{"id":5000,"date":"2021-07-21T15:30:20","date_gmt":"2021-07-21T06:30:20","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=5000"},"modified":"2021-07-21T22:28:04","modified_gmt":"2021-07-21T13:28:04","slug":"covid-19%e3%81%a7%e9%ab%98%e9%bd%a2%e8%80%85%e3%81%8c%e9%87%8d%e7%97%87%e5%8c%96%e3%81%99%e3%82%8b%e3%81%ae%e3%81%af%e3%80%81t-%e7%b4%b0%e8%83%9e%e6%b8%9b%e5%b0%91%e7%97%87%e3%81%8c%e5%a4%a7%e3%81%8d","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/covid-19%e3%81%a7%e9%ab%98%e9%bd%a2%e8%80%85%e3%81%8c%e9%87%8d%e7%97%87%e5%8c%96%e3%81%99%e3%82%8b%e3%81%ae%e3%81%af%e3%80%81t-%e7%b4%b0%e8%83%9e%e6%b8%9b%e5%b0%91%e7%97%87%e3%81%8c%e5%a4%a7%e3%81%8d\/","title":{"rendered":"COVID-19\u3067\u9ad8\u9f62\u8005\u304c\u91cd\u75c7\u5316\u3059\u308b\u306e\u306f\u3001T-\u7d30\u80de\u6e1b\u5c11\u75c7\u304c\u5927\u304d\u306a\u539f\u56e0\u3060\u304c\u3001\u305d\u308c\u306f\u77ed\u304f\u306a\u3063\u305f\u30c6\u30ed\u30e1\u30a2\u306b\u539f\u56e0\u304c\u3042\u308b"},"content":{"rendered":"<p>University of Washington, Seattle, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5e74\u9f62\u3068\u3068\u3082\u306b\u77ed\u304f\u306a\u308bT-\u7d30\u80de\u306e\u30c6\u30ed\u30e1\u30a2\u9577\u304c\u3001COVID-19\u306e\u91cd\u75c7\u5316\u306b\u5f71\u97ff\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8282112\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8282112\/<\/a><\/p>\n<p>\u4e00\u6642\u7684\u306a\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u75c7\u306f\u3001\u6025\u6027\u547c\u5438\u5668\u4e0d\u5168\u306e\u611f\u67d3\u75c7\u3067\u306f\u4e00\u822c\u7684\u306b\u898b\u3089\u308c\u307e\u3059\u3002\u6025\u6fc0\u3067\u9577\u5f15\u304fCOVID-19\u306e\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u75c7\u306f\u3001\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u72ec\u7279\u3067T-\u7d30\u80de\u6570\u306e\u5927\u5e45\u306a\u6e1b\u5c11\u3092\u898b\u305b\u307e\u3059\u3002\u3053\u306eT-\u7d30\u80de\u6e1b\u5c11\u75c7\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u305d\u306e\u5168\u4f53\u50cf\u304c\u826f\u304f\u5206\u304b\u3063\u3066\u5c45\u306a\u3044\u306e\u3067\u3059\u304c\u3001COVID-19\u3067\u306eT-\u7d30\u80de\u6570\u306e\u6e1b\u5c11\u306f\u3001T-\u7d30\u80de\u306e\u6025\u901f\u3067\u5927\u639b\u304b\u308a\u306a\u30af\u30ed\u30fc\u30f3\u6027\u5897\u6b96\u3092\u5fc5\u8981\u3068\u3057\u3001\u305d\u308c\u306f\u30c6\u30ed\u30e1\u30a2\u9577\uff08TL\uff09\u306b\u4f9d\u5b58\u3057\u305f\u4e8b\u67c4\u306a\u306e\u3067\u3059\u3002\u9aa8\u9ac4\u6027\u7d30\u80de\u306e\u30c6\u30ed\u30e1\u30a2\u9577\uff08HCTL\uff09\u306f\u3001\u5e74\u9f62\u3068\u3068\u3082\u306b\u77ed\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u70ba\u3001\u9ad8\u9f62\u8005\u306b\u3088\u3063\u3066\u306f\u3001COVID-19\u306e\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u75c7\u3092\u88dc\u3044\u3001\u4e14\u3064\u5fa9\u6d3b\u3055\u305b\u308b\u306b\u5fc5\u8981\u306aT-\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u6027\u5897\u6b96\u304c\u884c\u3048\u306a\u3044\u53ef\u80fd\u6027\u304c\u591a\u5206\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u6025\u6027\u306a\u611f\u67d3\u75c7\u304c\u306a\u3044\u5834\u5408\u306b\u306f\u3001T-\u7d30\u80de\u306e\u6297\u4f53\u306f\u3086\u3063\u304f\u308a\u3068\u3057\u3066\u304a\u308a\u3001\u30ca\u30a4\u30fc\u30d6T-\u7d30\u80de\u306e\u534a\u751f\u306f5\u5e74\u3001\u30e1\u30e2\u30ea\u30fcT-\u7d30\u80de\u306e\u534a\u751f\u306f5\u30ab\u6708\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001SARS-CoV-2\u306e\u611f\u67d3\u306b\u76f4\u9762\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u6e1b\u5c11\u3057\u305fTL\u4f9d\u5b58\u306eT-\u7d30\u80de\u30af\u30ed\u30fc\u30f3\u6027\u5897\u6b96\u80fd\u529b\u306f\u3001T-\u7d30\u80de\u306e\u6b7b\u4ea1\u3068\u5897\u6b96\u306e\u9593\u3067\u4f9b\u7d66\u4e0d\u8db3\u306b\u9665\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u66f4\u306b\u306f\u3001SARS-CoV-2\u3092\u6392\u9664\u3059\u308b\u70ba\u306b\u306f\u3088\u308a\u591a\u304f\u306e\u30ca\u30a4\u30fc\u30d6T-\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u6027\u5897\u6b96\u3068SARS-CoV-2\u3068\u3044\u3046\u6297\u539f\u306b\u5bfe\u3059\u308b\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u3084\u30e1\u30e2\u30ea\u30fc\u7d30\u80de\u3078\u306e\u5206\u5316\u3082\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u3001\u30ca\u30a4\u30fc\u30d6T-\u7d30\u80de\u306e\u77ed\u3044\u30ec\u30ed\u30e1\u30a2\u306f\u3001\u611f\u67d3\u306b\u3088\u3063\u3066\u751f\u3058\u308bT-\u7d30\u80de\u6e1b\u5c11\u75c7\u304c\u7121\u304f\u3066\u3082\u3001\u30a6\u30a4\u30eb\u30b9\u3068\u6226\u3046\u305f\u3081\u306e\u7372\u5f97\u514d\u75ab\u306e\u80fd\u529b\u3092\u5236\u9650\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n<p>T-\u7d30\u80de\u306e\u88dc\u5145\u3068T-\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u30b5\u30a4\u30ba\uff08CS\uff09\u306b\u3064\u3044\u3066\u3001\u8457\u8005\u3089\u306e\u30e2\u30c7\u30eb\u3067\u306f\u4e0b\u8a18\u306e\u3088\u3046\u306a\u4eee\u5b9a\u304c\u7f6e\u304b\u308c\u3066\u3044\u307e\u3059\uff1a<br \/>\n(i) T\u30fc\u7d30\u80de\u306eTL\u4f9d\u5b58\u306e\u8907\u88fd\u505c\u6b62\u306f\u3001\u201ctelomeric brink\u201d (TLB) \u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u30015 kbase\u3067\u8907\u88fd\u306f\u6b62\u307e\u308b\u3082\u306e\u3068\u3059\u308b\u3001(ii) 20\u6b73\u306b\u304a\u3051\u308b\u30ca\u30a4\u30fc\u30d6T-\u7d30\u80de\u306eTL\uff08TL<sub>20<\/sub>\uff09\u306f\u3001TLB\u306b\u9054\u3059\u308b\u307e\u3067\u3001\u6bce\u5e740.03kbase\u306e\u5272\u5408g\u3067\u77ed\u304f\u306a\u308b\u3082\u306e\u3068\u3059\u308b\u3001(iii) \u6307\u6570\u95a2\u6570\u7684\u306a\u8907\u88fd\u3067\u3001\u4e00\u500b\u306e\u30ca\u30a4\u30fc\u30d6T-\u7d30\u80de\u304c20\u56de\u306e\u8907\u88fd\u3067\uff08Nmax\uff09\u3067\u7d04100\u4e07\u500b\u306e\u6700\u5927\u30af\u30ed\u30fc\u30f3\u30b5\u30a4\u30ba\uff08CMS\uff09\u306b\u9054\u3059\u308b\u3068\u3059\u308b\u3001(iv) \u30af\u30ed\u30fc\u30f3\u6027\u5897\u6b96\u306b\u3088\u308b\u6700\u5927\u306eTL\u77ed\u9396\u5316\u91cf\u3092 \u0394<sub>max<\/sub>\u3068\u3059\u308b\u3001(v) \u5e74\u9f62\u3068\u3068\u3082\u306b\u6e1b\u5c11\u3059\u308bTL\u77ed\u9396\u5316\u306b\u3088\u3063\u3066\u3001\u201cage of onset\u201d (X<sub>O<\/sub>)\u3067\u3001\u201ctelomeric onset\u201d (TLO = 6.4 kb)\u306b\u9054\u3059\u308b\u3068\u3059\u308b\u3001(vi) \u307b\u3068\u3093\u3069\u306e\u30e1\u30e2\u30ea\u30fcT-\u7d30\u80de\u306f\u3001\u5b50\u4f9b\u304b\u3089\u9752\u5e74\u671f\u306e\u9593\u306b\u65b0\u3057\u3044\u6297\u539f\u306b\u5bfe\u3057\u3066\u51fa\u6765\u4e0a\u304c\u3063\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Telomere-length_COVID-19-severity.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4981\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Telomere-length_COVID-19-severity-300x143.png\" alt=\"\" width=\"300\" height=\"143\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Telomere-length_COVID-19-severity-300x143.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Telomere-length_COVID-19-severity-600x286.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Telomere-length_COVID-19-severity-768x366.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/07\/Telomere-length_COVID-19-severity.png 918w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\nTL<sub>20<\/sub> = TL at age 20 years,<br \/>\nTL<sub>B<\/sub> = Telomeric brink, stopping cell replication,<br \/>\nTL<sub>O<\/sub> = TL at onset of clone size limitation,<br \/>\nX<sub>O<\/sub> = Age in years when TLO is reached,<br \/>\nMCS = Maximal clone size (~106 T cells),<br \/>\n\u0394<sub>max<\/sub> = TL shortening required for achieving MCS (~1.4kb)<\/p>\n<p>\u7d50\u679c\u3068\u3057\u3066\u3001\u30ca\u30a4\u30fc\u30d6T-\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u6027\u5897\u6b96\u306b\u304a\u3051\u308b\u30c6\u30ed\u30e1\u30a2\u9577\u306f\u3001SARS-CoV2\u611f\u67d3\u306e\u75c7\u72b6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308d\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3001\u3068\u3044\u3046\u306e\u3082\u3001\u5e74\u9f62\u3068\u3068\u3082\u306b\u30c6\u30ed\u30e1\u30a2\u9577\u304c\u77ed\u304f\u306a\u308b\u3053\u3068\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u3068\u6226\u3046\u306b\u5fc5\u8981\u306a\u5341\u5206\u91cf\u306eT-\u7d30\u80de\u3092\u4f9b\u7d66\u3067\u304d\u306a\u304f\u306a\u308b\u304b\u3089\u306a\u306e\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Washington, Seattle, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5e74\u9f62\u3068\u3068\u3082\u306b\u77ed\u304f\u306a\u308bT-\u7d30\u80de\u306e\u30c6\u30ed\u30e1\u30a2\u9577\u304c\u3001COVID-19\u306e\u91cd\u75c7\u5316\u306b\u5f71\u97ff\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/ww<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/covid-19%e3%81%a7%e9%ab%98%e9%bd%a2%e8%80%85%e3%81%8c%e9%87%8d%e7%97%87%e5%8c%96%e3%81%99%e3%82%8b%e3%81%ae%e3%81%af%e3%80%81t-%e7%b4%b0%e8%83%9e%e6%b8%9b%e5%b0%91%e7%97%87%e3%81%8c%e5%a4%a7%e3%81%8d\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-5000","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=5000"}],"version-history":[{"count":9,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5000\/revisions"}],"predecessor-version":[{"id":5038,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/5000\/revisions\/5038"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=5000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=5000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=5000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}