental data indicate that the inhibition efficiencies for PEG coated GNPs and 100 ng mL\u22121 antibody only were less than 1%.<\/p>\n

< a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/GNPantibody_SARS-CoV-2.png\">\"\"<\/a><\/p>\n

However, blog admin does not know if this method could be used in vivo.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Jackson State University, USA, etc. has reported anti-spike antibody attached gold nanoparticles <\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-5772","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t