{"id":5422,"date":"2021-08-01T06:00:53","date_gmt":"2021-07-31T21:00:53","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5422"},"modified":"2021-07-30T08:55:25","modified_gmt":"2021-07-29T23:55:25","slug":"effectiveness-of-tocilizumab-and-dexamethasone-in-covid-19-severe-patients","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/effectiveness-of-tocilizumab-and-dexamethasone-in-covid-19-severe-patients\/","title":{"rendered":"Effectiveness of Tocilizumab and Dexamethasone in COVID-19 severe patients"},"content":{"rendered":"<p>A group from Jan Kochanowski University, Kielce, Poland, etc. has reported effectiveness of Tocilizumab and Dexamethasone in COVID-19 severe patients.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8291861\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8291861\/<\/a><\/p>\n<p>Comparing four groups (treated with Tocilizmab (TCZ), treated with TCZ and Dexamethason (DEX), treated with DEX, and no TCZ nor DEX), the death rate of 6.8% was significantly lower in patients receiving TCZ alone than other groups (19.6%\u201323.1%), particularly in patients with IL-6 concentration exceeding 100pg\/mL, the death rate was significantly lower in patients receiving TCZ alone than other groups (5% vs 22.9%\u201351.7%, respectively).<br \/>\nThe clinical improvements on day21 and day28 were also doubled in the case of TCZ alone (60% and 75%, respectively)comparing with that in that case of DEX alone (27.6% and 37.9%, respectively). <\/p>\n<p>So, in patients with severe course of COVID-19, particularly those developing cytokine storm, administration of TCZ provides a significantly better effect than DEX regarding survival, clinical improvement, and hospital discharge rate. The combination of TCZ and DEX does not improve therapy effectiveness in patients with severe COVID-19 compared to the administration of TCZ alone.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Jan Kochanowski University, Kielce, Poland, etc. has reported effectiveness of Tocilizumab and De<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/effectiveness-of-tocilizumab-and-dexamethasone-in-covid-19-severe-patients\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-5422","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5422"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5422\/revisions"}],"predecessor-version":[{"id":5423,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5422\/revisions\/5423"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5422"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5422"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}