{"id":4963,"date":"2021-07-21T09:48:21","date_gmt":"2021-07-21T00:48:21","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=4963"},"modified":"2021-07-21T22:48:59","modified_gmt":"2021-07-21T13:48:59","slug":"covid-19%e5%9b%9e%e5%be%a9%e6%9c%9f%e6%82%a3%e8%80%85%e3%81%8b%e3%82%89%e9%81%b8%e5%88%a5%e3%81%95%e3%82%8c%e3%81%9f%e6%9c%80%e3%82%82%e5%84%aa%e3%82%8c%e3%81%9fsars-cov-2%e3%81%ab%e5%af%be%e3%81%99","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/covid-19%e5%9b%9e%e5%be%a9%e6%9c%9f%e6%82%a3%e8%80%85%e3%81%8b%e3%82%89%e9%81%b8%e5%88%a5%e3%81%95%e3%82%8c%e3%81%9f%e6%9c%80%e3%82%82%e5%84%aa%e3%82%8c%e3%81%9fsars-cov-2%e3%81%ab%e5%af%be%e3%81%99\/","title":{"rendered":"COVID-19\u56de\u5fa9\u671f\u60a3\u8005\u304b\u3089\u9078\u5225\u3055\u308c\u305f\u6700\u3082\u512a\u308c\u305fSARS-CoV-2\u306b\u5bfe\u3059\u308b\u4e2d\u548c\u6297\u4f53\u3068\u306f"},"content":{"rendered":"

Technische Universit\u00e4t Braunschweig, Institut f\u00fcr Biochemie, Biotechnologie und Bioinformatik, Abteilung Biotechnologie, Germany\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u56de\u5fa9\u671f\u60a3\u8005\u306e\u672b\u68a2\u8840\u5358\u6838\u7d30\u80de\uff08PBMC\uff09\u304b\u3089\u6297\u4f53\u30d5\u30a1\u30fc\u30b8\u30c7\u30a3\u30b9\u30d7\u30ec\u30a4\u6cd5\u3092\u7528\u3044\u3066\u3001SARS-CoV-2\u306b\u5bfe\u3059\u308b\u4e2d\u548c\u6297\u4f53\u3092\u958b\u767a\u3057\u305f\u7d50\u679c\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8260561\/<\/a><\/p>\n

\u6297\u4f53\u30d5\u30a1\u30fc\u30b8\u30c7\u30a3\u30b9\u30d7\u30ec\u30a4\u6cd5\u306f\u3001\u4eca\u65e5\u30bf\u30fc\u30b2\u30c3\u30c8\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u7528\u6297\u4f53\u306e\u958b\u767a\u306b\u304a\u3051\u308bin vitro\u306a\u6280\u8853\u3068\u3057\u3066\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8457\u8005\u3089\u306f\u3001\uff16\u4eba\u306eCOVID-19\u56de\u5fa9\u671f\u60a3\u8005\u304b\u3089\u5f97\u305f\u514d\u75ab\u30d5\u30a1\u30fc\u30b8\u30c7\u30a3\u30b9\u30d7\u30ec\u30a4\u3092\u4f7f\u7528\u3057\u3001SARS-CoV-2 RBD\u306b\u7d50\u5408\u3059\u308b\u6297\u4f53\u3092\u9078\u5225\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066SARS-CoV-2\u306b\u5bfe\u3059\u308b\u963b\u5bb3\u30fb\u4e2d\u548c\u6297\u4f53\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002<\/p>\n

30 \u7a2e\u985e\u306e\u6297\u4f53\u3092\u3001IgG\u3068\u3057\u3066\u306e\u7279\u6027\u8a55\u4fa1\u3092\u884c\u3046\u305f\u3081\u306b\u3001\u7d30\u80de\u5909\u6027\u52b9\u679c\uff08CPE\uff09\u30d9\u30fc\u30b9\u306e\u4e2d\u548c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30a2\u30c3\u30bb\u30a4\u3067\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u307e\u3057\u305f\u3002 \u3053\u306e\u30a2\u30c3\u30bb\u30a4\u306f\u3001250\u30d7\u30e9\u30fc\u30af\u5f62\u6210\u5358\u4f4d\uff08pfu\uff09\/\u30a6\u30a7\u30ebSARS-CoV-2\u304a\u3088\u30731\u03bcg\/ mL\uff08\u301c10 nM\uff09scFv-Fc\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002 CPE\u306f\u3001SARS-CoV-2\u611f\u67d3\u6642\u306b4\u65e5\u4ee5\u5185\u306b\u4f4d\u76f8\u5dee\u9855\u5fae\u93e1\u3067\u306f\u3063\u304d\u308a\u3068\u898b\u3048\u308b\u4e38\u307f\u3068\u5265\u96e2\u3092\u7279\u5fb4\u3068\u3057\u3001\u611f\u67d3\u3057\u3066\u3044\u306a\u3044\u7d30\u80de\u306f\u666e\u901a\u306e\u30b3\u30f3\u30d5\u30eb\u30a8\u30f3\u30b7\u30fc\u5358\u5c64\u3092\u7dad\u6301\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u6700\u9ad8\u306e\u4e2d\u548c\u6d3b\u6027\u3092\u793a\u3059 19 scFv-Fc \u3092\u518d\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3057\u300150mL\u306e\u57f9\u990a\u30b9\u30b1\u30fc\u30eb\u3067\u30d2\u30c8IgG\u3068\u3057\u3066\u751f\u6210\u3057\u307e\u3057\u305f\u3002RBD\u3001S1\u3001\u307e\u305f\u306fS1-S2\u3078\u306e\u7d50\u5408\u306e\u6700\u5927\u6709\u52b9\u6fc3\u5ea6\u306e\u534a\u5206 EC50<\/sub> \u5024\u304c\u6c7a\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002 STE90-C11\u3001STE90-B2-D12\u3001STE94-F6\u3001STE94-H2\u3068\u540d\u4ed8\u3051\u3089\u308c\u305f\u6297\u4f53\u306f\u3001\u5168\u3066\u306e\u6297\u539f\u306b\u5bfe\u3057\u30660.2 \uff5e 0.5 nM \u306e\u7bc4\u56f2\u306e EC50<\/sub> \u3092\u793a\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u3001STE90-C11 \u6297\u4f53\u304c\u6700\u3082\u512a\u308c\u305f\u4e2d\u548c\u6297\u4f53\u3067\u3042\u308b\u3068\u3057\u3066\u9078\u5225\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001STE90-C11 \u306f\u3001\u4e0b\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\u73fe\u5b58\u3059\u308b\u307b\u3068\u3093\u3069\u306e\u5909\u7570\u306b\u5bfe\u3057\u3066\u8a31\u5bb9\u7bc4\u56f2\u306b\u5165\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u73fe\u5728\u307e\u3067\u306b\u51fa\u73fe\u3057\u305f B.1.429\/B.1.427\u3001B.1.526\u3001B1.258\u0394\u3001B.1.535\u3001B.1.617\u3001B.1.1.33\u3089\u306e\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u8a31\u5bb9\u7bc4\u56f2\u306b\u3042\u308b\u3053\u3068\u306f\u7279\u51fa\u3059\u3079\u304d\u3067\u3057\u3087\u3046\u3002<\/p>\n

\"\"<\/a><\/p>\n

STE90-C11\u306e\u4e2d\u548c\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\u305f\u3081\u306b\u3001STE90-C11Fab\u3068SARS-CoV-2RBD\u306e\u8907\u5408\u4f53\u3092\u8abf\u88fd\u3057\u3001\u7d50\u6676\u5316\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u5f97\u3089\u308c\u305f\u7d50\u6676\u304b\u3089\u53ce\u96c6\u3055\u308c\u305fX\u7dda\u56de\u6298\u753b\u50cf\u306f\u30012.0\u00c5\u306e\u5168\u4f53\u7684\u306a\u5206\u89e3\u80fd\u9650\u754c\u306b\u6e21\u308b\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002\u5206\u5b50\u7f6e\u63db\u306b\u3088\u3063\u3066\u69cb\u9020\u3092\u89e3\u3044\u305f\u5f8c\u3001\u30e2\u30c7\u30eb\u304c\u96fb\u5b50\u5bc6\u5ea6\u306b\u7d44\u307f\u8fbc\u307e\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u5408\u9818\u57df\u306e\u7d0460\uff05\u304cVH\u30bb\u30b0\u30e1\u30f3\u30c8\u7531\u6765\u3067\u3042\u308a\u3001\u540c\u6642\u306b\u6700\u592710\u500b\u306e\u6c34\u7d20\u7d50\u5408\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u6b8b\u308a\u306e40\uff05\u306f\u3001VL\u30bb\u30b0\u30e1\u30f3\u30c8\u7531\u6765\u3067\u3042\u308a\u3001\u66f4\u306b8\u500b\u306e\u6c34\u7d20\u7d50\u5408\u304c\u76f8\u4e92\u4f5c\u7528\u3092\u5b89\u5b9a\u5316\u3055\u305b\u3066\u3044\u307e\u3057\u305f\u3002 STE90-C11\uff1aSARS-CoV-2 RBD\u8907\u5408\u4f53\u306eRBD\u3068ACE2\uff1aSARS-CoV-2 RBD\u8907\u5408\u4f53\u306e\u91cd\u7573\u306f\u3001STE90-C11\u306e\u4e2d\u548c\u6d3b\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001ACE2\u7d50\u5408\u30b5\u30a4\u30c8\u3078\u306e\u7af6\u5408\u53cd\u5fdc\u3067\u3042\u308a\u3001SARS-CoV-2 RBD\u3068STE90-C11\u306e\u76f8\u4e92\u4f5c\u7528\u754c\u9762\u306f\u307b\u3068\u3093\u3069\u30aa\u30fc\u30d0\u30fc\u30e9\u30c3\u30d7\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Technische Universit\u00e4t Braunschweig, Institut f\u00fcr Biochemie, Biotechnologie und Bioinformatik, Abteilung Biote<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-4963","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=4963"}],"version-history":[{"count":12,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4963\/revisions"}],"predecessor-version":[{"id":5040,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/4963\/revisions\/5040"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=4963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=4963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=4963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}