{"id":5513,"date":"2021-08-04T16:34:14","date_gmt":"2021-08-04T07:34:14","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5513"},"modified":"2021-08-04T16:34:14","modified_gmt":"2021-08-04T07:34:14","slug":"sars-cov-2-spike%e3%81%af%e3%80%81%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e6%8d%95%e4%bd%93%e7%b3%bb%e8%b7%af%e3%82%92%e6%b4%bb%e6%80%a7%e5%8c%96%e3%81%a7%e3%81%8d%e3%82%8b","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2-spike%e3%81%af%e3%80%81%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e6%8d%95%e4%bd%93%e7%b3%bb%e8%b7%af%e3%82%92%e6%b4%bb%e6%80%a7%e5%8c%96%e3%81%a7%e3%81%8d%e3%82%8b\/","title":{"rendered":"SARS-CoV-2 Spike\u306f\u3001\u30ec\u30af\u30c1\u30f3\u6355\u4f53\u7cfb\u8def\u3092\u6d3b\u6027\u5316\u3067\u304d\u308b"},"content":{"rendered":"<p>University of Cambridge, Cambridge, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306e\u91cd\u75c7\u5316\u75c5\u7406\u306b\u304a\u3051\u308b\u30ec\u30af\u30c1\u30f3\u6355\u4f53\u7cfb\u8def\u306e\u91cd\u8981\u6027\u306b\u3064\u3044\u3066\u8a00\u53ca\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.714511\/full\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.714511\/full<\/a><\/p>\n<p>\u88dc\u4f53\u7d4c\u8def\u306f\u3001\u81ea\u7136\u514d\u75ab\u53ca\u3073\u7372\u5f97\u514d\u75ab\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u514d\u75ab\u6a5f\u69cb\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u73fe\u5728\u307e\u3067\u306b\u4e09\u7a2e\u306e\u6355\u4f53\u7cfb\u8def\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3001\u53e4\u5178\u7d4c\u8def\u3001\u4ee3\u66ff\u7d4c\u8def\u3001\u305d\u3057\u3066\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u3067\u3059\u3002<br \/>\nmannan-binding lectin-associated serine protease-2 (MASP-2) \u304c\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u306b\u304a\u3051\u308b\u30ad\u30fc\u3068\u306a\u308b\u9175\u7d20\u3067\u3059\u3002\u6d3b\u6027\u5316\u3055\u308c\u305f MASP-2 \u304c C4 \u3092\u52b9\u679c\u7684\u306b\u5207\u65ad\u3067\u304d\u3001C3 \u53ca\u3073 C5 \u8ee2\u63db\u9175\u7d20\u8907\u5408\u4f53 C4bC2a \u53ca\u3073 C4bC2aC3b\u3092\u4f5c\u308b\u3053\u3068\u304c\u51fa\u6765\u3001\u9806\u6b21\u6d3b\u6027\u5316\u3057\u3066\u3001\u6700\u7d42\u7684\u306a\u7d30\u80de\u819c\u4fb5\u8972\u8907\u5408\u4f53\u3092\u4f5c\u308a\u307e\u3059\u3002pathogen-associated molecular patterns (PAMPs) \u8a8d\u8b58\u5206\u5b50\u304cMAPS-2\u3092\u6d3b\u6027\u5316\u3059\u308b\u306b\u306f\u30ad\u30fc\u3068\u306a\u308a\u307e\u3059\u3002\u30d2\u30c8\u306b\u304a\u3051\u308bPAMPs\u8a8d\u8b58\u5206\u5b50\u306b\u306f\u3001mannose-binding lectin (MBL)\u3001collectin-11 (CL-11)\u3001\u305d\u3057\u3066CL-11 \u3068 CL-10 \u3068 ficolin\u306e\u30d8\u30c6\u30ed\u7d50\u5408\u5206\u5b50\u304c\u3042\u308a\u307e\u3059\u3002\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u306f\u3001\u3053\u306ePAMPs\u8a8d\u8b58\u5206\u5b50\u304c\u75c5\u539f\u83cc\u306ePAMPs\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u958b\u59cb\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>SARS-CoV-2\u306eSpike\u30bf\u30f3\u30d1\u30af\u8cea\u3084N\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3059\u308b\u3053\u308c\u3089PAMPs\u8a8d\u8b58\u5206\u5b50\u306e\u7d50\u5408\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002ELISA MTP\u306bSARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea, SARS-CoV-2 N\u30bf\u30f3\u30d1\u30af\u8cea \u6216\u3044\u306f\u307e\u305f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30ea\u30ac\u30f3\u30c9\uff08mannan \u3092 MBL\u306b\u3001N-acetyl BSA \u3092 ficolin 2(FCN2)\u306b\u3001zymosan \u3092 CL-11\u306b\uff09\u56fa\u5b9a\u5316\u3057\u3001\u8840\u6e05\u306e\u5e0c\u91c8\u7cfb\u5217\u3092Well\u306b\u30a2\u30d7\u30e9\u30a4\u3057\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306b\u793a\u3059\u3088\u3046\u306b\u3001PAMPs\u8a8d\u8b58\u5206\u5b50\uff08MBL\u3001ficolin2\u3001CL-11\uff09\u304cSARS-CoV-2\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u660e\u78ba\u306b\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/lectin-pathway_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/lectin-pathway_SARS-CoV-2-1024x344.png\" alt=\"\" width=\"696\" height=\"234\" class=\"alignnone size-large wp-image-5514\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/lectin-pathway_SARS-CoV-2-1024x344.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/lectin-pathway_SARS-CoV-2-600x202.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/lectin-pathway_SARS-CoV-2-300x101.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/lectin-pathway_SARS-CoV-2-768x258.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/08\/lectin-pathway_SARS-CoV-2.png 1192w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" \/><\/a><\/p>\n<p>\u3053\u306e\u30ec\u30dd\u30fc\u30c8\u306b\u304a\u3044\u3066\u306f\u3001\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u304cCOVID-19\u306e\u91cd\u75c7\u5316\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306f\u30c7\u30fc\u30bf\u306f\u793a\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u3053\u308c\u304c\u3001\u6025\u6027\u547c\u5438\u7aae\u8feb\u75c7\u5019\u7fa4\uff08ARDS\uff09\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u306f\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Cambridge, Cambridge, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306e\u91cd\u75c7\u5316\u75c5\u7406\u306b\u304a\u3051\u308b\u30ec\u30af\u30c1\u30f3\u6355\u4f53\u7cfb\u8def\u306e\u91cd\u8981\u6027\u306b\u3064\u3044\u3066\u8a00\u53ca\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.frontiers<\/p><\/div>\n<div 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class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-5513","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5513"}],"version-history":[{"count":8,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5513\/revisions"}],"predecessor-version":[{"id":5522,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5513\/revisions\/5522"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}