{"id":5720,"date":"2021-08-13T16:06:44","date_gmt":"2021-08-13T07:06:44","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5720"},"modified":"2021-08-22T08:30:08","modified_gmt":"2021-08-21T23:30:08","slug":"mapping-of-sars-cov-2-spike-glycoprotein-derived-antigens-presented-by-hla-class-ii-on-dendritic-cells-how-glycosylation-is-different-from-the-original","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/mapping-of-sars-cov-2-spike-glycoprotein-derived-antigens-presented-by-hla-class-ii-on-dendritic-cells-how-glycosylation-is-different-from-the-original\/","title":{"rendered":"Mapping of SARS-CoV-2 spike glycoprotein-derived antigens presented by HLA class II on dendritic cells: how glycosylation is different from the original"},"content":{"rendered":"

A group from University of Oxford, UK, etc. has reported on mapping of SARS-CoV-2 spike glycoprotein-derived antigens presented by HLA class II on dendritic cells.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8116342\/<\/a><\/p>\n

It is very curious for blog admin whether HLA-II bound glycopeptides presented as SARS-CoV-2-specific antigens on dendritic cells have the same glycosylation as phagocytized SARS-CoV-2 by dendritic cells.<\/p>\n

HLA-II-bound glycopeptides were identified from 14 N-linked glycosylation sites in Spike from total 22 glycosylation sites. HLA-II-bound peptides carried predominantly short paucimannosidic-type N-glycans while original Spike carried oligomannosidic- and GlcNAc-capped complex-type N-glycan structures at these sites. The paucimannosylation of the HLA-II-bound peptides comprised both core-fucosylated and fucosylated species. This reveals there is substantial trimming of glycan residues on the glycopeptides during antigen processing in dendritic cells.<\/p>\n

\"\"<\/a>
\nThe heatmap colors in a figure above indicate the relative frequency of each glycan composition present, and the total number of peptide spectral matches (PSM) is also shown (blue bars).<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from University of Oxford, UK, etc. has reported on mapping of SARS-CoV-2 spike glycoprotein-derived a<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-5720","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5720"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5720\/revisions"}],"predecessor-version":[{"id":5721,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5720\/revisions\/5721"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}