{"id":574,"date":"2020-08-02T12:12:20","date_gmt":"2020-08-02T03:12:20","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=574"},"modified":"2021-07-22T00:06:10","modified_gmt":"2021-07-21T15:06:10","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e6%84%9f%e6%9f%93%e8%83%bd","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e6%84%9f%e6%9f%93%e8%83%bd\/","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306e\u611f\u67d3\u80fd\u306b\u7cd6\u9396\u306f\u3069\u3046\u7d61\u3080\u306e\u304b\uff1f"},"content":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u7b2c\u4e8c\u6ce2\u304c\u8972\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u6628\u65e5\u306f\u6771\u4eac\u306e\u65b0\u898f\u611f\u67d3\u8005\u6570\u306f472\u4eba\u306b\u9054\u3057\u305f\u3068\u306e\u3053\u3068\u3002\u5927\u962a\uff1d195\u4eba\u3001\u611b\u77e5\uff1d181\u4eba\u3001\u798f\u5ca1\uff1d121\u4eba\u3001\u5927\u90fd\u5e02\u306f\u4f55\u51e6\u3082100\u4eba\u8d8a\u3048\u3067\u3059\u3002<\/p>\n<div><\/div>\n<div>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u95a2\u3059\u308b\u7814\u7a76\u9032\u5c55\u306e\u901f\u3055\u3068\u51fa\u7248\u3055\u308c\u308b\u8ad6\u6587\u306e\u6025\u5897\u306b\u306f\u9a5a\u304f\u3070\u304b\u308a\u3067\u3059\u3002Pubmed\u306b\u3066\u3001COVID-19\u3092\u30ad\u30fc\u30ef\u30fc\u30c9\u3068\u3057\u3066\u691c\u7d22\u3057\u307e\u3059\u3068\u3001\u4eca\u65e5\u73fe\u5728\u306737,700\u4ef6\u3092\u8d85\u3048\u308b\u8ad6\u6587\u304c\u65e2\u306b\u51fa\u7248\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SRAS-CoV-2\uff09\u304c\u30d2\u30c8\u306b\u611f\u67d3\u3059\u308b\u5834\u5408\u306b\u3001\u305d\u306e\u611f\u67d3\u958b\u59cb\u306e\u304d\u3063\u304b\u3051\u3068\u306a\u308b\u7d30\u80de\u306e\u53d7\u5bb9\u4f53\u306fACE2\uff08Angiotensin Converting Enzyme 2\uff09\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u4e8b\u304c\u5b9a\u8aac\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u4e0b\u8a18\u306e\u8ad6\u6587\u304c\u53c2\u8003\u306b\u306a\u308a\u307e\u3059\u3002\u56e0\u307f\u306b\u3001SARS-CoV\u3082ACE2\u304c\u611f\u67d3\u53d7\u5bb9\u4f53\u3067\u3042\u308a\u3001MERS-CoV\u3067\u306f\u3001DPP4;CD26\u304c\u611f\u67d3\u53d7\u5bb9\u4f53\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/div>\n<div><a href=\"https:\/\/science.sciencemag.org\/content\/367\/6485\/1444\/tab-pdf\">https:\/\/science.sciencemag.org\/content\/367\/6485\/1444\/tab-pdf<\/a><\/div>\n<div><a href=\"https:\/\/science.sciencemag.org\/content\/367\/6483\/1260\/tab-pdf\">https:\/\/science.sciencemag.org\/content\/367\/6483\/1260\/tab-pdf<\/a><\/div>\n<p>&nbsp;<\/p>\n<div>\u3057\u304b\u3057\u3001ACE2\u4ee5\u5916\u306b\u3001ANPEP\uff08Alanyl Aminopeptidase\uff09, DPP4\uff08Dipeptidyl Peptidase-4\uff09\u3082\u611f\u67d3\u53d7\u5bb9\u4f53\u306b\u306a\u308a\u3046\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002<\/div>\n<div><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7156119\/pdf\/main.pdf\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7156119\/pdf\/main.pdf<\/a><\/div>\n<p>&nbsp;<\/p>\n<div>\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7cd6\u9396\u4fee\u98fe\u3092\u53d7\u3051\u3066\u3044\u308b\u3053\u3068\u306b\u306f\u307b\u3068\u3093\u3069\u4f8b\u5916\u304c\u306a\u304f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\uff08S\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3082\u3001\u611f\u67d3\u53d7\u5bb9\u4f53\u3068\u306a\u308bACE2\u3089\u3082\u7cd6\u9396\u4fee\u98fe\u3092\u5f37\u304f\u53d7\u3051\u3066\u3044\u307e\u3059\u3002<\/div>\n<div>\u4f8b\u3048\u3070\u3001\u4e0b\u8a18\u306e\u8ad6\u6587\u3067\u306f\u3001S\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3064\u3044\u3066\u3001Oligomannose\u304b\u3089\u3001Hybrid\u578b\u3001Complex\u578b\u307e\u3067\u591a\u69d8\u306aN\u578b\u7cd6\u9396\u69cb\u9020\u304c\u767a\u73fe\u3057\u3066\u304a\u308a\u3001O\u578b\u7cd6\u9396\u306b\u3064\u3044\u3066\u3082\u3001Core1, Core2\u30bf\u30a4\u30d7\u306e\u7cd6\u9396\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/div>\n<div><a href=\"https:\/\/science.sciencemag.org\/content\/369\/6501\/330\/tab-pdf\">https:\/\/science.sciencemag.org\/content\/369\/6501\/330\/tab-pdf<\/a><\/div>\n<p>&nbsp;<\/p>\n<div>\u4e00\u65b9\u3001ACE2\u306b\u3064\u3044\u3066\u3082\u3001\u305d\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u6982\u8981\u304c\u4e0b\u8a18\u306e\u8ad6\u6587\u306b\u8a18\u8f09\u3055\u308c\u3066\u304a\u308a\u3001S\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7cd6\u9396\u4fee\u98fe\u540c\u69d8\u306b\u3001\u975e\u5e38\u306b\u591a\u69d8\u306a\u7cd6\u9396\u304c\u540c\u69d8\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/div>\n<div><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.05.01.071688v1.full.pdf\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.05.01.071688v1.full.pdf<\/a><\/div>\n<p>&nbsp;<\/p>\n<div>\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u3001S\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3082\u611f\u67d3\u53d7\u5bb9\u4f53\u5074\u306b\u3082\u591a\u69d8\u306a\u7cd6\u9396\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u4ee5\u4e0a\u3001\u7cd6\u9396\u3092\u4ecb\u5728\u3057\u305f\u611f\u67d3\u958b\u59cb\u3082\u5fc5\u305a\u3084\u3042\u308b\u306f\u305a\u3067\u3059\u3002\u4e0b\u8a18\u306e\u8ad6\u6587\u3067\u306f\u3001S\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3001\u53d7\u5bb9\u4f53\u306eC\u30bf\u30a4\u30d7\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308bDC-SIGN\u3084MGL\u3068\u5f37\u304f\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u30b7\u30a2\u30eb\u9178\u8a8d\u8b58\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308bSiglec-3, -9, -10\u3068\u3082\u5f37\u304f\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/div>\n<div><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.05.13.092478v1.full.pdf\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.05.13.092478v1.full.pdf<\/a><\/div>\n<p>&nbsp;<\/p>\n<div>\u5f93\u3063\u3066\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u611f\u67d3\u306f\u3001ACE2\u4e00\u8fba\u5012\u3067\u306f\u306a\u304f\u3001\u30da\u30d7\u30c1\u30c0\u30fc\u30bc\u3067\u3042\u308b\uff08ANPEP, DPP4\uff09\u3068\u3001C\u30bf\u30a4\u30d7\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308b\uff08DC-SIGN, MGL\uff09\u3001\u305d\u308c\u306bSiglec\u3082\u95a2\u4fc2\u3057\u3066\u8907\u96d1\u306a\u611f\u67d3\u7d4c\u8def\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3057\u304b\u3082\u3001\u3053\u308c\u3089\u306e\u53d7\u5bb9\u4f53\u306f\u3001\u514d\u75ab\u7d30\u80de\u3082\u542b\u3081\u3001\u4f53\u5185\u306e\u7d44\u7e54\u306b\u5e83\u304f\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002<\/div>\n<p>&nbsp;<\/p>\n<div>\u66f4\u306b\u8208\u5473\u6df1\u3044\u306e\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u91cd\u75c7\u5316\u306bABO\u8840\u6db2\u578b\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u5831\u544a\u3067\u3059\u3002<\/div>\n<div><a href=\"https:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2020283?articleTools=true\">https:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2020283?articleTools=true<\/a><\/div>\n<div>\u3053\u306e\u8ad6\u6587\u306f\u3001A\u578b\u306e\u30d2\u30c8\u306fO\u578b\u306e\u30d2\u30c8\u306b\u6bd4\u3079\u3066\u30012.2\u500d\u307b\u3069\u91cd\u75c7\u5316\u3057\u3084\u3059\u3044\u3068\u3044\u3046\u3053\u3068\u3092\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u6297A\u578b\u6297\u4f53\u304c\u3001SARS-CoV-2\u306e\u611f\u67d3\u6291\u5236\u306b\u591a\u5c11\u3068\u3082\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u307e\u3059\u3002\u6297A\u578b\u6297\u4f53\u306f\u3001\u4e0b\u8a18\u306eA\u578b\u6297\u539f\uff08GalNAc\u03b1\uff11-3(Fuc\u03b11-2)Gal\u03b21-4GlcNAc\uff09\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3067\u3059\u306e\u3067\u3001\u3053\u306e\u7a2e\u306e\u7cd6\u9396\u69cb\u9020\u304c\u4f55\u3089\u304b\u306e\u5f62\u3067\u611f\u67d3\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u304c\u7121\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/div>\n<div><\/div>\n<div><a href=\"http:\/\/www.glycotechnica.com\/blog\/glycostation\/ABO.png\"><img loading=\"lazy\" decoding=\"async\" class=\"mt-image-left\" src=\"http:\/\/www.glycotechnica.com\/blog\/glycostation\/assets_c\/2020\/08\/ABO-thumb-400x125-41.png\" alt=\"ABO.png\u306e\u30b5\u30e0\u30cd\u30a4\u30eb\u753b\u50cf\" width=\"400\" height=\"125\"><\/a><\/div>\n<p>&nbsp;<\/p>\n<div>\u66f4\u306b\u4e0d\u601d\u8b70\u306a\u306e\u304c\u3001\u30d5\u30a1\u30af\u30bf\u30fc\uff38\u306e\u5b58\u5728\u3067\u3059\u3002\u306a\u305c\u3001\u30a2\u30b8\u30a2\u30aa\u30bb\u30a2\u30cb\u30a2\u3067\u306f\u3001\u6b7b\u4ea1\u7387\u304c\u6b27\u7c73\u3088\u308a\u3051\u305f\u9055\u3044\u306b\u5c0f\u3055\u3044\u306e\u304b\uff1f<\/div>\n<div><a href=\"https:\/\/www.covid19-yamanaka.com\/cont11\/main.html\">https:\/\/www.covid19-yamanaka.com\/cont11\/main.html<\/a><\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u7b2c\u4e8c\u6ce2\u304c\u8972\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u6628\u65e5\u306f\u6771\u4eac\u306e\u65b0\u898f\u611f\u67d3\u8005\u6570\u306f472\u4eba\u306b\u9054\u3057\u305f\u3068\u306e\u3053\u3068\u3002\u5927\u962a\uff1d195\u4eba\u3001\u611b\u77e5\uff1d181\u4eba\u3001\u798f\u5ca1\uff1d121\u4eba\u3001\u5927\u90fd\u5e02\u306f\u4f55\u51e6\u3082100\u4eba\u8d8a\u3048\u3067\u3059\u3002 \u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u95a2\u3059\u308b\u7814\u7a76\u9032\u5c55\u306e\u901f\u3055<\/p><\/div>\n<div class=\"blog-btn\"><a 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