{"id":5646,"date":"2021-08-11T11:57:57","date_gmt":"2021-08-11T02:57:57","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5646"},"modified":"2021-08-11T11:57:57","modified_gmt":"2021-08-11T02:57:57","slug":"sars-cov-2-rbd%e3%82%92%e3%83%96%e3%83%ad%e3%83%83%e3%82%af%e3%81%a7%e3%81%8d%e3%82%8b%e3%82%ad%e3%83%88%e3%82%b5%e3%83%b3%e3%81%af%e3%80%81covid-19%e3%81%ae%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a8","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2-rbd%e3%82%92%e3%83%96%e3%83%ad%e3%83%83%e3%82%af%e3%81%a7%e3%81%8d%e3%82%8b%e3%82%ad%e3%83%88%e3%82%b5%e3%83%b3%e3%81%af%e3%80%81covid-19%e3%81%ae%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a8\/","title":{"rendered":"SARS-CoV-2 RBD\u3092\u30d6\u30ed\u30c3\u30af\u3067\u304d\u308b\u30ad\u30c8\u30b5\u30f3\u306f\u3001COVID-19\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u671f\u5f85\u3067\u304d\u308b"},"content":{"rendered":"<p>Birla Institute of Technology and Sciences (BITS), Rajasthan, India\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30ad\u30c8\u30b5\u30f3\u6d3e\u751f\u7269\u304cSARS-CoV-2\u306e\u91ce\u751f\u682a\u53ca\u3073\u305d\u306e\u5909\u7570\u682a\u306e\u611f\u67d3\u306b\u5bfe\u3057\u3066\u3001\u65b0\u898f\u306e\u963b\u5bb3\u5264\u306b\u306a\u308a\u5f97\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8313795\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8313795\/<\/a><\/p>\n<p>\u30ad\u30c8\u30b5\u30f3\u6d3e\u751f\u7269\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u3001SARS-CoV-2\u306e\u91ce\u751f\u682a\u306eRBD\u3001\u53ca\u3073\u5909\u7570\u682a\uff08\u30a2\u30eb\u30d5\u30a1\u304a\u3088\u3073\u30ac\u30f3\u30de\uff09\u306eRBD\u306b\u5bfe\u3057\u3066\u3001\u5206\u5b50\u52d5\u529b\u5b66\u7684\u30c9\u30c3\u30ad\u30f3\u30b0\u30fb\u30b7\u30e5\u30df\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u7528\u3044\u3066\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u5f97\u3089\u308c\u305f\u7d50\u679c\u306f\u975e\u5e38\u306b\u8208\u5473\u6df1\u304f\u3001Imino-\u30ad\u30c8\u30b5\u30f3\u3068N-benzyl-O-acetyl-\u30ad\u30c8\u30b5\u30f3\u304c\u3001SARS-CoV-2 Spike RBD\u306b\u5bfe\u3057\u3066\u5f37\u3044\u7d50\u5408\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u793a\u3057\u307e\u3057\u305f\uff08-6.4 \uff5e -6.7 kcal\/mol\uff09\u3002 <\/p>\n<p>\u4e21\u5316\u5408\u7269\u306eRBD\u306e\u9759\u96fb\u6c17\u7684\u8868\u9762\u4e0a\u306b\u304a\u3051\u308b\u914d\u4f4d\u30e2\u30c7\u30eb\u3092\u4e0b\u8a18\u306b\u793a\u3057\u307e\u3059\u3001<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/chitosan-on-SARS-CoV-2-RBD.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/chitosan-on-SARS-CoV-2-RBD-300x165.png\" alt=\"\" width=\"300\" height=\"165\" class=\"alignnone size-medium wp-image-5647\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/chitosan-on-SARS-CoV-2-RBD-300x165.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/chitosan-on-SARS-CoV-2-RBD-600x330.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/chitosan-on-SARS-CoV-2-RBD.png 676w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u30b7\u30c8\u30af\u30ed\u30e0P450 (CYP450)\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u30df\u30af\u30ed\u30bd\u30fc\u30e0\u9175\u7d20\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u751f\u4f53\u306e\u7570\u7269\u4ee3\u8b1d\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002CYP3A4\u3001CYP3A2\u3001CYP2C9\u3001CYP2C19\u3001CYP2D6 \u306f\u3059\u3079\u3066CY450\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3042\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u85ac\u7269\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u85ac\u7269\u306e\u7406\u60f3\u7684\u306a\u30b7\u30ca\u30ea\u30aa\u3068\u306f\u3001\u3053\u308c\u3089\u306e\u9175\u7d20\u3092\u963b\u5bb3\u3057\u306a\u3044\u3053\u3068\u3067\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u70b9\u306b\u304a\u3044\u3066\u3001Imino-\u30ad\u30c8\u30b5\u30f3 \u3068 N-benzyl-o-acetyl-\u30ad\u30c8\u30b5\u30f3 \u306f\u3001\u4e21\u65b9\u3068\u3082\u307e\u3068\u3082\u306a\u85ac\u7269\u306b\u306a\u308a\u5f97\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>Imino-\u30ad\u30c8\u30b5\u30f3 \u3068 N-benzyl-o-acetyl-\u30ad\u30c8\u30b5\u30f3\u306e\u6bd2\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u3001\u30e9\u30c3\u30c8\u304a\u3088\u3073\u30de\u30a6\u30b9\u3067\u306e\u767a\u304c\u3093\u6027\u8a66\u9a13\u3001\u304a\u3088\u3073HERG\u963b\u5bb3\u7d50\u679c\u3092\u4f7f\u7528\u3057\u3066\u3001\u5909\u7570\u539f\u6027\u304a\u3088\u3073\u767a\u304c\u3093\u6027\u306b\u57fa\u3065\u3044\u3066\u6c7a\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u6bd2\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u3059\u3079\u3066\u306e\u7d50\u679c\u306f\u826f\u597d\u3067\u3042\u308a\u3001\u30ea\u30ac\u30f3\u30c9\u304c\u6f5c\u5728\u7684\u306a\u85ac\u7269\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Birla Institute of Technology and Sciences (BITS), Rajasthan, India\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30ad\u30c8\u30b5\u30f3\u6d3e\u751f\u7269\u304cSARS-CoV-2\u306e\u91ce\u751f\u682a\u53ca\u3073\u305d\u306e\u5909\u7570\u682a\u306e\u611f\u67d3\u306b\u5bfe\u3057<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2-rbd%e3%82%92%e3%83%96%e3%83%ad%e3%83%83%e3%82%af%e3%81%a7%e3%81%8d%e3%82%8b%e3%82%ad%e3%83%88%e3%82%b5%e3%83%b3%e3%81%af%e3%80%81covid-19%e3%81%ae%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a8\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-5646","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5646"}],"version-history":[{"count":7,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5646\/revisions"}],"predecessor-version":[{"id":5654,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5646\/revisions\/5654"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5646"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}