{"id":5728,"date":"2021-08-14T06:17:49","date_gmt":"2021-08-13T21:17:49","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5728"},"modified":"2021-08-22T08:29:23","modified_gmt":"2021-08-21T23:29:23","slug":"four-mirnas-that-are-remarkably-decreased-in-the-elderly-and-diabetic-individuals-can-inhibit-sars-cov-2-replication","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/four-mirnas-that-are-remarkably-decreased-in-the-elderly-and-diabetic-individuals-can-inhibit-sars-cov-2-replication\/","title":{"rendered":"Four miRNAs that are remarkably decreased in the elderly and diabetic individuals can inhibit SARS-CoV-2 replication."},"content":{"rendered":"

A group from School of Life Sciences, Nanjing University, Nanjing, China, etc. has reported four miRNAs (miR-7-5p, miR-24-3p, miR-145-5p and miR-223-3p) that are remarkably decreased in the elderly and diabetic individuals can inhibit SARS-CoV-2 replication.
\nhttps:\/\/www.nature.com\/articles\/s41392-021-00716-y<\/a><\/p>\n

To comprehensively investigate the differences in circulating miRNA expression patterns in the serum between young and elderly people, age-related non-coding RNA expression profiles obtained by high-throughput sequencing from the NCBI Gene Expression Omnibus database were downloaded. A total of 13 samples (3 young, age <30 and 10 old, age >60) were analyzed, and differentially expressed miRNAs were screened and identified.<\/p>\n

Quite interestingly, it was found that four miRNAs (miR-7-5p, miR-24-3p, miR-145-5p and miR-223-3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups. <\/p>\n

Then, it was demonstrated that these miRNAs, either in the exosome or in the free form, can directly inhibit S protein expression and SARS-CoV-2 replication. A figure below shows the case of exosome.<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from School of Life Sciences, Nanjing University, Nanjing, China, etc. has reported four miRNAs (miR-7<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-5728","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t