{"id":5196,"date":"2021-07-22T09:47:19","date_gmt":"2021-07-22T00:47:19","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5196"},"modified":"2022-02-08T19:44:18","modified_gmt":"2022-02-08T10:44:18","slug":"%e3%83%ac%e3%83%b3%e3%82%ba%e8%b1%86%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%8csars-cov-2%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%ab%e5%af%be%e3%81%97%e3%81%a6%e5%ba%83%e7%af%84%e3%81%aa%e6%8a%97%e3%82%a6","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%83%ac%e3%83%b3%e3%82%ba%e8%b1%86%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%81%8csars-cov-2%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%ab%e5%af%be%e3%81%97%e3%81%a6%e5%ba%83%e7%af%84%e3%81%aa%e6%8a%97%e3%82%a6\/","title":{"rendered":"\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u304cSARS-CoV-2\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u5e83\u7bc4\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3059"},"content":{"rendered":"

National Institutes for Food and Drug Control (NIFDC), Beijing, China, \u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u304c\u3001SARS-CoV-2\u306e\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u3082\u6709\u671b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.tandfonline.com\/doi\/full\/10.1080\/22221751.2021.1957720<\/a><\/p>\n

Huh7\u7d30\u80de\u3068\u3042\u3089\u304b\u3058\u3081\u30ec\u30af\u30c1\u30f3\u3067\u524d\u51e6\u7406\u3057\u305fSARS-CoV-2\u306e\u7591\u4f3c\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u3066\u30ec\u30af\u30c1\u30f3\u306e\u4e2d\u548c\u6d3b\u6027\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002WGA\u3001lentil lectin\u3001PHA-L\u3001PHA-E \u3089\u304cSARS-CoV-2\u7591\u4f3c\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u975e\u5e38\u306b\u512a\u308c\u305f\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3057\u3001\u305d\u306eIC50<\/sub>\u306f 8.5 \u03bcg\/mL \u304b\u3089 22.0 \u03bcg\/mL\u306e\u7bc4\u56f2\u3067\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u30ec\u30af\u30c1\u30f3\u306b\u3088\u308b\u8840\u7403\u51dd\u96c6\u3068\u7d30\u80de\u6bd2\u6027\u306f\u3001\u30ec\u30af\u30c1\u30f3\u306e\u5fdc\u7528\u306b\u304a\u3044\u3066\u306f\u5e38\u306b\u8ab2\u984c\u3068\u306a\u308a\u307e\u3059\u3002 PHA-L \u3068 PHA-E \u306f\u3001\u8840\u6db2\u51dd\u96c6\u3092 3.91 \u03bcg\/mL\u3067\u793a\u3057\u3001WGA \u306f7.81 \u03bcg\/mL\u3067\u3057\u305f\u3002\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u306f\u3001\u6700\u3082\u5f31\u3044\u8840\u7403\u51dd\u96c6\u3092\u793a\u3057\u3001\u305d\u306e\u5024\u306f\u9ad8\u6fc3\u5ea6\u306e 1 mg\/mL\u3067\u3042\u308a\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u7d30\u80de\u6bd2\u6027\u306fHuh7\u6216\u3044\u306f293T\u3092\u4f7f\u7528\u3057\u300137\u2103\u306724\u6642\u9593\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u3066\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u3059\u3079\u3066\u306e\u30ec\u30af\u30c1\u30f3\u306f\u3001500 \u03bcg\/mL\u306e\u6fc3\u5ea6\u3067\u3082\u7d30\u80de\u6bd2\u6027\u3092\u793a\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u3053\u308c\u3089\u306e\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u304cSARS-CoV-2\u963b\u5bb3\u306b\u306f\u6700\u3082\u9069\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u306e\u5834\u5408\u306b\u306f\u3001SARS-CoV-2 Spike\u306e\u500b\u3005\u306eN-\u578b\u6216\u3044\u306fO-\u578b\u7cd6\u9396\u3092\u9664\u53bb\u3057\u3066\u3082\u305d\u306e\u4e2d\u548c\u6d3b\u6027\u306b\u306f\u5f71\u97ff\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u304cSARS-CoV-2 Spike\u306e\u591a\u304f\u306e\u7cd6\u9396\u4fee\u98fe\u30b5\u30a4\u30c8\u306b\u7d50\u5408\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u306f\u3001oligomannose-\u578b\u7cd6\u9396 (Man-5 \uff5e Man-9)\u306b\u5f37\u304f\u7d50\u5408\u3057\u3001\u9084\u5143\u672b\u7aef\u304cGlcNAc\u306e\u8907\u5408\u578b\u3084\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u578b\u7cd6\u9396\u306b\u3082\u7d50\u5408\u3057\u307e\u3059\u3002<\/p>\n

RBD\u306e\u5468\u8fba\u306b\u306f\u3001N165\u3001N234\u3001N343 \u306b\u7cd6\u9396\u4fee\u98fe\u30b5\u30a4\u30c8\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u30b5\u30a4\u30c8\u306e\u7cd6\u9396\u306b\u306f\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u306f\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u7279\u306bN234\u306f\u3001\u5b8c\u5168\u306aoligomannose-\u578b\u306a\u306e\u3067\u3001\u52b9\u679c\u7684\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u8208\u5473\u6df1\u3044\u306e\u306f\u3001\u3053\u308c\u30893\u3064\u306e\u7cd6\u9396\u4fee\u98fe\u30b5\u30a4\u30c8\u306e\u3069\u308c\u304b\u4e00\u3064\u3092\u9664\u53bb\u3057\u3066\u3082\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u306e\u4e2d\u548c\u6d3b\u6027\u306b\u306f\u5f71\u97ff\u304c\u306a\u304f\u3001\u6b8b\u3063\u305f\u4e8c\u3064\u306e\u30b5\u30a4\u30c8\u3067\u5341\u5206\u306a\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u306e\u4e2d\u548c\u6d3b\u6027\u3092\u7dad\u6301\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u73fe\u5728\u307e\u3067\u306b\u3001\u591a\u69d8\u306aSARS-CoV-2\u5909\u7570\u682a\u304c\u51fa\u73fe\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u304c\u3001N165\u3001N234\u3001N343 \u306f 100% \u4fdd\u5b58\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u306e\u4f7f\u7528\u306f\u3001SARS-CoV-2\u5909\u7570\u682a\u306b\u5bfe\u3059\u308b\u4e2d\u548c\u6d3b\u6027\u306e\u8a31\u5bb9\u7bc4\u56f2\u306e\u5e83\u3055\u304b\u3089\u3001\u3068\u3066\u3082\u512a\u308c\u305f\u9078\u629e\u80a2\u306a\u306e\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

National Institutes for Food and Drug Control (NIFDC), Beijing, China, \u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30ec\u30f3\u30ba\u8c46\u30ec\u30af\u30c1\u30f3\u304c\u3001SARS-CoV-2\u306e\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u3082\u6709\u671b<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-5196","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5196"}],"version-history":[{"count":15,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5196\/revisions"}],"predecessor-version":[{"id":7741,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5196\/revisions\/7741"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}