{"id":5245,"date":"2021-07-22T17:13:17","date_gmt":"2021-07-22T08:13:17","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5245"},"modified":"2021-07-22T17:15:09","modified_gmt":"2021-07-22T08:15:09","slug":"inhibition-of-sars-cov-2-infection-with-seaweed-polysaccharides-and-those-cytotoxicity","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/inhibition-of-sars-cov-2-infection-with-seaweed-polysaccharides-and-those-cytotoxicity\/","title":{"rendered":"Inhibition of SARS-CoV-2 infection with seaweed polysaccharides and those cytotoxicity"},"content":{"rendered":"

A group from Marine Biotechnology Research Center, Korea, etc. has reported on inhibition of SARS-CoV-2 infection with seaweed polysaccharides and those cytotoxicity.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8071526\/<\/a><\/p>\n

Seaweeds are an excellent source of bioactive compounds such as polysaccharides, dietary fibers, amino acids, essential fatty acids, carotenoids, phlorotannins, vitamins, and minerals. These compounds have been reported to have a variety of pharmacological activities such as antitumor, antiviral, antioxidant, antimicrobial, anticoagulant, and immune-inflammatory effects<\/p>\n

Authers investigated the inhibitory activities of the following crude polysaccharides (CPs):
\nUndaria pinnatifida sporophyll (CPUP),
\nLaminaria japonica (CPLJ),
\nHizikia fusiforme (CPHF),
\nSargassum horneri (CPSH),
\nAbalone viscera (CPAV),
\nCodium fragile (CPCF),
\nPorphyra tenera (CPPT), and
\nFucoidan.<\/p>\n

Cytotoxicity Assay with the viability of HEK293\/ACE2 cells was assessed. When the HEK293\/ACE2 cells were treated with each CP at the final concentration range from 1 ng\/mL to 1 mg\/mL (serial diluted 1\/10) for 96 h, most of the CPs did not show severe cytotoxicity. However, CPAV, CPCF, and CPPT were slightly cytotoxic at a concentration of 1 mg\/mL. CPAV showed notable cytotoxicity when applied at a concentration of 1 mg\/mL, following a degree of cytotoxicity by CPPT, CPCF, CPHF, CPLJ, CPUP, CPSH, and fucoidan. Nevertheless, the CC50<\/sub> of all CPs was over 500 \u03bcg\/mL. <\/p>\n

The testing of the inhibition of viral infection by CPs was performed with a SARS-CoV-2 pseudovirus. All CPs, except CPPT, inhibited SARS-CoV-2 pseudovirus infection of HEK293\/ACE2 cells at various concentrations. Among the CPs tested, CPSH showed the strongest antiviral activity with an IC50<\/sub> of 12 \u03bcg\/mL, followed by CPAV (33 \u03bcg\/mL), CPHF (47 \u03bcg\/mL), CPCF (74 \u03bcg\/mL), CPLJ (105 \u03bcg\/mL), fucoidan (142 \u03bcg\/mL), and CPUP (289 \u03bcg\/mL), respectively.<\/p>\n

As a conclusion, Sargassum horneri (CPSH) would be the best as an anti-SARS-CoV-2 agent.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Marine Biotechnology Research Center, Korea, etc. has reported on inhibition of SARS-CoV-2 infect<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-5245","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t