{"id":5529,"date":"2021-08-05T13:11:24","date_gmt":"2021-08-05T04:11:24","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5529"},"modified":"2021-08-05T13:11:24","modified_gmt":"2021-08-05T04:11:24","slug":"sars-cov-2%e3%81%ae%e5%a4%89%e7%95%b0%e6%a0%aa%ef%bc%88%e3%82%a2%e3%83%ab%e3%83%95%e3%82%a1%e3%80%81%e3%83%99%e3%83%bc%e3%82%bf%e3%80%81%e3%82%ac%e3%83%b3%e3%83%9e%e3%80%81%e3%83%87%e3%83%ab%e3%82%bf","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e5%a4%89%e7%95%b0%e6%a0%aa%ef%bc%88%e3%82%a2%e3%83%ab%e3%83%95%e3%82%a1%e3%80%81%e3%83%99%e3%83%bc%e3%82%bf%e3%80%81%e3%82%ac%e3%83%b3%e3%83%9e%e3%80%81%e3%83%87%e3%83%ab%e3%82%bf\/","title":{"rendered":"SARS-CoV-2\u306e\u5909\u7570\u682a\uff08\u30a2\u30eb\u30d5\u30a1\u3001\u30d9\u30fc\u30bf\u3001\u30ac\u30f3\u30de\u3001\u30c7\u30eb\u30bf\u3001\u30a4\u30d7\u30b7\u30ed\u30f3\u3001\u30ab\u30c3\u30d1\uff09\u3068ACE2\u306e\u7d50\u5408\u529b\u306e\u5206\u5b50\u52d5\u529b\u5b66\u7684\u306a\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u304b\u3089"},"content":{"rendered":"

Lehigh University, Bethlehem, USA\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u5404\u7a2e\u5909\u7570\u682a\u306eRBD\u3068ACE2\u306e\u9593\u306e\u7d50\u5408\u529b\u306b\u3064\u3044\u3066\u3001\u7cd6\u9396\u4fee\u98fe\u3082\u8003\u616e\u306b\u5165\u308c\u305f\u5f62\u3067\u5206\u5b50\u52d5\u529b\u5b66\u30b7\u30e5\u30df\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8328061\/<\/a><\/p>\n

SARS-CoV-2 RBD\u3068ACE2\u8907\u5408\u4f53\u306b\u5bfe\u3057\u3066\u3001RBD\u3068ACE2\u305d\u308c\u305e\u308c\u306e\u91cd\u5fc3\u9593\u306e\u8ddd\u96e2\u306e\u95a2\u6570\u3068\u3057\u3066\u5f15\u304d\u5265\u304c\u3059\u306b\u5fc5\u8981\u306a\u5f15\u3063\u5f35\u308a\u529b\u3092\u5206\u5b50\u52d5\u529b\u5b66\u30b7\u30e5\u30df\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u308a\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002RBD-ACE2\u8907\u5408\u4f53\u306b\u3064\u3044\u3066\u306f\u3001N\u578b\u7cd6\u9396\u306e\u5b8c\u5168\u4fee\u98fe\u3092\u4eee\u5b9a\u3057\u3001\u4e0b\u8a18\u306e6\u7a2e\u306eSARS-CoV-2\u5909\u7570\u682a\u306b\u3064\u3044\u3066\u8a08\u7b97\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u30a2\u30eb\u30d5\u30a1\u5909\u7570\u682a (\u82f1\u56fd\u306b\u304a\u3044\u3066\u767a\u898b, B.1.1.7: N501Y),
\n\u30d9\u30fc\u30bf\u5909\u7570\u682a (\u5357\u30a2\u30d5\u30ea\u30ab\u306b\u304a\u3044\u3066\u767a\u898b, B.1.351: K417N, E484K, N501Y),
\n\u30ac\u30f3\u30de\u5909\u7570\u682a (\u65e5\u672c\u3068\u30d6\u30e9\u30b8\u30eb\u306b\u304a\u3044\u3066\u767a\u898b, P.1: K417T, E484K, N501Y),
\n\u30c7\u30eb\u30bf\u5909\u7570\u682a (\u30a4\u30f3\u30c9\u306b\u304a\u3044\u3066\u767a\u898b, B.1.617.2: L452R, T478K)),
\n\u30a4\u30d7\u30b7\u30ed\u30f3\u5909\u7570\u682a (\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u306b\u304a\u3044\u3066\u767a\u898b, B.1.427: L452R) ,
\n\u30ab\u30c3\u30d1\u5909\u7570\u682a (\u30a4\u30f3\u30c9\u306b\u304a\u3044\u3066\u767a\u898b, B.1.617.1: L452R, E484Q)),<\/p>\n

\u30a2\u30eb\u30d5\u30a1\u5909\u7570\u682a\u304c\u3001ACE2\u304b\u3089\u306e\u5f15\u304d\u96e2\u3057\u306b\u306f\u4e00\u756a\u5f37\u3044\u529b\u3092\u5fc5\u8981\u3068\u3057\u3001\u30d9\u30fc\u30bf\u5909\u7570\u682a\u3001\u30ac\u30f3\u30de\u5909\u7570\u682a\u6216\u3044\u306f\u30c7\u30eb\u30bf\u5909\u7570\u682a\u306e\u9806\u306b\u306a\u308a\u307e\u3059\u3002\u30d9\u30fc\u30bf\u5909\u7570\u682a\u3068\u30ac\u30f3\u30de\u5909\u7570\u682a\u306eK417N\/T\u5909\u7570\u304c\u3001\u30a2\u30eb\u30d5\u30a1\u5909\u7570\u682a\u306b\u6bd4\u3079\u3066\u529b\u304c\u5f31\u304f\u306a\u3063\u3066\u3044\u308b\u539f\u56e0\u306e\u3088\u3046\u3067\u3059\u3002\u52a0\u3048\u3066\u3001\u30a4\u30d7\u30b7\u30ed\u30f3\u5909\u7570\u682a\u306fL452R\u5909\u7570\u306b\u3088\u3063\u3066\u4e0d\u5b89\u5b9a\u5316\u3057\u305fRBD\u306e\u69cb\u9020\u306b\u3088\u308a\u4ed6\u306e\u5909\u7570\u682a\u3088\u308a\u3082\u529b\u304c\u5f31\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u30c7\u30eb\u30bf\u5909\u7570\u682a\u306f\u3001RBD\u3068ACE2\u306e\u8ddd\u96e2\u304c\u76f8\u5bfe\u7684\u306b\u9060\u3044\u5834\u5408\u306b\u6700\u3082\u5f37\u3044\u529b\u3092\u5fc5\u8981\u3068\u3059\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30c7\u30eb\u30bf\u5909\u7570\u682a\u306e\u69d8\u5b50\u306f\u3001\u4ed6\u306e\u5909\u7570\u682a\u3068\u306f\u9055\u3063\u3066\u3044\u307e\u3059\u3002T478K\u5909\u7570\u306e\u5f71\u97ff\u306b\u3066\u3001RBD-ACE2\u9593\u306e\u8ddd\u96e2\u304c78\u212b\u3067\u5b8c\u5168\u306b\u5206\u96e2\u3059\u308b\u3068\u304d\u306b\u6700\u3082\u5f37\u3044\u529b\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002\u4f55\u304c\u305d\u306e\u9055\u3044\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u308b\u304b\u306a\u306e\u3067\u3059\u304c\u3001T478K\u5909\u7570\u306b\u3088\u3063\u3066\u3001\u30c7\u30eb\u30bf\u5909\u7570\u682a\u306eRBD\u3068ACE2b\u306e\u9593\u306b\u306f\u4ed6\u306e\u5909\u7570\u682a\u306e\u5834\u5408\u3088\u308a\u3082\u3088\u308a\u591a\u304f\u306e\u5206\u5b50\u9593\u7d50\u5408\u70b9\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u3002\u30c7\u30eb\u30bf\u5909\u7570\u682a\u306eK487\u306f\u3001\u8ddd\u96e2=78\u212b\u306b\u304a\u3044\u3066ACE2\u306eP84\u3068M82\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u304c\u3001\u30a4\u30d7\u30b7\u30ed\u30f3\u5909\u7570\u682a\u306eT478\u3067\u306f\u3053\u306e\u3088\u3046\u306a\u76f8\u4e92\u4f5c\u7528\u306f\u6d88\u5931\u3057\u3066\u3044\u307e\u3059\u3002\u30d5\u30ec\u30ad\u30b7\u30d6\u30eb\u306a\u30eb\u30fc\u30d7\u306b\u5b58\u5728\u3059\u308b478\u6b8b\u57fa\u304cACE2\u3068\u4e00\u756a\u6700\u521d\u306b\u7d50\u5408\u3059\u308b\u30c1\u30e3\u30f3\u30b9\u304c\u3042\u308a\u3001\u305d\u306e\u9593\u306e\u5f37\u3044\u76f8\u4e92\u4f5c\u7528\u304c\u30c7\u30eb\u30bf\u5909\u7570\u682a\u304c\u305d\u306e\u9ad8\u3044\u611f\u67d3\u529b\u3067\u8513\u5ef6\u3057\u305f\u539f\u56e0\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Lehigh University, Bethlehem, USA\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u306e\u5404\u7a2e\u5909\u7570\u682a\u306eRBD\u3068ACE2\u306e\u9593\u306e\u7d50\u5408\u529b\u306b\u3064\u3044\u3066\u3001\u7cd6\u9396\u4fee\u98fe\u3082\u8003\u616e\u306b\u5165\u308c\u305f\u5f62\u3067\u5206\u5b50\u52d5\u529b\u5b66\u30b7\u30e5\u30df\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-5529","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5529"}],"version-history":[{"count":8,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5529\/revisions"}],"predecessor-version":[{"id":5538,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5529\/revisions\/5538"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}