{"id":5544,"date":"2021-08-06T10:19:12","date_gmt":"2021-08-06T01:19:12","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5544"},"modified":"2021-08-07T11:07:00","modified_gmt":"2021-08-07T02:07:00","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88covid-19%ef%bc%89%e3%81%ae%e7%89%b9%e5%be%b4%e7%9a%84%e3%81%aa%e3%81%b5%e3%81%9f%e3%81%a4%e3%81%ae%e3%82%b0","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88covid-19%ef%bc%89%e3%81%ae%e7%89%b9%e5%be%b4%e7%9a%84%e3%81%aa%e3%81%b5%e3%81%9f%e3%81%a4%e3%81%ae%e3%82%b0\/","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u306e\u7279\u5fb4\u7684\u306a\u3075\u305f\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u898b\u3089\u308c\u308b\u514d\u75ab\u53cd\u5fdc\u306e\u9055\u3044\u3068\u91cd\u75c7\u5ea6\u3068\u306e\u76f8\u95a2\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>Sorbonne Universite, Inserm, Universite de Paris, France\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u306e\u7570\u306a\u3063\u305f\u514d\u75ab\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6301\u3064\u4e8c\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u3092\u540c\u5b9a\u3057\u3001\u305d\u308c\u304cCOVID-19\u306e\u91cd\u75c7\u5ea6\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8312547\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8312547\/<\/a><\/p>\n<p>\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001COVID-19\u5165\u9662\u60a3\u8005\u304c\u3075\u305f\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u3051\u3089\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u5165\u9662\u6642\u306b\u304a\u3051\u308b\u5168\u8840\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u306e\u4e3b\u6210\u5206\u89e3\u6790\u304b\u3089\u3001\u30b0\u30eb\u30fc\u30d7\uff11\uff08\u9752\uff09\u306f\u5065\u5e38\u8005\u306b\u8fd1\u304f\u3001\u30b0\u30eb\u30fc\u30d72\uff08\u8d64\uff09\u306f\u96e2\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/COVID-19_two-groups.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-5551\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/COVID-19_two-groups-300x189.png\" alt=\"\" width=\"300\" height=\"189\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/COVID-19_two-groups-300x189.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/COVID-19_two-groups-600x377.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/COVID-19_two-groups.png 728w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u30b0\u30eb\u30fc\u30d72\u306b\u304a\u3044\u3066\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306f\u3001\u9aa8\u9ac4\u7d30\u80de\u306e\u7279\u5fb4\u3001\u597d\u4e2d\u7403\u306e\u6d3b\u6027\u5ea6\u3001\u708e\u75c7\u5fdc\u7b54\u3001TLR\u3068Type I IFN\u306e\u30b7\u30b0\u30ca\u30eb\u30d1\u30b9\u3001T\u7d30\u80de\u5897\u6b96\u306e\u6291\u5236\uff08\u4f8b\u3048\u3070\u3001arginase 1\u3001PDL1\u3001PDL2\u3001CD276\/B7-H3\uff09\u3089\u306b\u5c5e\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u53cd\u5bfe\u306b\u3001CD8 \u3084 NK\u7d30\u80de\u6a5f\u80fd\u3001T\u7d30\u80de\u6d3b\u6027\u5316\u3001\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u5206\u5316\u3001\u5171\u523a\u6fc0\u53d7\u5bb9\u4f53\uff08TNFRSF4 (OX40)\u3001ICOSLG (ICOS ligand)\u3001TNFRSF18 (GITR)\u3001TNFRSF11A (RANK)\uff09\u3001\u305d\u3057\u3066\u6297\u539f\u63d0\u793a\u3089\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306f\u3001\u30b0\u30eb\u30fc\u30d72\u306b\u304a\u3044\u3066\u4f4e\u767a\u73fe\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u7570\u306a\u3063\u305f\u514d\u75ab\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6301\u3064\u60a3\u8005\u304c\u3044\u308b\u3053\u3068\u3068\u9069\u5408\u3057\u3066\u3044\u307e\u3059\u3001\u5373\u3061(i)\u7372\u5f97\u514d\u5f79\u30c8\u30ea\u30ac\u30fc\u306e\u30b0\u30eb\u30fc\u30d7\uff08group 1\uff09\u3068(ii)\u60aa\u5316\u3057\u305f\u9aa8\u9ac4\u7cfb\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u3068\u7372\u5f97\u514d\u5f79\u4e0d\u5168\uff08group 2\uff09\u3068\u3044\u3046\u8a33\u3067\u3059\u3002<\/p>\n<p>\u30b0\u30eb\u30fc\u30d72\u3068\u30b0\u30eb\u30fc\u30d71\u3067\u306f\u3001\u5e74\u9f62\u3084\u7cd6\u5c3f\u75c5\u306b\u304a\u3044\u3066\u5dee\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3001\u304c\u3001\u30b0\u30eb\u30fc\u30d72\u306e\u65b9\u304c\u80a5\u6e80\u5ea6\u306f\u30b0\u30eb\u30fc\u30d71\u3088\u308a\u3082\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002COVID-19\u306e\u91cd\u75c7\u5ea6\u306e\u57fa\u6e96\u306fWHO\u306e\u5b9a\u3081\u305f\u305d\u308c\u306b\u5f93\u3063\u3066\u3044\u307e\u3059\u3001\u8efd\u75c7\u304c4-5 WHO score\u3068\u306a\u308a\u3001\u91cd\u75c7\u304c &gt;6 WHO score\u3068\u306a\u308a\u307e\u3059\u3002\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001\u30b0\u30eb\u30fc\u30d72\u306e\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u60a3\u8005\uff0894%\uff09\u306f\u3001WHO score\u304c6\u4ee5\u4e0a\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u305d\u308c\u306b\u6bd4\u3079\u3066\u30b0\u30eb\u30fc\u30d71\u306e\u540c\u6bd4\u7387\u306f25%\u306b\u3057\u304b\u3059\u304e\u307e\u305b\u3093\u3002\u3075\u305f\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u9593\u3067\u898b\u3089\u308c\u308b\u305d\u306e\u4ed6\u306e\u91cd\u8981\u306a\u5668\u5b98\u3084\u7d44\u7e54\uff08\u4f8b\u3048\u3070\u3001\u809d\u81d3\u3001\u814e\u81d3\u3001\u5fc3\u81d3\u3001\u8840\u7ba1\uff09\u306b\u304a\u3051\u308b\u751f\u7269\u5b66\u7684\u306a\u6307\u6a19\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u809d\u81d3\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u53cd\u6620\u3059\u308b\u8102\u80aa\u809d\u6307\u6a19 (HSI)\u3084\u30d7\u30ed\u30c8\u30ed\u30f3\u30d3\u30f3\u6bd4 (% PR)\u3001\u814e\u81d3\u969c\u5bb3\u3092\u53cd\u6620\u3059\u308b\u5c3f\u4e2d Na+\u3084Na+\/K+\u6bd4\u3001\u5faa\u74b0\u5668\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u534a\u5186\u3059\u308b\u30c8\u30ed\u30dd\u30cb\u30f3\u3001\u8840\u7ba1\u5185\u76ae\u306e\u72b6\u614b\u3092\u53cd\u6620\u3059\u308bE-\u30bb\u30ec\u30af\u30c1\u30f3\u3084\u80ce\u76e4\u5897\u6b96\u56e0\u5b50 (PlGF)\u3089\u304c\u3001\u30b0\u30eb\u30fc\u30d72\u306b\u304a\u3044\u3066\u9855\u8457\u306b\u30b0\u30eb\u30fc\u30d71\u3068\u306f\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u5305\u62ec\u7684\u306b\u8a00\u3048\u3070\u3001\u591a\u81d3\u5668\u4e0d\u5168\u3001\u8840\u7ba1\u5185\u76ae\u306e\u30c0\u30e1\u30fc\u30b8\u3084\u8840\u6813\u75c7\u304c\u30b0\u30eb\u30fc\u30d72\u306e\u60a3\u8005\u3067\u969b\u7acb\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u4e8b\u304c\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u6b7b\u8005\u306e88%\u306f\u30b0\u30eb\u30fc\u30d72\u306b\u5c5e\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3082\u3001\u30b0\u30eb\u30fc\u30d7\u9593\u306e\u514d\u75ab\u5fdc\u7b54\u306e\u9055\u3044\u304c\u9855\u8457\u306a\u7d50\u679c\u306e\u9055\u3044\u3068\u3057\u3066\u73fe\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3075\u305f\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u9593\u306e\u514d\u75ab\u7d30\u80de\u6570\u306e\u9055\u3044\u306b\u3064\u3044\u3066\u306f\u3001\u30b0\u30eb\u30fc\u30d72\u306e\u7279\u5fb4\u306f\u3001\u767d\u8840\u7403\u306e\u5897\u52a0\u3001\u9855\u8457\u306a\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u75c7\u3001CD8<sup>+<\/sup> T\u7d30\u80de\u306e\u6e1b\u5c11\u3001CD4<sup>+<\/sup> T\u7d30\u80de\u306e\u5897\u52a0\u3001NK\u7d30\u80de\u306e\u6e1b\u5c11\u3001\u597d\u4e2d\u7403\u306e\u5897\u52a0\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u3067\u3042\u308a\u307e\u3059\u3002\u52a0\u3048\u3066\u3001\u30b0\u30eb\u30fc\u30d72\u306b\u304a\u3044\u3066\u306f\u3001\u8840\u4e2d\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-6\u3001IL-8\u3001TNF-\u03b1\u3001\u53ef\u6eb6\u6027TNF\u53d7\u5bb9\u4f532\uff09\u3089\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001\u30b0\u30eb\u30fc\u30d72\u306b\u304a\u3044\u3066\u708e\u75c7\u53cd\u5fdc\u3084\u597d\u4e2d\u7403\u53cd\u5fdc\u304c\u9ad8\u304f\u3001NK\u7d30\u80de\u3084T\u7d30\u80de\u5fdc\u7b54\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u3001\u30b0\u30eb\u30fc\u30d71\u306b\u304a\u3044\u3066\u306f\u3088\u308a\u7372\u5f97\u514d\u5f79\u53cd\u5fdc\u3092\u597d\u3080\u3088\u3046\u306a\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u3066\u3044\u307e\u3059\u3002\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001\u30b0\u30eb\u30fc\u30d72\u306b\u304a\u3044\u3066\u306f\u3001PMBC\u306eTLR3\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sorbonne 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class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-5544","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5544"}],"version-history":[{"count":12,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5544\/revisions"}],"predecessor-version":[{"id":5573,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5544\/revisions\/5573"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}