{"id":5367,"date":"2021-08-01T06:30:26","date_gmt":"2021-07-31T21:30:26","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5367"},"modified":"2021-07-30T12:54:35","modified_gmt":"2021-07-30T03:54:35","slug":"%e8%82%9d%e9%a1%9e%e6%b4%9e%e5%a3%81%e5%86%85%e7%9a%ae%e7%b4%b0%e8%83%9e%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6%e3%81%af%e3%80%81l-sign%e3%81%8csars-cov-2%e3%81%ae%e6%ad%a3%e5%bd%93%e3%81%aa%e6%84%9f","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e8%82%9d%e9%a1%9e%e6%b4%9e%e5%a3%81%e5%86%85%e7%9a%ae%e7%b4%b0%e8%83%9e%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6%e3%81%af%e3%80%81l-sign%e3%81%8csars-cov-2%e3%81%ae%e6%ad%a3%e5%bd%93%e3%81%aa%e6%84%9f\/","title":{"rendered":"\u809d\u985e\u6d1e\u58c1\u5185\u76ae\u7d30\u80de\u306b\u304a\u3044\u3066\u306f\u3001L-SIGN\u304cSARS-CoV-2\u306e\u6b63\u5f53\u306a\u611f\u67d3\u53d7\u5bb9\u4f53\u3067\u3042\u308b"},"content":{"rendered":"<p>Oklahoma Medical Research Foundation, Oklahoma, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001L-SIGN\u304cSARS-CoV-2\u611f\u67d3\u306e\u6b63\u5f53\u306a\u611f\u67d3\u53d7\u5bb9\u4f53\u3067\u3042\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/insight.jci.org\/articles\/view\/148999\">https:\/\/insight.jci.org\/articles\/view\/148999<\/a><\/p>\n<p>L-SIGN\u304cSARS-CoV-2\u3068\u76f8\u4e92\u4f5c\u7528\u3092\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3059\u308b\u70ba\u306b\u3001SARS-C-V-2\u306e\u7591\u4f3c\u30a6\u30a4\u30eb\u30b9\u3068L-SIGN\u304a\u3088\u3073ACE2\u3092\u767a\u73fe\u3059\u308bHEK293T\u7d30\u80de\u3092\u7528\u610f\u3057\u307e\u3057\u305f\u3002L-SIGN \u306f\u3054\u5b58\u77e5\u306e\u3088\u3046\u306bC-\u578b\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308a\u3001high mannose\u578b\u306eN-\u578b\u7cd6\u9396\u306bCa<sup>2+<\/sup>\u306b\u4f9d\u5b58\u3057\u305f\u7d50\u5408\u3092\u793a\u3057\u307e\u3059\u3002SARS-CoV-2 RBD\u306b\u306fAsn343\u306bN-\u578b\u7cd6\u9396\u306e\u4fee\u98fe\u30b5\u30a4\u30c8\u304c\u3042\u308a\u307e\u3059\u3002Asn343\u3092glutamine (Q)\u3067\u7f6e\u63db\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001N-\u578b\u7cd6\u9396\u304c\u6b20\u640d\u3057\u305fspike\/Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08SpikeN343Q\/Fc\uff09\u3092\u4f5c\u308a\u3001WT\uff08Spike\/Fc\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3059\u3002SpikeN343Q\/Fc\u306b\u304a\u3044\u3066mannose\u69cb\u9020\u304c\u6b20\u640d\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u3001GNL\u30ec\u30af\u30c1\u30f3\u30d6\u30ed\u30c3\u30c8\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u3001SpikeN343Q\/Fc \u306f\u3001ACE2\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u7d30\u80de\u306b\u306f\u7d50\u5408\u3059\u308b\u304c\u3001L-SIGN\u3092\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\u7d30\u80de\u306b\u306f\u7d50\u5408\u3057\u306a\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3001L-SIGN\u306f\u3001SARS-CoV-2 RBD\u306eAsn343\u306b\u5b58\u5728\u3059\u308b\u7cd6\u9396\u3092\u8a8d\u8b58\u3057\u3066\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/L-SIGN_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/L-SIGN_SARS-CoV-2.png\" alt=\"\" width=\"716\" height=\"141\" class=\"alignnone size-full wp-image-5436\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/L-SIGN_SARS-CoV-2.png 716w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/L-SIGN_SARS-CoV-2-600x118.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/L-SIGN_SARS-CoV-2-300x59.png 300w\" sizes=\"auto, (max-width: 716px) 100vw, 716px\" \/><\/a><\/p>\n<p>\u30d2\u30c8\u306e\u809d\u985e\u6d1e\u58c1\u5185\u76ae\u7d30\u80de\uff08LSEC\uff53\uff09\u306b\u306f\u3001L-SIGN\u306f\u767a\u73fe\u3057\u3066\u3044\u308b\u304c\u3001ACE2\u306f\u5168\u304f\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002SARS-CoV-2\u3068L-SIGN\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u6301\u3064\u81e8\u5e8a\u7684\u306a\u610f\u5473\u3092\u660e\u78ba\u306b\u3059\u308b\u305f\u3081\u306b\u3001COVID-19\u306e\u30db\u30eb\u30de\u30ea\u30f3\u56fa\u5b9a\u30d1\u30e9\u30d5\u30a3\u30f3\u30a8\u30f3\u30d9\u306e\u809d\u81d3\u691c\u6b7b\u30b5\u30f3\u30d7\u30eb\u3092\u7528\u3044\u3066\u3001SARS-CoV-2\u306e\u611f\u67d3\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002SARS-CoV-2\u306b\u611f\u67d3\u3057\u3066\u3044\u306a\u3044\u540c\u69d8\u306a\u691c\u6b7b\u30b5\u30f3\u30d7\u30eb\u3068\u306e\u6bd4\u8f03\u306b\u304a\u3044\u3066\u3001\u3053\u306e\u3053\u3068\u304c\u660e\u78ba\u306b\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08LSECs\u306b\u306f\u3001L-SIGN \u304c\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\uff08\u7dd1\u8272\u3067\u793a\u3059\uff09\u3001\u305d\u3057\u3066\u8d64\u306e\u77e2\u5370\u306fSARS-CoV-2\u304c\u611f\u67d3\u3057\u3066\u3044\u308b\u7b87\u6240\u3092\u6307\u3057\u793a\u3059\u3082\u306e\u3067\u3059\uff09\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/LSEC_L-SIGN_SARS-CoV-2.png\"><img decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/LSEC_L-SIGN_SARS-CoV-2.png\" alt=\"\" width=\"300\" class=\"alignnone size-full wp-image-5438\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/LSEC_L-SIGN_SARS-CoV-2.png 494w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/LSEC_L-SIGN_SARS-CoV-2-300x131.png 300w\" sizes=\"(max-width: 494px) 100vw, 494px\" \/><\/a><\/p>\n<p>\u52a0\u3048\u3066\u3001\u3053\u306eSARS-CoV-2\u306e\u611f\u67d3\u306f\u3001\u30d2\u30c8\u306eL-SIGN\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3001\u305d\u3057\u3066\u307e\u305fmannan\u3067\u30c9\u30fc\u30ba\u4f9d\u5b58\u7684\u306b\u963b\u5bb3\u3055\u308c\u3001\u3053\u308c\u3089\u304cCOVID-19\u611f\u67d3\u306e\u91cd\u75c7\u5316\u3092\u6291\u3048\u308b\u305f\u3081\u306e\u6cbb\u7642\u85ac\u3068\u306a\u308a\u5f97\u308b\u53ef\u80fd\u6027\u3082\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002 <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oklahoma Medical Research Foundation, Oklahoma, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001L-SIGN\u304cSARS-CoV-2\u611f\u67d3\u306e\u6b63\u5f53\u306a\u611f\u67d3\u53d7\u5bb9\u4f53\u3067\u3042\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/in<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e8%82%9d%e9%a1%9e%e6%b4%9e%e5%a3%81%e5%86%85%e7%9a%ae%e7%b4%b0%e8%83%9e%e3%81%ab%e3%81%8a%e3%81%84%e3%81%a6%e3%81%af%e3%80%81l-sign%e3%81%8csars-cov-2%e3%81%ae%e6%ad%a3%e5%bd%93%e3%81%aa%e6%84%9f\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-5367","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5367"}],"version-history":[{"count":27,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5367\/revisions"}],"predecessor-version":[{"id":5451,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5367\/revisions\/5451"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}