{"id":5523,"date":"2021-08-04T16:34:14","date_gmt":"2021-08-04T07:34:14","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5523"},"modified":"2021-08-04T16:35:15","modified_gmt":"2021-08-04T07:35:15","slug":"about-importance-of-lectin-complement-pathway-on-severe-covid-19-pathology","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/about-importance-of-lectin-complement-pathway-on-severe-covid-19-pathology\/","title":{"rendered":"About importance of lectin complement pathway on severe COVID-19 pathology"},"content":{"rendered":"

A group from University of Cambridge, Cambridge, United Kingdom, etc. has reported on importance of lectin complement pathway on severe COVID-19 pathology.
\nhttps:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.714511\/full<\/a><\/p>\n

The complement system is an integral part of the innate and the adaptive immune systems, and three pathways are known: Classical pathway, Alternative pathway, and Lectin pathway.
\nThe mannan-binding lectin-associated serine protease-2 (MASP-2) is the key enzyme of the Lectin pathway. The activated MASP-2 can cleave C4 efficiently to form C3 and C5 convertase complexes C4bC2a and C4bC2aC3b, leading to the formation of membrane attack complex (MAC). The pathogen-associated molecular patterns (PAMPs) recognition subcomponents (LP recognition molecules) are the key to activate MAPS-2. Those in humans are mannose-binding lectin (MBL), collectin-11 (CL-11), and heterocomplexes of CL-11 and CL-10 and ficolin. The Lectin pathway is initiated by the complexes of LP recognition subcomponent and MAPS-2 bind to PAMPs.<\/p>\n

Binding of LP recognition molecules to SARS-CoV-2 proteins was studied. A MTP ELISA plate was coated with either SARS-CoV-2 Spike, SARS-CoV-2 N protein or control ligands (mannan for MBL, N-acetyl BSA for ficolin 2(FCN2), zymosan for CL-11), and serial dilutions of serum were added to the wells. It is clearly shown that LP recognition molecules such as MBL, ficolin2, and CL-11 bind to SARS-CoV-2 Proteins.<\/p>\n

\"\"<\/a><\/p>\n

Although it was not mentioned if the LP was associated with COVID-19 severity in this report, this might be one of causes leading to acute respiratory distress syndrome (ARDS).<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from University of Cambridge, Cambridge, United Kingdom, etc. has reported on importance of lectin com<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-5523","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5523"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5523\/revisions"}],"predecessor-version":[{"id":5524,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5523\/revisions\/5524"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}